Article
Microbiology
Jia Jie Woon, Azanna Ahmad Kamar, Cindy Shuan Ju Teh, Nuryana Idris, Rosliza Zhazali, Suzana Saaibon, Harvinderjit Kaur Basauhra Singh, Jasreena Kaur Gill Charanjeet Singh, Adeeba Kamarulzaman, Sasheela Ponnampalavanar
Summary: This study describes an epidemiological investigation into a carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in a neonatal intensive care unit (NICU) and the subsequent strengthening of infection control interventions. The investigation identified gaps in existing infection control measures and implementation of immediate actions successfully halted further CRAB transmission.
Review
Microbiology
Yuan Jiang, Yinhuan Ding, Yueshuai Wei, Chunxia Jian, Jinbo Liu, Zhangrui Zeng
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a leading cause of healthcare-associated infections globally, particularly in intensive care units (ICUs). Cross-transmission between patients and the hospital environment may play a crucial role in ICU-acquired CRAB colonization and infection. The control and treatment of CRAB infection in ICUs are challenging due to its multiple-drug resistance. Therefore, it is important to systematically study the colonization, infection, transmission, and resistance mechanisms of CRAB in ICUs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Paula Eckardt, Kelsi Canavan, Rachel Guran, Elizabeth George, Nancimae Miller, Dianeysis H. Avendano, Myeongji Kim, Khaled Himed, Karen Heidi Gonzalez Ramirez
Summary: This study reports on an outbreak investigation and containment strategy for a carbapenem-resistant Acinetobacter baumannii outbreak in a community hospital's COVID intensive care unit. The study emphasizes the importance of prevention strategies and maintaining infection control best practices to reduce the spread of multidrug resistant organisms.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Health Care Sciences & Services
Emma L. Doughty, Haiyang Liu, Robert A. Moran, Xiaoting Hua, Xiaoliang Ba, Feng Guo, Xiangping Chen, Linghong Zhang, Mark Holmes, Willem van Schaik, Alan Mcnally, Yunsong Yu
Summary: This study conducted a three-month observational study in a 28-bed intensive care unit (ICU) in Hangzhou, China, to explore the persistence and evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii (CRAB). The study found that the ICU population of CRAB was dominated by OXA-23-producing global clone 2 isolates, which could be divided into 20 distinct clusters through genome sequencing. The study emphasized the importance of environmental CRAB reservoirs in the epidemiology of ICUs and the unique challenges in containing the spread of CRAB.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Microbiology
Clemence Risser, Julien Pottecher, Anne Launoy, Axel Ursenbach, Laure Belotti, Pierre Boyer, Rosalie Willemain, Thierry Lavigne, Stephanie Deboscker
Summary: This study describes bundle measures implemented to overcome a protracted carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in an 18-bed trauma ICU at Strasbourg University Hospital. By simultaneously implementing aggressive and complementary measures, such as strict patients and healthcare workers (HCWs) cohorting, the long-lasting CRAB epidemic was successfully curbed.
Article
Infectious Diseases
Hyeri Seok, Ji Hoon Jeon, Ji Hye Jung, Sang Hee Ahn, Minji Seo, Hyun Kyung Cho, Sul A. Sung, Su-Hyun Kim, Hee Kyoung Choi, Won Suk Choi, Dae Won Park
Summary: Increasing the frequency of environmental cleaning did not reduce the acquisition of CRAB in ICU, with ventilator utilization ratio potentially playing a more significant role than environmental cleaning. Inexperienced nurses may contribute to the increased incidence of CRAB acquisition.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
J. Jung, P. G. Choe, S. Choi, E. Kim, H. Y. Lee, C. K. Kang, J. Lee, W. B. Park, S. Lee, N. J. Kim, E. H. Choi, M. Oh
Summary: Renovating intensive care units into single rooms is an effective strategy to prevent transmission of multi-drug resistant organisms and hospital-acquired infections.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Infectious Diseases
Suhaila A. Al-Sheboul, Salam Z. Al-Moghrabi, Yasemin Shboul, Farah Atawneh, Ahmed H. Sharie, Laila F. Nimri
Summary: This study aimed to determine the presence and distribution of bla(OXA) genes among multidrug-resistant A. baumannii isolated from ICU patients in Jordanian hospitals. The results showed a high prevalence of multidrug-resistant strains with ESBL phenotype. Identification of ESBL genes is crucial for monitoring their transmission in hospitals.
Article
Infectious Diseases
Hangbin Hu, Yifeng Lou, Haiting Feng, Jingjing Tao, Weixiao Shi, Shuangling Ni, Qunying Pan, Tianxiang Ge, Ping Shen, Zifeng Zhong, Yonghong Xiao, Tingting Qu
Summary: This study aimed to investigate the relationship between nosocomial infections and environmental health in ICU, specifically focusing on the transmission of carbapenem-resistant Acinetobacter baumannii (CRAB) between patients and their surroundings. The study found that CRAB isolates spread from patients to the ICU environment. However, effective infection control measures such as contact isolation and disinfection protocols can prevent transmission.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Tanya V. Strateva, Ivo Sirakov, Temenuga J. Stoeva, Alexander Stratev, Slavil Peykov
Summary: This study investigates the phenotypic and molecular characteristics of antimicrobial resistance in carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from ICU patients in Bulgaria. The results show the high levels of multidrug resistance and clonal spread of CRAB, highlighting the need for nationwide surveillance during COVID-19.
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Article
Immunology
Steven M. Smoke, Alison Brophy, Samuel Reveron, Alina Iovleva, Ellen G. Kline, Michael Marano, Lincoln P. Miller, Ryan K. Shields
Summary: This study reports on the treatment outcomes of 11 critically ill burn patients using cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. The clinical success rate was 36%, but was complicated by the emergence of treatment-resistant A. baumannii and its transmission among patients. The resistant strains harbored disrupted pirA and piuA genes, which were not disrupted in susceptible strains.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Frida Rivera, Allison Reeme, Mary Beth Graham, Blake W. Buchan, Nathan A. Ledeboer, Ann M. Valley, L. Silvia Munoz-Price
Summary: This study assessed the epidemiology of CRAB infection in postacute care facilities and found that residents in these facilities were more susceptible to CRAB colonization. Stool samples were most effective in identifying CRAB.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Infectious Diseases
Samy Selim, Osama Ahmed Faried, Mohamed S. Almuhayawi, Osama A. Mohammed, Fayez M. Saleh, Mona Warrad
Summary: Acinetobacter baumannii is a nonfermenting Gram-negative bacterium associated with nosocomial infections. This study identified four distinct lineages of A. baumannii and found that genotype (A) isolates showed reduced effectiveness to certain antibiotics. Additionally, the binding affinity of imipenem towards Acinetobacter baumannii OXA beta-lactamase enzymes was investigated.
Article
Medicine, General & Internal
Joung-Hee Byun, Su Eun Park, Minhae Seo, Jeungmi Jang, Mi Sun Hwang, Ju Yeoun Song, Chulhun L. Chang, Young A. Kim
Summary: The successful management and termination of an MDRAB outbreak in a pediatric intensive care unit was achieved by implementing a comprehensive infection-control strategy that focused on promoting hand hygiene, universal contact precautions, and environmental management through multidisciplinary teamwork.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Pediatrics
Leah Molloy, Eric McGrath, Ronald Thomas, Keith S. Kaye, Michael J. Rybak
CLINICAL PEDIATRICS
(2017)
Article
Nutrition & Dietetics
Winston Koo, Hilary Tice
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2018)
Article
Oncology
Pournima Navalkele, Bulent Ozgonenel, Eric McGrath, Paul Lephart, Sharada Sarnaik
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2017)
Article
Infectious Diseases
Jichang Chen, Jinjian Fu, Wei Du, Xin Liu, Chokechai Rongkavilit, Xuemei Huang, Yubi Wu, Yuanliu Wang, Eric McGrath
BMC INFECTIOUS DISEASES
(2018)
Article
Nutrition & Dietetics
Nansi S. Boghossian, Winston Koo, Aiyi Liu, Sunni L. Mumford, Michael Y. Tsai, Edwina H. Yeung
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Public, Environmental & Occupational Health
Jichang Chen, Xuemei Huang, Bo Wang, Yu Zhang, Chokechai Rongkavilit, Dingyuan Zeng, Yongjiang Jiang, Ba Wei, Chawla Sanjay, Eric McGrath
Article
Pediatrics
Yan Ling Ding, Jinjian Fu, Jichang Chen, Sheng Fu Mo, Shaolin Xu, Nan Lin, Peixu Qin, Eric McGrath
Letter
Public, Environmental & Occupational Health
Eric J. McGrath, Donia Dalal, Lynn Smitherman, Sharon Marshall, Christopher Youngman, Charles J. Barone, Herman Gray, Najibah Rehman, Elizabeth Secord
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Editorial Material
Pediatrics
Tessa Lewitt, Eric McGrath
CLINICAL PEDIATRICS
(2021)
Editorial Material
Pediatrics
Eric McGrath, Elizabeth Secord
CLINICAL PEDIATRICS
(2022)
Article
Pediatrics
Saiteja Mogasala, Elizabeth Secord, Eric Mcgrath
CLINICAL PEDIATRICS
(2023)
Article
Pediatrics
Jocelyn Y. Ang, Nirupama Kannikeswaran, Katherine Parker, Eric McGrath, Nahed Abdel-Haq, Harbir Arora, Jorge L. Lua, Ronald Thomas, Hossein Salimnia, Teena Chopra, Tommy Tran, Basim Asmar
Summary: The study on pediatric COVID-19 patients at Children's Hospital of Michigan revealed high hospitalization rates and intensive care requirements, especially among minority populations, indicating a health disparity that needs further investigation.
GLOBAL PEDIATRIC HEALTH
(2021)
Article
Pediatrics
Cory McFall, Hossein Salimnia, Paul Lephart, Ronald Thomas, Eric McGrath
CLINICAL PEDIATRICS
(2018)
Article
Pediatrics
Eric McGrath, Wei Du, Madhvi Rajpurkar
CLINICAL PEDIATRICS
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Winston Koo