期刊
INFECTION GENETICS AND EVOLUTION
卷 12, 期 2, 页码 181-190出版社
ELSEVIER
DOI: 10.1016/j.meegid.2011.11.014
关键词
West Nile virus; Molecular epidemiology; Population genetics; Pathogenesis; Fitness
West Nile virus (WNV) (Flaviviridae: Flavivirus) is transmitted from mosquitoes to birds, but can cause fatal encephalitis in infected humans. Since its introduction into North America in New York in 1999, it has spread throughout the western hemisphere. Multiple outbreaks have also occurred in Europe over the last 20 years. This review highlights recent efforts to understand how host pressures impact viral population genetics, genotypic and phenotypic changes which have occurred in the WNV genome as it adapts to this novel environment, and molecular epidemiology of WNV worldwide. Future research directions are also discussed. (C) 2011 Elsevier B.V. All rights reserved.
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