Article
Virology
Antti Vaheri, Teemu Smura, Hanna Vauhkonen, Jussi Hepojoki, Tarja Sironen, Tomas Strandin, Johanna Tietavainen, Tuula Outinen, Satu Maekelae, Ilkka Poersti, Jukka Mustonen
Summary: The clinical outcome of Puumala hantavirus (PUUV) infection varies widely, with some cases being asymptomatic and others leading to severe hemorrhagic fever with renal syndrome (HFRS) and even death. The severity of the infection may be influenced by genetic factors such as human leukocyte antigen (HLA) alleles and genes related to tumor necrosis factor (TNF) and complement system. Autoimmune phenomena, Epstein-Barr virus infection, and individual differences in ocular and central nervous system manifestations are also associated with PUUV infection.
Article
Infectious Diseases
Guillaume Castel, Hussein Alburkat, Caroline Tatard, Lara Dutra, Mathilde Criado, Marie Bouilloud, Tarja Sironen, Julien Pradel, Nathalie Charbonnel
Summary: This study investigated the circulation of PUUV in its animal reservoir during a large outbreak of NE in the southern Jura Mountains in France. The results showed a higher abundance of bank voles in 2021 compared to previous years and a high seroprevalence of PUUV in the captured animals during the human NE epidemic. Genetic analysis revealed clustering of PUUV strains without significant genetic variation.
INFECTIOUS DISEASES NOW
(2023)
Article
Infectious Diseases
Messaline Bermejo, Stephanie Mestrallet, Amelie Servettaz, Laure-Anne Pannet, Delphine Lebrun, Yohan N'Guyen, Laurent Andreoletti, Jean-Marc Reynes, Maxime Hentzien, Firouze Bani-Sadr
Summary: The study found that about one quarter of patients with HFRS had eosinophilia, which was associated with severe thrombocytopenia, high C-reactive protein levels, white blood cell count, and neutrophil count, and inversely associated with nephrotoxic drug intake. Elevated C-reactive protein concentrations were independently associated with eosinophilia, supporting the role of eosinophils in antiviral immunity against hantavirus infection.
INFECTIOUS DISEASES
(2022)
Article
Microbiology
Jean-Marc Reynes, Laura Schaeffer, Pavlos Papadopoulos, Mohand Ait-Ahmed, Dieyenaba Siby-Diakite, Maryline Ripaux-Lefevre, Tan-Phuc Buivan, Sylvie Lechat, Muriel Vray, Jean-Marc Galempoix, HANTADIAG Study Group
Summary: This study investigated the feasibility of using urine instead of plasma to detect PUUV RNA in patients with different PUUV subtypes in France. The results showed a lower detection rate of PUUV RNA in urine samples compared to plasma samples. Therefore, urine is not suitable as a sample for this type of detection.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Review
Virology
Antti Vaheri, Heikki Henttonen, Jukka Mustonen
Summary: Finland has the highest incidence of hantavirus infections globally, largely due to the large coverage of boreal forests and cyclic dynamics of the dominant forest rodent species, the bank vole Myodes glareolus. Human infection with hantavirus has unique pathobiological features but rarely has long-term consequences.
Article
Multidisciplinary Sciences
Mahdi Aminikhah, Jukka T. Forsman, Esa Koskela, Tapio Mappes, Jussi Sane, Jukka Ollgren, Sami M. Kivela, Eva R. Kallio
Summary: This study in Finland found that rodent population dynamics were associated with approximately 3-year cycles of human LB and PUUV infections incidence, with complex time lags in the relationship between LB and rodent abundance fluctuations.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Environmental
Saana Sipari, Hussein Khalil, Magnus Magnusson, Magnus Evander, Birger Hornfeldt, Frauke Ecke
Summary: This study uses long-term monitoring data from Northern Europe to show that climate change has an impact on the transmission of a zoonotic pathogen, increasing the risk of zoonotic diseases in the North.
Review
Medicine, General & Internal
Jukka Mustonen, Heikki Henttonen, Antti Vaheri, Lothar Zoeller, Detlev H. Krueger
Summary: Eight decades ago, a report on a swamp fever-like disease in German troops in Lapland was published in this journal. The report provided a precise analysis of the clinical presentation and it was the first description of hantavirus disease in the German language area. Nowadays, hantavirus disease, also known as Nephropathia epidemica in Central and Northern Europe, is one of the most frequently reported viral diseases in Germany and Finland.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Review
Urology & Nephrology
Felix C. Koehler, Veronica Di Cristanziano, Martin R. Spath, K. Johanna R. Hoyer-Allo, Manuel Wanken, Roman-Ulrich Muller, Volker Burst
Summary: Hantavirus-induced diseases, such as hemorrhagic fever and cardiopulmonary syndrome, have been frequently reported in different parts of the world. They primarily affect the endothelial cell barrier and immune response, with disease severity associated with genetic vulnerability. Currently, there are no specific treatments, and preventive measures and public awareness are crucial in reducing the risk of infection.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Felix C. Koehler, Linda Blomberg, Thomas Theo Brehm, Stefan Buettner, Oliver A. Cornely, Olaf Degen, Veronica Di Cristanziano, Sebastian Dolff, Lukas Eberwein, Elion Hoxha, K. Johanna R. Hoyer-Allo, Sarah Rudolf, Martin R. Spaeth, Manuel Wanken, Roman-Ulrich Mueller, Volker Burst
Summary: HantaReg is a novel registry platform designed to facilitate multinational research on hantavirus-caused diseases, providing standardized data entry and management. With a modular structure, the platform automatically displays relevant questions and items based on the specific case, offering researchers a convenient tool for information collection.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Infectious Diseases
Pablo A. Vial, Marcela Ferres, Cecilia Vial, Jonas Klingstrom, Clas Ahlm, Rene Lopez, Nicole Le Corre, Gregory Mertz
Summary: Hantavirus infections are viral haemorrhagic fevers that can be transmitted from infected rodents to humans, and in the case of Andes hantavirus, from person to person. Factors such as climate, environment, and human behavior play a role in their epidemiology and transmission. Hantaviruses target endothelial cells and can affect multiple organ systems, with increased vascular permeability being a key factor in their pathogenesis. The main clinical syndromes associated with hantaviruses are haemorrhagic fever with renal syndrome (HFRS) in Europe and Asia, and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Early clinical suspicion, rapid diagnostic testing, and access to critical care units are crucial for improving clinical outcomes in HCPS cases.
LANCET INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Christina Princk, Stephan Drewes, Kristin M. Meyer-Schlinkmann, Marion Saathoff, Florian Binder, Jona Freise, Beate Tenner, Sabrina Weiss, Jorg Hofmann, Jutta Esser, Martin Runge, Jens Jacob, Rainer G. Ulrich, Johannes Dreesman
Summary: In a small company in Germany, five employees contracted hantavirus infections in late 2017. Through investigations and serological testing, it was found that these infections were closely related to the bank vole population near the company. This investigation highlights the importance of a One Health approach in revealing the origin of hantavirus disease clusters.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Microbiology
Yuriy N. Davidyuk, Emmanuel Kabwe, Anton F. Shamsutdinov, Anna V. Knyazeva, Ekaterina V. Martynova, Ruzilya K. Ismagilova, Vladimir A. Trifonov, Tatiana A. Savitskaya, Guzel S. Isaeva, Richard A. Urbanowicz, Svetlana F. Khaiboullina, Albert A. Rizvanov, Sergey P. Morzunov
Summary: The study found that in the Trans-Kama area of the Republic of Tatarstan, PUUV strains mainly belonged to the RUS genetic lineage and clustered in two subclades in the Western and Eastern parts of the region within the Volga Federal District. It is suggested that the PUUV strains may have spread from the Western area to the Eastern area through the migration of bank voles.
Article
Virology
Danny Noack, Maja Travar, Visnja Mrdjen, Jolanda J. C. Voermans, David van de Vijver, Richard Molenkamp, Marion P. G. Koopmans, Marco Goeijenbier, Barry Rockx
Summary: This study investigated the associations between various immunological, hemostatic, and kidney injury markers and the severity of Puumala orthohantavirus (PUUV) infection. The results showed that IL-18 was increased and RANTES was decreased in patients with severe thrombocytopenia. Additionally, recently identified AKI biomarkers were upregulated in patients with severe PUUV infection, indicating pathology in glomeruli and proximal tubuli. E-selectin was higher and IP-10 was lower in patients with more severe kidney dysfunction. These findings suggest the involvement of immune responses, endothelial cell activation, and specific cytokines in the pathogenesis of PUUV-induced renal injury.
Article
Virology
Elfi K. Schlohsarczyk, Stephan Drewes, Pawel Koteja, Susanne Roehrs, Rainer G. Ulrich, Jens P. Teifke, Christiane Herden
Summary: This study investigated the tropism, pathological changes, and endoparasite coinfections in PUUV-infected bank voles. The results showed that PUUV caused persistent infection in bank voles and had a broad organ tropism, particularly affecting the kidney and stomach. Additionally, PUUV-infected voles were frequently coinfected with Hepatozoon spp. and Sarcocystis (Frenkelia) spp. The findings provide important insights into virus-host interactions in natural hantavirus reservoirs.
Article
Biochemistry & Molecular Biology
R. Leblois, M. Gautier, A. Rohfritsch, J. Foucaud, C. Burban, M. Galan, A. Loiseau, L. Saune, M. Branco, K. Gharbi, R. Vitalis, C. Kerdelhue
Article
Parasitology
A. Dubois, G. Castel, S. Murri, C. Pulido, J. -B. Pons, L. Benoit, A. Loiseau, L. Lakhdar, M. Galan, P. Marianneau, N. Charbonnel
Article
Entomology
Amelie Desvars-Larrive, Abdessalem Hammed, Ahmed Hodroge, Philippe Berny, Etienne Benoit, Virginie Lattard, Jean-Francois Cosson
JOURNAL OF PEST SCIENCE
(2019)
Correction
Endocrinology & Metabolism
Celia Bidu, Quentin Escoula, Sandrine Bellenger, Ayme Spor, Maxime Galan, Audrey Geissler, Andre Bouchot, Dominique Dardevet, Beatrice Morio-Liondor, Patrice D. Cani, Laurent Lagrost, Michel Narce, Jerome Bellenger
Article
Ecology
Audrey Rohfritsch, Maxime Galan, Mathieu Gautier, Karim Gharbi, Gert Olsson, Bernhard Gschloessl, Caroline Zeimes, Sophie VanWambeke, Renaud Vitalis, Nathalie Charbonnel
ECOLOGY AND EVOLUTION
(2018)
Article
Ecology
Elodie Portanier, Mathieu Garel, Sebastien Devillard, Daniel Maillard, Jocelyn Poissant, Maxime Galan, Slimania Benabed, Marie-Therese Poirel, Jeanne Duhayer, Christian Itty, Gilles Bourgoin
Article
Microbiology
Jean-Claude Ogier, Sylvie Pages, Maxime Galan, Matthieu Barret, Sophie Gaudriault
Article
Ecology
Orianne Tournayre, Maxime Leuchtmann, Ondine Filippi-Codaccioni, Marine Trillat, Sylvain Piry, Dominique Pontier, Nathalie Charbonnel, Maxime Galan
ECOLOGY AND EVOLUTION
(2020)
Article
Entomology
Ahmadou Sow, Julien Haran, Laure Benoit, Maxime Galan, Thierry Brevault
Article
Microbiology
Sarah Madrieres, Caroline Tatard, Severine Murri, Johann Vulin, Maxime Galan, Sylvain Piry, Coralie Pulido, Anne Loiseau, Emmanuelle Artige, Laure Benoit, Nicolas Lemenager, Latifa Lakhdar, Nathalie Charbonnel, Philippe Marianneau, Guillaume Castel
Article
Microbiology
Johann Vulin, Severine Murri, Sarah Madrieres, Maxime Galan, Caroline Tatard, Sylvain Piry, Gabriele Vaccari, Claudia D'Agostino, Nathalie Charbonnel, Guillaume Castel, Philippe Marianneau
Summary: The study describes the isolation of two strains of PUUMALA orthohantavirus from two distinct French geographical areas: Ardennes (endemic area) and Loiret (non-endemic area). By selecting wild bank voles, cultivating the strains efficiently in Vero E6 cells, and propagating them in immunologically neutral bank voles, the impact of isolation methods on viral diversity was better assessed through high-throughput and Sanger sequencing results.
Article
Ecology
Erwan Quemere, Pauline Hessenauer, Maxime Galan, Marie Fernandez, Joel Merlet, Yannick Chaval, Nicolas Morellet, Helene Verheyden, Emmanuelle Gilot-Fromont, Nathalie Charbonnel
Summary: Toll-like receptors play a central role in host defence against pathogens, with recent studies showing high polymorphism in Tlr genes. Research on the relationship between Tlr genotypes and pathogen infections reveals the impact of pathogen-mediated selection on innate immunity genetic diversity. These findings emphasize the importance of looking beyond MHC genes in wildlife immunogenetic studies and considering multiple pathogen challenges for a better understanding of vertebrate defence evolution.
JOURNAL OF EVOLUTIONARY BIOLOGY
(2021)
Article
Infectious Diseases
Guillaume Castel, Hussein Alburkat, Caroline Tatard, Lara Dutra, Mathilde Criado, Marie Bouilloud, Tarja Sironen, Julien Pradel, Nathalie Charbonnel
Summary: This study investigated the circulation of PUUV in its animal reservoir during a large outbreak of NE in the southern Jura Mountains in France. The results showed a higher abundance of bank voles in 2021 compared to previous years and a high seroprevalence of PUUV in the captured animals during the human NE epidemic. Genetic analysis revealed clustering of PUUV strains without significant genetic variation.
INFECTIOUS DISEASES NOW
(2023)
Article
Multidisciplinary Sciences
Ahmadou Sow, Thierry Brevault, Laure Benoit, Marie-Pierre Chapuis, Maxime Galan, Armelle Coeur d'acier, Gerard Delvare, Mbacke Sembene, Julien Haran
SCIENTIFIC REPORTS
(2019)