期刊
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
卷 23, 期 4, 页码 925-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2009.06.014
关键词
Bacterial meningitis; Cerebrospinal fluid; Antimicrobial therapy; Blood-brain barrier; Antimicrobial resistance
The principles of antimicrobial therapy for acute bacterial meningitis include use of agents that penetrate well into cerebrospinal fluid and attain appropriate cerebrospinal fluid concentrations, are active in purulent cerebrospinal fluid, and are bactericidal against the infecting pathogen. Recommendations for treatment of bacterial meningitis have undergone significant evolution in recent years, given the emergence of pneumococcal strains that are resistant to penicillin. Clinical experience with use of newer agents is limited to case reports, but these agents may be necessary to consider in patients who are failing standard therapy.
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