Article
Infectious Diseases
James S. Molton, I. Russel Lee, Denis Bertrand, Ying Ding, Shirin Kalimuddin, David C. Lye, Niranjan Nagarajan, Yunn-Hwen Gan, Sophia Archuleta
Summary: The study found that hypermucoviscous Klebsiella pneumoniae could potentially be shared among household members, indicating a potential transmission risk of hypermucoviscous strains within households.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Emergency Medicine
Genevieve S. Pentecost, Jacob Kesterson
Summary: Invasive Liver Abscess Syndrome, caused by Klebsiella pneumoniae, is a manifestation of systemic infection. Although common in Southeast Asia, it is uncommon in the United States. This article presents a case of pyogenic liver abscess and associated endogenous endophthalmitis in a patient presenting to the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Zhijie Zhang, Hairui Wang, Yawen Guo, Zhaoyu Liu, Zhihui Chang
Summary: This study found significant differences in bacterial characteristics between IKPLA and KPLA, including microbiological changes, activation of related metabolic pathways, and expression of pathogenic genes. These differences provide clues for exploring the mechanism of invasiveness in KPLA.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Yahong Zheng, Chengcheng Yue, Hui Zhang, Haoran Chen, Yanyan Liu, Jiabin Li
Summary: The study revealed that secondary bile acids (SBAs) protect the liver and inhibit inflammation in Klebsiella pneumoniae-induced liver abscess and bacteremia by modulation of the NF-κB inflammatory signaling pathway via TGR5.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Dakang Hu, Wenjie Chen, Weiwen Wang, Dongxing Tian, Pan Fu, Ping Ren, Qing Mu, Gang Li, Xiaofei Jiang
Summary: This study aims to investigate the mechanisms of Klebsiella pneumoniae-induced pyogenic liver abscess (PLA). Differences were found between K. pneumoniae strains from PLA and non-PLA samples for virulence genes and factors. Hypercapsule production is the cornerstone of hypervirulence, regardless of exopolysaccharides. K. pneumoniae-induced PLA may decrease core inflammatory cytokines rather than increase anti-inflammatory cytokines. Exopolysaccharides could also attenuate the inflammatory response to aid in the immune escape of K. pneumoniae.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Jorge Cardenas-Alvarez, Galit Balayla, Abel Triana, Rodrigo Lankenau, Carlos Franco-Paredes, Andres F. Henao-Martinez, Gabriel Motoa
Summary: This scoping review provides an overview of the characteristics and clinical presentations of cryptogenic Klebsiella pneumoniae liver abscess in the Americas. The majority of cases involve males with diabetes who have traveled from Southeast or East Asia. Extrahepatic involvement and bacteremia are common, with the lungs, ocular structures, and central nervous system being commonly affected. Treatment includes percutaneous drainage and the use of third generation cephalosporins, but the pooled fatality rate remains at 9%.
Article
Immunology
Yahong Zheng, Yuting Ding, Mengran Xu, Haoran Chen, Hui Zhang, Yanyan Liu, Weihua Shen, Jiabin Li
Summary: The study identified the gut microbiota as a protective factor against K. pneumoniae infection, and found that FMT could improve inflammatory levels and liver damage in KLA patients, increasing survival rates.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Microbiology
Changrui Qian, Siqin Zhang, Mengxin Xu, Weiliang Zeng, Lijiang Chen, Yining Zhao, Cui Zhou, Ying Zhang, Jianming Cao, Tieli Zhou
Summary: This study investigated the phenotypic and genotypic characteristics of multidrug resistant liver abscess-causing Klebsiella pneumoniae (MDR LAKp) strains from 2016 to 2020. The majority of these strains exhibited resistance to cephalosporins, quinolones, and chloramphenicol, but only half displayed higher virulence than classical MDR strain. Three hypervirulent carbapenem-resistant strains carrying bla(KPC-2) and one colistin-resistant strain carrying mcr-1 were identified. Phylogenetic analysis showed that most MDR LAKp strains belonged to clade 1. This study provides insights into MDR LAKp and highlights the need for prevention measures to control their spread.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Kuan-Jen Chen, Yen-Po Chen, Yi-Hsing Chen, Laura Liu, Nan-Kai Wang, An-Ning Chao, Wei-Chi Wu, Yih-Shiou Hwang, Hung-Da Chou, Eugene Yu-Chuan Kang, Yen-Ting Chen, Ming-Hui Sun, Chi-Chun Lai
Summary: This study investigates the infection sources and antibiotic susceptibilities of Klebsiella pneumoniae in patients with endogenous K. pneumoniae endophthalmitis in Northern Taiwan. Pyogenic liver abscess was identified as the major infection source, and K. pneumoniae showed high susceptibility to ceftazidime and amikacin.
Review
Microbiology
Kai Siang Chan, Christopher Tze Wei Chia, Vishal G. Shelat
Summary: KPPLA patients are younger with a lower prevalence of hepatobiliary disease and malignancy. KPPLA is associated with a lower incidence of multiple and bilobar abscesses, but higher overall metastatic complications. In terms of mortality, KPPLA has a lower rate compared to N-KPPLA.
Article
Biochemistry & Molecular Biology
Jinyin Wu, Jie Chen, Ying Wang, Qingtai Meng, Jizi Zhao
Summary: The siderophore aerobactin (iucA) plays an important role in the formation of pyogenic liver abscess caused by hypermucoviscosity/hypervirulent K. pneumoniae (hvKP). This study showed that iucA deletion led to decreased virulence of hvKP852 strain in mice and reduced reactive oxygen stress levels in liver tissue, indicating the significance of iucA in the pathogenesis of liver abscess.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Medicine, General & Internal
Joo-Hee Hwang, Jeong-Hwan Hwang, Seung Yeob Lee, Jaehyeon Lee
Summary: This study investigated the clinical and microbiological characteristics of prostatic abscesses caused by Klebsiella pneumoniae. The results showed that a particular hypervirulent strain of K. pneumoniae, associated with the K1 capsular type and the presence of the rmpA and iutA genes, was an important pathogen in prostatic abscesses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Lin Gan, Chao Yan, Jinghua Cui, Guanhua Xue, Hanyu Fu, Bing Du, Hanqing Zhao, Junxia Feng, Yanling Feng, Zheng Fan, Pan Mao, Tongtong Fu, Ziying Xu, Shuheng Du, Shiyu Liu, Rui Zhang, Qun Zhang, Nannan Li, Xiaohu Cui, Xiaoran Li, Yao Zhou, Lei Huang, Jing Yuan
Summary: Klebsiella pneumoniae, a common cause of nosocomial and community-acquired infections, including pneumonia and pyogenic liver abscess, has little known about its population structure. This study investigated the prevalence and characteristics of K. pneumoniae isolates from carriers, pyogenic liver abscess patients, and pneumonia patients. The isolates from different sources had their own sequence types and genomic features. The isolates from liver abscess patients carried more virulence factors, while those from pneumonia patients harbored more resistance genes and replicons. The isolates from liver abscesses also showed higher virulence. The findings suggest that isolates from different sources have distinct genomic features and may infect different patients via different sources.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Hairui Wang, Yawen Guo, Zhaoyu Liu, Zhihui Chang
Summary: By analyzing abscess samples, the study found that the type VI secretion system (T6SS) is involved in the pathogenesis of invasive Klebsiella pneumoniae liver abscess (IKPLA). PCR and RT-PCR experiments confirmed the expression difference of T6SS hallmark genes and identified the pathogenic feature of T6SS. The results suggest that T6SS is an essential virulence factor for K pneumoniae and contributes to IKPLA.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Yu Chang, Jiann-Hwa Chen, Wei-Lung Chen, Jui-Yuan Chung
Summary: A rare case of invasive liver abscess and meningitis caused by Klebsiella pneumoniae was reported. Patients with diabetes mellitus are at higher risk for this disease, especially in Asia. The clinical presentation mimics acute stroke and requires aggressive treatment.
BMC INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Wei-Chan Hsu, Fu-Chen Yang, Chi-Hung Lin, Shie-Liang Hsieh, Nien-Jung Chen
CELLULAR SIGNALLING
(2014)
Article
Infectious Diseases
J. J. Yan, J. J. Wu, C. C. Lee, W. C. Ko, F. C. Yang
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2010)
Article
Microbiology
Fu-Chen Yang, Jing-Jou Yan, Kuei-Hsiang Hung, Jiunn-Jong Wu
JOURNAL OF CLINICAL MICROBIOLOGY
(2012)
Article
Immunology
Ke-Hsun Hsu, Chin-Wen Wei, Yi-Ru Su, Tung Chou, Yueh-Ling Lin, Fu-Chen Yang, Ann-Ping Tsou, Chia-lin Hsu, Ping-Hui Tseng, Nien-Jung Chen, Kuo-Shyang Jeng, Chuen-Miin Leu
IMMUNOLOGY LETTERS
(2020)
Article
Cardiac & Cardiovascular Systems
Hsin-Lei Huang, Chin-Sung Kuo, Ting-Yung Chang, Ruey-Hsing Chou, I-Chun Chen, Fu-Chen Yang, Nien-Jung Chen, Shing-Jong Lin, Chih-Cheng Wu, Po-Hsun Huang
Summary: This study showed that oral administration of AST-120 reduced the serum levels of AGEs in diabetic mice and improved the blood flow recovery in ischemic limbs, potentially through alterations in macrophage polarization and associated changes in inflammatory cytokines.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elise Loppinet, Harrison A. Besser, Agnele Sylvia Sewa, Fu-Chen Yang, Bana Jabri, Chaitan Khosla
Summary: Celiac disease is caused by gluten-derived antigens triggering inflammation through presenting to CD4+ T cells. In this study, we propose a mechanism for the deamidation and concentration of gluten peptides in the lysosomes of antigen-presenting cells, which explains the high concentration of gluten peptides required for an inflammatory response in CeD patients. We found that a ternary complex formed between a gluten peptide, transglutaminase-2 (TG2), and a2-macroglobulin, which was endocytosed by LRP-1. The covalent TG2-peptide adduct underwent endolysosomal decoupling, resulting in the expected deamidated epitope. Our findings suggest a pathogenic role for dendritic cells and/or macrophages in CeD and implicate TG2 in the lysosomal clearance of unwanted proteins.
CELL CHEMICAL BIOLOGY
(2023)
Article
Cell Biology
Fu-Chen Yang, Po-Yuan Chiu, Yun Chen, Tak W. Mak, Nien-Jung Chen
JOURNAL OF BIOMEDICAL SCIENCE
(2019)