Article
Immunology
Mariana Albano, Wim Alexander Fleischmann, Kerryl E. Greenwood-Quaintance, Robin Patel
Summary: Arbekacin showed inhibitory activity against drug-resistant Gram-negative bacilli, with similar MIC50 values to amikacin and gentamicin, lower than tobramycin, and higher than plazomicin.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Melise Chaves Silveira, Claudio Marcos Rocha-de-Souza, Ivson Cassiano de Oliveira Santos, Leilane da Silva Pontes, Thamirys Rachel Tavares e Oliveira, Camila Bastos Tavares-Teixeira, Nataly de Almeida Cossatis, Natacha Ferreira Pereira, Orlando Carlos da Conceicao-Neto, Bianca Santos da Costa, Daiana Cristina Silva Rodrigues, Rodolpho Mattos Albano, Fabricio Alves Barbosa da Silva, Elizabeth Andrade Marques, Robson Souza Leao, Ana Paula D'Alincourt Carvalho-Assef
Summary: The study of gram-negative bacilli isolated from bloodstream infections in Brazil using whole-genome sequencing revealed the presence of international high-risk clones and specific gene associations. Additionally, new clones and resistance gene relationships were observed, providing insights for developing approaches to tackle bloodstream infections and nosocomial infections caused by these important pathogens.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Faduma Nur Adan, Mohamed Osman Omar Jeele, Nasteho Mohamed Sheikh Omar
Summary: This study analyzes the epidemiology of MDR-NFGNB among HAP patients in a tertiary care hospital in Somalia. The prevalence rate of NFGNB in HAP patients was 8%, with higher rates in men and the elderly. Acinetobacter baumannii and Stenotrophomonas maltophilia exhibited the highest antibiotic resistance rate.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Ayan Ali Ragueh, Mohamed Houmed Aboubaker, Sitani Idriss Mohamed, Jean-Marc Rolain, Seydina M. Diene
Summary: This study investigated the resistance rate to carbapenems among multidrug-resistant Gram-negative bacteria (MDR-GNB) in Djibouti and characterized their resistance mechanisms. The results showed that out of 256 isolates, 20 were resistant to carbapenems. Carbapenemase genes such as bla(OXA-48) and bla(NDM-5) were identified in the isolates.
Article
Pediatrics
Marwyn Sowden, Evette Van Niekerk, Andre Nyandwe Hamama Bulabula, Angela Dramowski, Andrew Whitelaw, Jos Twisk, Mirjam Maria Van Weissenbruch
Summary: The study found that a multi-strain probiotic can effectively reduce the incidence of early and late rectal colonization with drug-resistant Gram-negative bacteria (DR-GNB) in preterm neonates, which is of great significance for improving the health outcomes of preterm infants.
FRONTIERS IN PEDIATRICS
(2022)
Article
Microbiology
Christine A. Pybus, Christina Felder-Scott, Victor Obuekwe, David E. Greenberg
Summary: The study compared the antimicrobial activity of Cefiderocol with seven commonly used antibiotics against multidrug-resistant pathogens, finding that Cefiderocol had potent inhibitory effects on biofilms of various pathogens, with consistently lower MIC90 values compared to other antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis
Summary: In endemic regions, mortality rates for multidrug-resistant bloodstream infections remain high, and high procalcitonin is the only predictor for death, while the use of rapid diagnostic tests did not improve mortality rates.
Article
Immunology
Marta Katkowska, Katarzyna Garbacz, Ewa Kwapisz, Klaudia Suligowska, Aida Kusiak, Dominika Cichonska, Dariusz Swietlik
Summary: This study found a high prevalence of multi-drug resistant Gram-negative bacilli colonization in the oral cavity of healthy adolescents, and the production of ESBLs was significantly associated with respiratory infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li
Summary: As multidrug-resistant pathogens emerge and spread rapidly, novel antibiotics are urgently needed. Traditional Chinese medicine, such as baicalein, can be used as an adjuvant to enhance the efficacy of antibiotics. Baicalein was found to potentiate doxycycline against multidrug-resistant Gram-negative pathogens by disrupting the bacterial membrane and enhancing antibiotic entry. It can also increase the production of reactive oxygen species and inhibit multidrug efflux pumps and biofilm formation to potentiate antibiotic efficacy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
M. Cristina Vazquez Guillamet, Christopher Damulira, Andrew Atkinson, Victoria J. Fraser, Scott Micek, Marin H. Kollef
Summary: The combination of aminoglycosides and β-lactams is more effective in reducing the incidence of infections caused by multidrug-resistant Gram-negative bacilli compared to β-lactams alone. This retrospective cohort study analyzed septic patients treated between 2010 and 2017, and found that the addition of aminoglycosides to β-lactams significantly decreased the risk of subsequent infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Priya Kannian, Pasuvaraj Mahanathi, Veeraraghavan Ashwini, Muthu Vaishnavi, Chandran Priya
Summary: Carbapenems were originally introduced against multidrug-resistant Gram-negative bacilli, but are now causing an increase in carbapenem-resistant strains due to initial empiric use. The carbapenem-resistant isolates show higher resistance to other antibiotics and majority are extended-spectrum beta-lactamase producers. Overall, carbapenem-resistant Gram-negative bacilli are predominantly multidrug-resistant or pan-drug resistant.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Public, Environmental & Occupational Health
Heba Alhmidi, Jennifer L. Cadnum, Sreelatha Koganti, Annette L. Jencson, Brigid M. Wilson, Curtis J. Donskey
Summary: Limited information is available on the frequency of and risk factors for shedding of health care-associated pathogens in settings outside patient rooms. The study found that environmental shedding of MRSA occurs frequently during appointments outside hospital rooms or during outpatient clinic visits, and the presence of a wound with a positive culture for MRSA was associated with shedding of MRSA during appointments.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Review
Microbiology
Slavil Peykov, Tanya Strateva
Summary: Non-fermenting Gram-negative bacilli (NFGNB), such as Pseudomonas aeruginosa and Acinetobacter baumannii, are major opportunistic pathogens involved in the global antibiotic resistance epidemic. The prevalence of multidrug-resistant NFGNBs in the Balkans, particularly carbapenem-resistant Acinetobacter spp. and P. aeruginosa isolates, is a cause for concern. Additionally, Stenotrophomonas maltophilia is emerging as a healthcare-associated pathogen, causing severe infections in different patient populations. The current situation in the Balkans, including the migrant crisis and border reshaping, poses challenges for antimicrobial stewardship and infection control.
Review
Infectious Diseases
Zineb Cherak, Lotfi Loucif, Abdelhamid Moussi, Jean-Marc Rolain
Summary: Carbapenem resistance in Gram-negative bacteria is a major public health challenge, with transmission mainly occurring through water environments. Aquatic environments serve as a significant medium for antibiotic gene transfer, playing a crucial role in the spread of drug resistance in the environment and community.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
