Article
Immunology
Stamatia Papoutsopoulou, Liam Pollock, Catherine Walker, William Tench, Sakim Shakh Samad, Francois Bergey, Luca Lenzi, Raheleh Sheibani-Tezerji, Phillip Rosenstiel, Mohammad Tauqeer Alam, Vitor A. P. Martins Dos Santos, Werner Mueller, Barry J. Campbell
Summary: The study showed that IL-10 plays a crucial role in regulating the NF kappa B signaling pathway in intestinal epithelial cells, contributing to the maintenance of intestinal homeostasis, especially in an inflammatory environment. Deficiency of IL-10 affects NF kappa B activity and related gene transcription, thereby impacting intestinal homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Annett Eitner, Sylvia Mueller, Christian Koenig, Arne Wilharm, Rebecca Raab, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible
Summary: IL-1 beta induces NO release and mitochondrial dysfunction, and both can be prevented by inhibiting iNOS with L-NIL. Additionally, enhancing cAMP or inhibiting AMPK can reduce the effects of IL-1 beta, preventing NO release and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Tian Xu, Xueqian Wang, Chongyang Ma, Jing Ji, Wenxiu Xu, Qi Shao, Xuejing Liao, Ying Li, Fafeng Cheng, Qingguo Wang
Summary: Baicalin has potential therapeutic effects in preventing cerebral ischemia by reducing neurological injury and inhibiting inflammatory responses through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biology
Stamatia Papoutsopoulou, Liam Pollock, Jonathan M. Williams, Maya M. L. F. Abdul-Mahdi, Reyhaneh Dobbash, Carrie A. Duckworth, Barry J. Campbell
Summary: IL-10 plays a crucial role in protecting against intestinal inflammation by regulating the NF kappa B pathway. Deficiency of IL-10 leads to dysregulation of gene and protein expression related to inflammation in the small intestine, as well as disrupted levels of IgA in serum and intestinal mucosa.
Article
Biochemistry & Molecular Biology
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Ki Hyun Kim
Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Francesca Favaro, Fedra Luciano-Mateo, Joaquim Moreno-Caceres, Miguel Hernandez-Madrigal, Demi Both, Chiara Montironi, Franziska Puschel, Ernest Nadal, Eric Eldering, Cristina Munoz-Pinedo
Summary: In non-small cell lung carcinoma, TRAIL death receptors autonomously regulate the expression and release of IL-8, contributing to a pro-tumorigenic inflammatory signature associated with NSCLC development and prognosis.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Anna Stierschneider, Petra Gruenstaeudl, Katrin Colleselli, Josef Atzler, Christian T. Klein, Harald Hundsberger, Christoph Wiesner
Summary: The study engineered a new optogenetic cell line that can activate NF-kappa B and ERK1/2 signaling pathways upon blue light exposure, providing spatial and temporal control over cellular activity. Light exposure enhanced cell attachment, invadopodia formation, and cell migration in 3D cultures, but did not significantly impact proliferation or viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Dmitry Kopelyanskiy, Chantal Desponds, Florence Prevel, Matteo Rossi, Romain Migliorini, Tiia Snaka, Remzi Onur Eren, Stephanie Claudinot, Lon-Fye Lye, Manolis Pasparakis, Stephen M. Beverley, Nicolas Fasel
Summary: Inducible nitric oxide synthase (iNOS) is involved in the control of intracellular human pathogens. Leishmania protozoan parasites carrying Leishmania RNA virus 1 (LRV1) induce low levels of iNOS and nitric oxide (NO), which fail to control infection. The induction of iNOS requires strong activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) triggered by LRV1-induced type I interferon (IFN). LRV1-bearing Leishmania parasites limit iNOS production by suppressing NF-kappa B activation. LRV1-induced iNOS may contribute to parasite metastasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dahae Lee, Akida Alishir, Tae Su Jang, Ki Hyun Kim
Summary: The study revealed that benzyl salicylate found in Cornus walteri has potential anti-inflammatory activity by inhibiting the production of inflammatory mediators and affecting the phosphorylation of certain protein kinases and the expression of transcription factors.
Article
Gastroenterology & Hepatology
Zhao-Yang Wang, Yu Liu, Shi-Peng Li, Jian-Jun Li, Zhen Zhang, Xue-Chun Xiao, Yang Ou, Hang Wang, Jin-Zhen Cai, Shuang Yang
Summary: This study identified IL-1ra as a key regulator in hepatic ischemia-reperfusion injury (IRI), with its expression being regulated by HIF-1 alpha. Ischemic preconditioning was shown to protect the liver from IRI through the HIF-1 alpha-IL-1ra pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sen Liang, Zhaoyao Chen, Hui Li, Zhilan Cang, Kailin Yin, Minghua Wu, Shouzhen Luo
Summary: The study demonstrated that umbelliferone possesses neuroprotective effects against ischemia/reperfusion injury by inhibiting the inflammatory pathway, leading to reduced neurological deficits and brain damage in rats.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Immunology
Barbara Choromanska, Piotr Mysliwiec, Tomasz Kozlowski, Magdalena Luba, Piotr Wojskowicz, Jacek Dadan, Katarzyna Makarewicz, Anna Zalewska, Mateusz Maciejczyk, Hanna Myliwiec, Katarzyna Choronnanska
Summary: This study found elevated levels of nitrosative stress, inflammation, and hypoxia biomarkers in patients with adrenal tumors. Nitrosative stress was associated with inflammation and hypoxia in different types of adrenal masses.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Meng-Jin Lin, Ping Lin, Kuo-Ching Wen, Hsiu-Mei Chiang, Mei-Chun Lu
Summary: This study evaluated the antioxidant and anti-inflammatory activities of Ficus awkeotsang Makino extract (FAE) on fibroblasts and mouse models. The results showed that FAE exhibited strong antioxidant and anti-inflammatory effects, and could inhibit UVB-induced inflammation. These findings highlight the potential of FAE as a versatile adjuvant against free radical damage in pharmaceutical applications.
Article
Pharmacology & Pharmacy
Jianwei Fan, Lifang Duan, Nan Wu, Xiaofan Xu, Jiaqi Xin, Shengnan Jiang, Cheng Zhang, Hong Zhang
Summary: Baicalin has been shown to inhibit the activation of pancreatic stellate cells (PSCs), reduce pancreatic inflammation and fibrosis, and decrease the levels of various markers associated with fibrosis in the pancreas. It inhibits the TGF-beta 1/TGF-beta R1/TAK1/NF-kappa B signaling pathway, leading to decreased MCP-1 secretion and reduced infiltration of macrophages and inflammation cells in the pancreas. This study provides a basis for the potential use of baicalin in the prevention and treatment of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stamatia Papoutsopoulou, Lorna Morris, Andrew Bayliff, Thomas Mair, Hazel England, Massimiliano Stagi, Francois Bergey, Mohammad Tauqeer Alam, Raheleh Sheibani-Tezerji, Philip Rosenstiel, Werner Muller, Vitor A. P. Martins Dos Santos, Barry J. Campbell
Summary: The NF kappa B transcription factors play a crucial role in innate immune responses and their dysregulation is associated with inflammatory diseases. In this study, the introduction of human RelA protein into mouse cells was shown to impact murine gene transcription, affecting both NF kappa B and non-NF kappa B target genes, and interfering with interferon and cytokine signaling pathways.