☆ 4.4 Article

Two Time-Series Analyses of the Impact of Antibiotic Consumption and Alcohol-Based Hand Disinfection on the Incidences of Nosocomial Methicillin-Resistant Staphylococcus aureus Infection and Clostridium difficile Infection

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2009)

期刊

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

卷 30, 期 4, 页码 346-353

出版社

UNIV CHICAGO PRESS

DOI: 10.1086/596605

关键词

类别

Public, Environmental & Occupational Health Infectious Diseases

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

摘要

OBJECTIVE. To determine the impact of antibiotic consumption and alcohol-based hand disinfection on the incidences of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection and Clostridium difficile infection (CDI). METHODS. Two multivariate time-series analyses were performed that used as dependent variables the monthly incidences of nosocomial MRSA infection and CDI at the Freiburg University Medical Center during the period January 2003 through October 2007. The volume of alcohol-based hand rub solution used per month was quantified in liters per 1,000 patient-days. Antibiotic consumption was calculated in terms of the number of defined daily doses per 1,000 patient-days per month. RESULTS. The use of alcohol-based hand rub was found to have a significant impact on the incidence of nosocomial MRSA infection (P < .001). The multivariate analysis (R(2) = 0.66) showed that a higher volume of use of alcohol-based hand rub was associated with a lower incidence of nosocomial MRSA infection. Conversely, a higher level of consumption of selected antimicrobial agents was associated with a higher incidence of nosocomial MRSA infection. This analysis showed this relationship was the same for the use of second-generation cephalosporins (P = .023), third-generation cephalosporins (P = .05), fluoroquinolones (P = .01), and lincosamides (P = .05). The multivariate analysis (R(2) = 0.55) showed that a higher level of consumption of third-generation cephalosporins (P = .008), fluoroquinolones (P = .084), and/or macrolides (P = .007) was associated with a higher incidence of CDI. A correlation with use of alcohol-based hand rub was not detected. CONCLUSION. In 2 multivariate time-series analyses, we were able to show the impact of hand hygiene and antibiotic use on the incidence of nosocomial MRSA infection, but we found no association between hand hygiene and incidence of CDI.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.4

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

Clostridium difficile Infection Reservoirs Within an Acute Rehabilitation Environment

Justin Weppner, Joelle Gabet, Mark Linsenmeyer, Mohamed Yassin, Gary Galang

Summary: The study found the presence of C difficile spores in an acute rehabilitation environment and showed that proper disinfection methods can effectively reduce the risk of infection. It is important to sporicidally disinfect surfaces such as beds and wheelchairs to decrease the rates of C difficile infection.

AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION (2021)