Article
Oncology
Rosangela Aparecida Mendes Silva, Regina Maria Holanda de Mendonca, Simone dos Santos Aguiar, Julia Cervellini Yajima, Fernando Augusto Lima Marson, Silvia Regina Brandalise, Carlos Emilio Levy
Summary: BSI is a frequent event in ALL patients during the induction phase, and is significantly associated with variables such as protocol for Derived T Protocol, oral manifestations, central venous catheter, and bladder catheter. Identifying these factors can help in the development and improvement of strategies for supportive care, prevention, and rapid treatment of infections.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Pediatrics
Michelle Baczynski, Ashraf Kharrat, Faith Zhu, Xiang Y. Ye, Prakesh S. Shah, Dany E. Weisz, Amish Jain
Summary: This study found that within +/- 4 hours of bloodstream infection onset, low mean blood pressure and high base deficit were independently associated with mortality in preterm neonates. The AUC for base deficit was 0.87, increasing to 0.91 with the addition of mean blood pressure.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Yong Chan Kim, Heun Choi, Young Ah Kim, Yoon Soo Park, Young Hee Seo, Hyukmin Lee, Kyungwon Lee
Summary: Understanding the risk factors and microbiological features in recurrent E. coli BSI can aid clinicians in their management planning. Data from 2017 to 2018 were collected to assess antimicrobial resistance rates and molecular epidemiology. Risk factors for recurrence included vascular catheterization, ESBL phenotype, and high SOFA score. The highest proportion of ST131 and ESBL genotype was observed in early onset recurrent BSI. Whole genome sequencing revealed the presence of various virulence factors, resistant genes, and plasmid types in all types of BSI. This knowledge is important for clinicians in managing recurrent E. coli BSI.
Article
Biotechnology & Applied Microbiology
Zhenhua Qian, Shufang Zhang, Na Li, Weixing Ma, Kai Zhang, Feizhen Song, Cheng Zheng, Li Zhong, Yesong Wang, Jiachang Cai, Hongwei Zhou, Wei Cui, Gensheng Zhang
Summary: Polymicrobial Acinetobacter baumannii bloodstream infection is relatively rare, mostly originating from skin and soft tissue infections, with burn injury being an independent risk factor. Patients with polymicrobial infection had longer hospital stays and more days of hospitalization after infection compared to those with monomicrobial infection. However, there was no significant difference in mortality between the two groups.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Microbiology
Mladen Pospisil, Haris Car, Vesna Elvedi-Gasparovic, Natasa Beader, Zoran Herljevic, Branka Bedenic
Summary: This study aimed to assess the resistance determinants and therapy outcome of AmpC-producing Enterobacterales associated with bloodstream infections. The findings showed no difference in the prevalence of comorbidities and previous surgical procedures between resistant and susceptible isolates. No difference was reported in mortality rates. The study also revealed the distribution of antibiotic resistance patterns among different strains.
Article
Pharmacology & Pharmacy
Beatriz Dietl, Lucia Boix-Palop, Laura Gisbert, Aina Mateu, Gemma Garreta, Mariona Xercavins, Cristina Badia, Maria Lopez-Sanchez, Josefa Perez, Esther Calbo
Summary: This study aimed to identify risk factors associated with inappropriate empirical antimicrobial treatment (i-EAT) in the treatment of bloodstream infections (BSI) in adults. The study found that male gender, nosocomial and healthcare-associated acquisition of infection, a high Charlson Comorbidity Index (CCI) score, and isolation of multidrug resistant (MDR) microorganisms were more frequent in the i-EAT group. Patients receiving i-EAT had higher mortality rates compared to patients with appropriate empirical antimicrobial treatment (a-EAT). The study suggests that some i-EAT related factors are unmodifiable, but others such as correct identification of clinical syndrome and adherence to local guidelines can optimize the use of antimicrobials.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Andrea Cona, Alessandro Tavelli, Andrea Renzelli, Benedetta Varisco, Francesca Bai, Daniele Tesoro, Alessandro Za, Caterina Biassoni, Lodovica Battaglioli, Marina Allegrini, Ottavia Vigano, Lidia Gazzola, Teresa Bini, Giulia Carla Marchetti, Antonella d'Arminio Monforte
Summary: A cohort study was conducted on hospitalized COVID-19 patients to assess bloodstream infections (BSIs). The study found a higher incidence of HA-BSI and longer hospital stay in HA-BSI patients, but a similar in-hospital mortality compared to non-BSI groups. Development of HA-BSI did not significantly affect mortality, while patients treated with corticosteroid therapy had double the risk of developing BSI.
Article
Infectious Diseases
Junhong Xu, Youhua Yuan, Baoya Wang, Qi Zhang, Jing Wang, Shanmei Wang, Yi Li, Wenjuan Yan
Summary: The purpose of this study was to investigate the etiological characteristics and risk factors affecting the prognosis of patients with polymicrobial bloodstream infections. A total of 141 patients were included, and various factors such as laboratory test indexes and medical history were collected for analysis. The results showed that patients with polymicrobial bloodstream infections were usually critically ill and the most common microbial strains detected were multidrug-resistant bacteria.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Virology
Nosheen Nasir, Fazal Rehman, Syed Furrukh Omair
Summary: This study found that adverse outcomes in COVID-19 patients are often due to bacterial coinfection, with risk factors including critical illness at presentation and use of steroids. There is also a widespread use of empiric antibiotics in patients without bacterial infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Microbiology
Li Zhong, Zhaohui Dong, Fengqi Liu, Haidong Li, Kankai Tang, Cheng Zheng, Lifang Wang, Kai Zhang, Jiachang Cai, Hongwei Zhou, Wei Cui, Yanqiu Gao, Gensheng Zhang
Summary: The incidence of mixed Candida/bacterial bloodstream infections (mixed C/B-BSIs) is high in adult patients in China. Compared with monomicrobial candidemia, patients with mixed C/B-BSIs are more likely to develop septic shock, have prolonged ICU stay, longer mechanical ventilation time, and higher mortality.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Obstetrics & Gynecology
Anshu A. A. Paul, Eliza Gentzler, Kyra Solowey, Surya Manickam, Irene Frantzis, Luis Alba, Maria Messina, Sandhya S. S. Brachio, Lisa Saiman
Summary: This study investigated the epidemiology of primary bloodstream infections (BSIs), secondary BSIs, and central line-associated BSIs (CLABSIs) in neonatal intensive care unit patients, as well as the applicability of CDC definitions for infection sources causing secondary BSIs. The results showed a decline in the incidence of primary BSIs, secondary BSIs, and CLABSIs during the study period. Gestational age <28 weeks was associated with increased incidence of all types of healthcare-associated BSIs. CDC criteria for site-specific primary sources were met in a majority of secondary BSIs.
JOURNAL OF PERINATOLOGY
(2023)
Article
Engineering, Biomedical
Hadrien Winiszewski, Charles Boyadjian, Guillaume Besch, Thibaud Soumagne, Martin Jeanney, Sebastien Pili-Floury, Damien Fournier, Francois Belon, Sidney Chocron, Gilles Capellier, Andrea Perrotti, Gael Piton
Summary: Cannula-related infections (CRI) are a potential major source of infection in patients undergoing extracorporeal membrane oxygenation (ECMO). This study aimed to describe the epidemiology of CRI among critically ill patients supported by ECMO and found that diabetes and ECMO duration were independently associated with CRI.
Article
Public, Environmental & Occupational Health
Luciana Rodrigues Pires de Campos, Marina Farrel Cortes, Beatriz Deo, Camila Rizek, Sania Santos, Lauro Perdigao, Silvia Figueiredo Costa
Summary: Mechanical ventilation, surgery, and hemodialysis are independent risk factors for multidrug-resistant bloodstream infections in critically ill trauma patients. Carbapenemase (KPC) is the main mechanism of resistance, and cross-transmission may contribute to its spread.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Medicine, General & Internal
Sally B. Coburn, Elizabeth Humes, Raynell Lang, Cameron Stewart, Brenna C. Hogan, Kelly A. Gebo, Sonia Napravnik, Jessie K. Edwards, Lindsay E. Browne, Lesley S. Park, Amy C. Justice, Kirsha S. Gordon, Michael A. Horberg, Julia M. Certa, Eric Watson, Celeena R. Jefferson, Michael J. Silverberg, Jacek Skarbinski, Wendy A. Leyden, Carolyn F. Williams, Keri N. Althoff
Summary: This study aims to estimate the rate and risk of breakthrough infections among fully vaccinated people with HIV (PWH) and people without HIV (PWoH) in the United States. The results showed that PWH had a higher risk of breakthrough infections compared with PWoH. Therefore, the expansion of recommendations for additional vaccine doses to all PWH should be considered.
Article
Dentistry, Oral Surgery & Medicine
Niina Rautaporras, Jussi Furuholm, Johanna Uittamo, Mikko Saloniemi, Tuukka Puolakka, Johanna Snall
Summary: Deep odontogenic infection is associated with the occurrence of pneumonia, with factors such as duration of mechanical ventilation and length of hospital stay significantly correlating with pneumonia. Re-intubation and smoking are also closely associated with pneumonia. Prompt and adequate treatment of OI should be administered to reduce duration of mechanical ventilation, and smokers with OI have a significantly higher risk of developing pneumonia.
CLINICAL ORAL INVESTIGATIONS
(2021)