Article
Multidisciplinary Sciences
Denise Ann E. Dayao, Justyna J. Jaskiewicz, Abhineet S. Sheoran, Giovanni Widmer, Saul Tzipori
Summary: The authors identified a highly antigenic fragment of the zoonotic parasite Cryptosporidium gp900, which effectively differentiates between zoonotic C. parvum and species/genotypes that infect preferentially humans. This fragment could potentially play a key role in host restriction of certain Cryptosporidium species.
Article
Multidisciplinary Sciences
Claude Pasquier, Alain Robichon
Summary: Recent research reveals the presence of abundant viral small interference and micro RNAs in mammals, indicating their contribution to host responses and viral replication. The study explores the theoretical possibility of RNAi triggered by SARS-CoV-2 degrading host transcripts, and computational analysis shows complementary pairing between viral RNA and human transcriptome.
Article
Microbiology
Chien-Fu Wu, Nanako Aoki, Naoki Takeshita, Toshiyuki Fukuhara, Hiroshi X. Chiura, Tsutomu Arie, Ioly Kotta-Loizou, Ryo Okada, Ken Komatsu, Hiromitsu Moriyama
Summary: AaV1, a mycovirus, has unique features with both 5' cap and 3' poly(A) structures on its genomic segments, as well as specific deletions of dsRNA2. Fungal isolates carrying virions with defective dsRNA2s showed impaired growth and abnormal pigmentation. This makes AaV1 the first dsRNA virus to be identified with these features.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunfeng Shi, Baiyang Yu, Shan Cheng, Weiming Hu, Fen Liu
Summary: Through whole-genome bisulfite sequencing and RNA-seq, the potential impact of autophagy in regulating DNA methylation in Arabidopsis and its role in coping with nitrogen deficiency were determined. Differential expression of genes associated with DNA demethylation was observed, suggesting a correlation between DNA demethylation and the ability of Arabidopsis to cope with nitrogen deficiency. Additionally, DNA methylation was found to impact the biosynthesis of salicylic acid, providing insights into how autophagy defects may lead to SA-activated senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Maria Ines Alvelos, Mirko Brueggemann, F. X. Reymond Sutandy, Jonas Juan-Mateu, Maikel Luis Colli, Anke Busch, Miguel Lopes, Annemieke Aartsma-Rus, Julian Koenig, Kathi Zarnack, Decio L. Eizirik, Angela Castela
Summary: SRSF6 plays a crucial role in splicing regulation in immortalized human pancreatic beta-cells by recognizing specific motifs and determining splicing fate through its positioning. The binding sites of SRSF6 on regulated exons in several diabetes susceptibility genes are identified, highlighting its significance in beta-cell function and survival.
LIFE SCIENCE ALLIANCE
(2021)
Article
Infectious Diseases
Manoj Murhekar, Pattabi Kamaraj, Muthusamy Santhosh Kumar, Siraj Ahmed Khan, Ramesh Reddy Allam, Pradip Barde, Bhagirathi Dwibedi, Suman Kanungo, Uday Mohan, Suman Sundar Mohanty, Subarna Roy, Vivek Sagar, Deepali Savargaonkar, Babasaheb Tandale, Roshan Kamal Topno, C. P. Girish Kumar, Ramasamy Sabarinathan, Sailaja Bitragunta, Gagandeep Singh Grover, P. V. M. Lakshmi, Chandra Mauli Mishra, Provash Sadhukhan, Prakash Kumar Sahoo, Shivendra Kumar Singh, Chander Prakash Yadav, Rajesh Kumar, Shanta Dutta, G. S. Toteja, Nivedita Gupta, Sanjay M. Mehendale
Summary: The study found a substantial proportion of non-immune or partially immune children aged 5-17 years to diphtheria in India. The proportion of non-immune to diphtheria was lowest in the southern region and highest in the northeastern region. Additionally, the proportion of non-immune in urban areas was slightly higher than in rural areas.
LANCET INFECTIOUS DISEASES
(2021)
Review
Virology
Yashpal Singh Malik, Shubhankar Sircar, Sudipta Bhat, Mohd Ikram Ansari, Tripti Pande, Prashant Kumar, Basavaraj Mathapati, Ganesh Balasubramanian, Rahul Kaushik, Senthilkumar Natesan, Sayeh Ezzikouri, Mohamed E. El Zowalaty, Kuldeep Dhama
Summary: The severity of Covid-19 has led to its declaration as a pandemic, with AI and machine learning innovations significantly complementing traditional epidemiological tools. AI model systems have the potential to improve disease spread recognition and outbreak predictions, offering enhanced accuracy in disease diagnosis and drug identification.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Review
Obstetrics & Gynecology
Balasubramanian Ganesh, Thangarasu Rajakumar, Subhendu Kumar Acharya, Harpreet Kaur
Summary: This study evaluates the prevalence of maternal complications and outcomes for women with SCA/SCD. SCD significantly impacts pregnancy and leads to increased occurrences of perinatal and maternal outcomes, highlighting the importance of sufficient care during pregnancy. More research is needed on the prevalence of SCA/SCD in pregnant women among ethnic tribal populations in India.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Gopalan Krishnan Sivaraman, Visnuvinayagam Sivam, Balasubramanian Ganesh, Ravikrishnan Elangovan, Ardhra Vijayan, Mukteswar Prasad Mothadaka
Summary: The study reported the draft genome sequence of a unique ST28/t021 CA-MRSA strain isolated from ribbon fish, which is the first report from India. In addition to antibiotic resistance, this strain also harbors various virulence genes.
Review
Biochemistry & Molecular Biology
Yashpal S. Malik, Prashant Kumar, Mohd Ikram Ansari, Maged G. Hemida, Mohamed E. El Zowalaty, Ahmed S. Abdel-Moneim, Balasubramanian Ganesh, Sina Salajegheh, Senthilkumar Natesan, Shubhankar Sircar, Muhammad Safdar, O. R. Vinodhkumar, Phelipe M. Duarte, Shailesh K. Patel, Jorn Klein, Parastoo Rahimi, Kuldeep Dhama
Summary: The spike glycoprotein of SARS-CoV-2 is a potential target for developing diagnostic techniques and vaccines, as well as a key player in the interaction with host cells to mediate virus-cell membrane fusion. Specific neutralizing monoclonal and polyclonal antibodies targeting the S-protein have shown promise in inhibiting SARS-CoV-2 infectivity, providing potential therapeutics for both prevention and treatment of COVID-19.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Microbiology
Sujit Kumar Behera, Thankappan Sabarinath, Prasanta Kumar K. Mishra, Yosef Deneke, Ashok Kumar, Shanmugam ChandraSekar, Kuppusamy Senthilkumar, MedRam Verma, Balasubramanian Ganesh, Amol Gurav, Abhishek Hota
Summary: This study evaluated the efficacy of bioinformatics tools in predicting the structure and epitopes of the rLigBCon1-5 antigen. Predicted structure and potential B-cell and T-cell epitopes were compared with wet lab experiments, showing reliability and potential immunogenicity of the antigen. Computational approaches were found to be reliable for the serodiagnosis of leptospirosis, with IgG Dot ELISA Dipstick test and LAT serving as suitable assays for detection of porcine leptospirosis in peripheral level animal health care systems.
Article
Mathematics, Interdisciplinary Applications
Yashpal Singh Malik, Vinodhkumar Obli Rajendran, M. A. Ikram, Tripti Pande, Karthikeyan Ravichandran, Nagaraj Jaganathasamy, Balasubramanian Ganesh, Aridoss Santhakumar, Sina Salajegheh Tazerji, Md. Tanvir Rahman, Muhammad Safdar, Zunjar B. Dubal, Kuldeep Dhama
Summary: This study analyzed the real-time reproductive number in South Asian Association for Regional Cooperation (SAARC) member countries during the COVID-19 epidemic, and explored the correlation between COVID-19 deaths and factors such as health expenditure, population density, and literacy rate. The findings showed a significant positive correlation between COVID-19 deaths and health expenditure, while other factors did not show significant correlations with the number of cases and deaths.
CHAOS SOLITONS & FRACTALS
(2021)
Review
Public, Environmental & Occupational Health
Rounik Talukdar, Diplina Barman, Vallabh Thakkar, Suman Kanungo
Summary: This study aimed to estimate the utilization of dental health care services among adults in India. The findings showed that the utilization rate was 23.96%, with the highest estimate in the South Zone (30.02%). Publication bias was detected, and heterogeneity was attributed to socioeconomic, literacy, and health system performance factors.
HEALTH PROMOTION PERSPECTIVES
(2022)
Review
Medicine, General & Internal
Suman Kanungo, Andrew S. Azman, Thandavarayan Ramamurthy, Jaqueline Deen, Shanta Dutta
Summary: Cholera is an acute watery diarrheal disease caused by toxigenic Vibrio cholerae bacteria. It has resulted in seven pandemics in the past two centuries. Recent advances in molecular epidemiology, immunology, and vaccine development have been made. The Global Task Force on Cholera Control aims to reduce cholera deaths by 90% and eliminate local transmission in at least 20 countries by 2030.
Article
Immunology
Suman Kanungo, Pranab Chatterjee, Jayanta Saha, Tania Pan, Nandini Datta Chakrabarty, Shanta Dutta
Summary: The study found high WASH coverage among residents of urban slums in Kolkata, with some issues such as unhealthy disposal of children's stools. While most households had access to piped water, some still spent a significant amount of time fetching water. Food hygiene practices were good, but frequent consumption of street food was reported.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Arun S. Karthikeyan, Manikandan Srinivasan, Suman Kanungo, Bireshwar Sinha, Ankita Shrivastava, Karthikeyan Ramanujam, Santhosh Kumar Ganesan, Sathyapriya Subramaniam, Kulandaipalayam Natarajan Sindhu, Swathi Krishna, Prasanna Samuel, Winsley Rose, Venkata Raghava Mohan, Balaji Veeraraghavan, Temsunaro Rongsen-Chandola, Shanta Dutta, Ashish Bavdekar, Jacob John, Gagandeep Kang
Summary: This study found a high rate of inappropriate antibiotic use for fever in children in India, highlighting the potential risk of antimicrobial resistance due to frequent and inappropriate use of antibiotics.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Letter
Rheumatology
Manikandan Natesan, Arunagirinathan Narasingam, Ganesh Balasubramanian
INDIAN JOURNAL OF RHEUMATOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Balasubramanian Ganesh, Thangarasu Rajakumar, Mathiyazhakan Malathi, Natesan Manikandan, Jaganathasamy Nagaraj, Aridoss Santhakumar, Arumugam Elangovan, Yashpal Singh Malik
Summary: SARS-CoV-2 is the causative agent of COVID-19, which originated in Wuhan, China, causing a global public health crisis. This review compares it with SARS and MERS, providing insights for future prevention, control, and treatment strategies.
CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Aridoss Santhakumar, Jaganathasamy Nagaraj, Joseph K. David, Mathiyazhakan Malathi, Balasubramanian Ganesh, Natesan Manikandan, V. M. Padmapriya, Kaliyaperumal Kanagasabai, Govindasamy Elavarsu, Muthusamy Ravi, Bathyalan Nagaraju, Jayaraman Prabakaran, Pradeep Kumar, Shobini Rajan, Arumugam Elangovan
Summary: HIV prevalence among pregnant women in Tamil Nadu has been declining since 2003, however, there are significant variations among regions and districts, requiring tailored interventions to address the specific needs of each area.
CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
(2021)
Article
Infectious Diseases
Muthusamy Santhosh Kumar, Pattabi Kamaraj, Siraj Ahmed Khan, Ramesh Reddy Allam, Pradip Barde, Bhagirathi Dwibedi, Suman Kanungo, Uday Mohan, Suman Sundar Mohanty, Subarna Roy, Vivek Sagar, Deepali Savargaonkar, Babasaheb Tandale, Roshan Kamal Topno, Chethrapilly P. Girish Kumar, Ramasamy Sabarinathan, Velusamy Saravana Kumar, Sailaja Bitragunta, Gagandeep Singh Grover, Pinnaka V. M. Lakshmi, Chandra Mauli Mishra, Provash Sadhukhan, Prakash Kumar Sahoo, Shivendra K. Singh, Chander Prakash Yadav, Elangovan Ramya Dinesh, Thiyagarajan Karunakaran, Chinnasamy Govindhasamy, Thomas Daniel Rajasekar, Annadurai Jeyakumar, Arunachalam Suresh, Duraisamy Augustine, Paparaju Ashok Kumar, Rajesh Kumar, Shanta Dutta, Gurudayal S. Toteja, Nivedita Gupta, Hannah E. Clapham, Sanjay M. Mehendale, Manoj Murhekar
Summary: The study found that chikungunya virus transmission was higher in the southern, western, and northern regions of India compared to the eastern and northeastern regions. However, a higher proportion of the population susceptible to CHIKV in the eastern and northeastern regions suggests a vulnerability to outbreaks in the future. The survey findings will be beneficial in identifying target age groups and locations for surveillance and future CHIKV vaccine trials.