期刊
INFECTION GENETICS AND EVOLUTION
卷 28, 期 -, 页码 691-703出版社
ELSEVIER
DOI: 10.1016/j.meegid.2014.07.028
关键词
Sand flies; Salivary protein; Immunity; Leishmaniasis; Vaccine; Transcriptomes
资金
- Intramural Research Program of the NIH
- National Institute of Allergy and Infectious Diseases, United States
Sand flies are blood-feeding insects and vectors of the Leishmania parasite. For many years, saliva of these insects has represented a gold mine for the discovery of molecules with anti- hemostatic and immunomodulatory activities. Furthermore, proteins in sand fly saliva have been shown to be a potential vaccine against leishmaniasis and also markers of vector exposure. A bottleneck to progress in these areas of research has been the identification of molecules responsible for the observed activities and properties of saliva. Over the past decade, rapid advances in transcriptomics and proteomics resulted in the completion of a number of sialomes (salivary gland transcriptomes) and the expression of several recombinant salivary proteins from different species of sand fly vectors. This review will provide readers with a comprehensive update of recent advances in the characterization of these salivary molecules and their biological activities and offer insights pertaining to their protective effect against leishmaniasis and their potential as markers of vector exposure. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
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