Review
Medicine, General & Internal
Mian-Li Li, Xin-Xin Hong, Wei-Jian Zhang, Yi-Zhong Liang, Tian-Tian Cai, Yi-Fei Xu, Hua-Feng Pan, Jian-Yuan Kang, Shao-Ju Guo, Hai-Wen Li
Summary: Heliobacter pylori infection is associated with chronic gastritis, gastric mucosal atrophy, and gastric cancer. Spasmolytic polypeptide-expressing metaplasia (SPEM) is a type of mucous cell metaplasia that may have a stronger association with gastric adenocarcinoma than intestinal metaplasia. SPEM is caused by acute injury or inflammation and is characterized by abnormal expression of certain proteins in the stomach glands. The specific mechanism of SPEM progression driven by H. pylori infection needs further investigation.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Plant Sciences
Mengyuan Xiong, Xiantao Chen, Hongmei Wang, Xiang Tang, Qiaojiao Wang, Xuegang Li, Hang Ma, Xiaoli Ye
Summary: This study found that Zuojin capsule (ZJC) can improve spasmolytic polypeptide-expressing metaplasia (SPEM) and alleviate its symptoms such as gastric mucosal damage, hyperplasia of gastric pits, and increased gastric mucus secretion. The study also revealed that ZJC exerts its therapeutic effects by inhibiting the abnormal activation of cell cycle-related proteins (CDK1, CCNB1, CCNA2) and the PI3K-AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Pathology
Yasuhiro Wada, Shigemi Nakajima, Ryoji Kushima, Shizuki Takemura, Naoko Mori, Hiroshi Hasegawa, Takahisa Nakayama, Ken-ichi Mukaisho, Akiko Yoshida, Shinji Umano, Kazuo Yamamoto, Hiroyuki Sugihara, Kazunari Murakami
Summary: There are two types of pyloric gland-like metaplasia in the corpus of stomach: pyloric and pseudopyloric metaplasias. While they share similarities in morphology, there are differences in immunohistochemical expression of TFF2. The majority of metaplasia in autoimmune gastritis is pyloric metaplasia, with differences in TFF2 expression between pyloric and pseudopyloric metaplasia.
Article
Biochemistry & Molecular Biology
Megan D. Radyk, Lillian B. Spatz, Bianca L. Pena, Jeffrey W. Brown, Joseph Burclaff, Charles J. Cho, Yan Kefalov, Chien-Cheng Shih, James A. J. Fitzpatrick, Jason C. Mills
Summary: ATF3 and RAB7B are upregulated in the early Stage 1 of paligenosis to help cells induce autophagic and lysosomal mechanisms. Atf3(-/-) mice fail to induce autophagic and lysosomal vesicles, leading to increased cell death. The evolutionarily conserved ATF3 gene orchestrates early paligenotic autodegradative events.
Article
Immunology
Lin Liu, Yang Wang, Yukun Zhao, Wei Zhang, Jiong Liu, Fengyun Wang, Ping Wang, Xudong Tang
Summary: Spasmolytic polypeptide expression metaplasia (SPEM) is a lesion in the corpus of the stomach closely associated with inflammations caused by H. pylori infection. It has been suggested as a dubious precancerous lesion of gastric cancer (GC), and further research on SPEM cell transdifferentiation and its underlying mechanisms could contribute to the development of new molecular targets for GC therapeutics. This study analyzed publications related to SPEM-GC using bibliometrics, identified research hotspots, and provided references for scientific researchers in related fields.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biology
Valerie P. O'Brien, Amanda L. Koehne, Julien Dubrulle, Armando E. Rodriguez, Christina K. Leverich, V. Paul Kong, Jean S. Campbell, Robert H. Pierce, James R. Goldenring, Eunyoung Choi, Nina R. Salama
Summary: This study reveals the significant impact of Hp infection on the progression of gastric precancerous lesions, using transgenic mice with active KRAS expression to mimic the process induced by Hp infection. Hp infection can exacerbate T-cell infiltration and macrophage polarization, leading to more metaplastic and dysplastic glands.
LIFE SCIENCE ALLIANCE
(2021)
Article
Gastroenterology & Hepatology
Hsuan Hsieh, Hsiao-Bai Yang, Bor-Shyang Sheu, Yao-Jong Yang
Summary: This study aimed to evaluate the histopathological pattern of H. pylori atrophic gastritis in children and the extent of precancerous lesions. The results showed that the prevalence rates of gastric glandular atrophy, intestinal metaplasia, and spasmolytic peptide-expressing metaplasia (SPEM) in children with H. pylori infection were 30.4%, 4.3%, and 8.7% respectively. SPEM and high-grade atrophy were more common in female patients.
Article
Cell Biology
Zhi-Feng Miao, Charles J. Cho, Zhen-Ning Wang, Jason C. Mills
Summary: Differentiated cells have evolved a conserved program called paligenosis to return to a stem or progenitor state and reenter the cell cycle for tissue repair. Key regulators of paligenosis, such as Ddit4 and Ifrd1, control different stages of the process, providing potential new insights for tissue regeneration and cancer therapy.
Editorial Material
Oncology
James R. Goldenring
Summary: Intestinal-type gastric cancer can arise from precancerous metaplastic lineages, specifically from spasmolytic polypeptide-expressing metaplasia (SPEM) cells. A recent study identified an activating Kras(G12D) mutation in SPEM cells, which propagated into adenomatous and cancerous lesions, suggesting that SPEM lineages can serve as a direct precursor for dysplasia and intestinal-type gastric cancer.
JOURNAL OF PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Du-Min Go, Seung Hyun Lee, Su-Hyung Lee, Sang-Ho Woo, Kibyeong Kim, Kyeongdae Kim, Kyu Seong Park, Jong-Hwan Park, Sang-Jun Ha, Woo Ho Kim, Jae-Hoon Choi, Dae-Yong Kim
Summary: In Helicobacter-induced gastritis, PD-L1 may play a role in regulating immune responses. Gastric classical DCs express significantly higher levels of PD-L1 compared to other immune cells. Furthermore, PD-L1-expressing DCs co-localize with T cells and show a positive correlation with H pylori infection.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Cell Biology
Mariela Artola-Boran, Angela Fallegger, Martina Priola, Rima Jeske, Tim Waterboer, Anders B. Dohlman, Xiling Shen, Sebastian Wild, Jiazhuo He, Mitchell P. Levesque, Shida Yousefi, Hans-Uwe Simon, Phil F. Cheng, Anne Mueller
Summary: The co-existence of Helicobacter pylori and Mycobacterium tuberculosis can affect each other's colonization and immune control in the human body, which should be taken into consideration in treatment decisions.
Article
Oncology
Wan-Qun Chen, Feng-Liang Tian, Jin-Wei Zhang, Xiao-Jun Yang, Yan-Ping Li
Summary: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. YWXY is able to inhibit cell proliferation and restore miR-7 expression by mediating TFF2 in the SPEM mouse model.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Kadima Nayara Teixeira, Fabricio Freire de Melo
Summary: Gastric mucosa-associated lymphoid tissue lymphoma (GML) is a low-grade B-cell neoplasia commonly associated with chronic gastritis induced by Helicobacter pylori (H. pylori) infection. However, a subset of GML patients are H. pylori-negative. Despite previous beliefs, it has been found that a considerable proportion of H. pylori-negative GML patients show complete remission after bacterial eradication therapy. The mechanisms underlying this treatment responsiveness are not fully understood, and further research is needed to establish the causal relationship between non-H. pylori gastric helicobacters (NHPHs) and GML.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Junhua Xie, Qiqiong Li, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: This article reviews the recent advances and obstacles in the use of bacterial extracellular vesicles (bEVs) in biomedical applications, and discusses the paths towards clinical translation.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Microbiology
Robin Temmerman, Mahdi Ghanbari, Gunther Antonissen, Gerd Schatzmayr, Luc Duchateau, Freddy Haesebrouck, An Garmyn, Mathias Devreese
Summary: Fluoroquinolone agents are critical for human medicine, but their use in poultry production may contribute to the spread of antibiotic resistance genes. This study used metagenomics to investigate the effects of fluoroquinolone application in the gut microbiome of broiler chickens. The results showed that low-dose fluoroquinolone had the most significant impact on the chicken gut microbiota and resistome, while synbiotic supplementation alleviated the burden of antibiotic resistance genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tom Breugelmans, Wout Arras, Lauren-Emma Boen, Eliah Borms, Lisa Kamperdijk, Joris De Man, Els Van de Vijver, Ann Van Gils, Benedicte Y. De Winter, Nicolette Moes, Annemieke Smet
Summary: This study found that colonic mucin expression is disturbed in pediatric IBD patients and is associated with disease activity and presentation. These findings suggest that mucin expression can serve as a molecular marker to aid in the diagnosis and management of the disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemical Research Methods
Gurdeep Chahal, Medea Padra, Mattias Erhardsson, Chunsheng Jin, Macarena Quintana-Hayashi, Vignesh Venkatakrishnan, Janos Tamas Padra, Helen Stenback, Anders Thorell, Niclas G. Karlsson, Sara K. Linden
Summary: This study found that Helicobacter pylori infection in the stomach results in increased diversity and variation in glycan structures, primarily influenced by the binding ability of the BabA protein to fucosylated structures.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Cell Biology
George M. H. Birchenough, Bjoern O. Schroeder, Sinan Sharba, Liisa Arike, Christian V. Recktenwald, Fabiola Puertolas-Balint, Mahadevan V. Subramani, Karl T. Hansson, Bahtiyar Yilmaz, Sara K. Linden, Fredrik Backhed, Gunnar C. Hansson
Summary: Intestinal mucus barriers are important for preventing microbial infections but can be disrupted by a Western-style diet, leading to susceptibility to pathogen colonization.
Article
Gastroenterology & Hepatology
Nikita Hanning, Rosanne Verboven, Joris G. De Man, Hannah Ceuleers, Heiko U. De Schepper, Annemieke Smet, Benedicte Y. De Winter
Summary: This study showed that single-day or multi-day orogastric gavages do not have a significant effect on gut physiology in mice. However, multi-day gavages result in a slight increase in stress levels and altered gastrointestinal motor function. Despite this, the intestinal barrier function remains unaffected.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Junhua Xie, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: Bacterial extracellular vesicles (bEVs) have been shown to play a crucial role in the pathogenesis of various diseases. This article thoroughly discusses the contribution of bEVs in disease pathogenesis, their potential as diagnostic biomarkers, and their application as therapeutic targets.
TRENDS IN MICROBIOLOGY
(2023)
Article
Microbiology
Baptiste Oosterlinck, Hannah Ceuleers, Wout Arras, Joris G. De Man, Karen Geboes, Heiko De Schepper, Marc Peeters, Sarah Lebeer, Jurgita Skieceviciene, Georgina L. Hold, Juozas Kupcinskas, Alexander Link, Benedicte Y. De Winter, Annemieke Smet
Summary: This study identified the mucin-microbiome signatures in gastric adenocarcinomas and their impact on clinical outcomes. The findings showed that intestinal mucin phenotype and high-level MUC13 expression were associated with poor survival, while gastric MUC5AC or MUC6 abundance was associated with a more favorable outcome. Furthermore, oral bacteria such as Neisseria, Prevotella, and Veillonella were found to play a potential role in MUC13 signaling and were associated with intestinal and mixed mucin phenotype tumors.
Article
Cell Biology
Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michael Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Summary: This study investigates the role of MUC13 in disrupting epithelial barrier integrity and the involvement of MUC1 in inflammatory bowel diseases (IBD). The results demonstrate that MUC13 overexpression affects the expression of junctional proteins and barrier mediators, leading to intestinal barrier dysfunction. Furthermore, MUC13 modulates several signaling pathways, including JAK1/STAT3, SNAI1/ZEB1, and ROCK2/MAPK, in cooperation with MUC1. The findings suggest that aberrant MUC13 signaling plays an active role in inducing intestinal barrier dysfunction during inflammation.
Article
Microbiology
Kim Stobbelaar, Thomas C. Mangodt, Winke Van der Gucht, Lise Delhaise, Jasmine Andries, Valerie Gille, Cyril Barbezange, Annemieke Smet, Benedicte Y. De Winter, Jozef J. De Dooy, Tom Schepens, Els L. I. M. Duval, Paul Cos, Philippe G. Jorens, Stijn Verhulst, Peter L. Delputte
Summary: The respiratory syncytial virus (RSV) is the leading cause of viral lower respiratory tract infections (LRTI) in children worldwide, and is associated with significant morbidity and mortality rates. This study found that patients with a single RSV infection had higher disease severity compared to patients with RSV co-infections, suggesting that the presence of viral co-infections could influence the course of RSV bronchiolitis. Further investigation is needed to guide physicians in early treatment decisions for patients who may benefit from current or future treatment options.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Francisco Cortez Nunes, Emily Taillieu, Teresa Letra Mateus, Silvia Teixeira, Freddy Haesebrouck, Irina Amorim
Summary: This study aimed to assess the presence of antibiotic resistance genes previously reported in Helicobacter pylori in gastric samples from 36 pigs where DNA of H. pylori-like organisms had been detected. Based on PCR and sequencing analysis, two samples were positive for the 16S rRNA mutation gene conferring tetracycline resistance, and one sample was positive for the frxA gene conferring metronidazole resistance. These findings indicate the potential occurrence of acquired antimicrobial resistance in H. pylori-like organisms associated with pigs.
Article
Biochemistry & Molecular Biology
Etty Bachar-Wikstrom, Kristina A. Thomsson, Carina Sihlbom, Lisa Abbo, Haitham Tartor, Sara K. Linden, Jakob D. Wikstrom
Summary: This study explored the structure and composition of shark skin mucus through histological analysis and glycan profiling. Results showed that shark skin has a functional mucus layer similar to bony fish, although thinner. The glycans in shark skin mucus differ significantly from bony fish, particularly in being more sulfated, and some bear resemblance to human glycans. This study is important for understanding the unique properties of shark skin and further investigating the functional roles and potential biomedical implications of shark skin mucus glycans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Etty Bachar-Wikstrom, Braham Dhillon, Navi Gill Dhillon, Lisa Abbo, Sara K. Linden, Jakob D. Wikstrom
Summary: This pilot study examines the protein composition of shark skin mucus using mass spectrometry. The results show that the majority of the proteins are cellular, but there is also a significant portion of secreted proteins with mucosal immune roles. Protein-protein association network analysis suggests that closely related shark species have more similar proteins compared to more distantly related sharks and bony fish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vignesh Venkatakrishnan, Kristina A. Thomsson, Medea Padra, Anders Andersson, Bettina Brundin, Karin Christenson, Johan Bylund, Niclas G. Karlsson, Anders Linden, Sara K. Linden
Summary: Long-term smokers exhibit significant alterations in N-glycosylation in the lungs, and the hybrid N-glycans identified only in long-term smokers with COPD deserve further study as potential biomarkers.
Review
Gastroenterology & Hepatology
Tom Breugelmans, Baptiste Oosterlinck, Wout Arras, Hannah Ceuleers, Joris De Man, Georgina L. Hold, Benedicte Y. De Winter, Annemieke Smet
Summary: Mucins play a crucial role in the gastrointestinal mucosal barrier and are involved in bidirectional interactions with the gut microbiota. They are also associated with various cell signaling pathways and have potential applications in the diagnosis, follow-up, and treatment of gastrointestinal diseases.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)