Article
Immunology
Reza Gheitasi, Fariba Keramat, Sara Khosravi, Mehrdad Hajilooi, Mathias W. Pletz, Oliwia Makarewicz
Summary: This study investigated the expression levels of Th2 and Th17 immunity-related factors in different stages of Brucella infections. The results showed that Th2-LCR lncRNA and TRAF3IP2 might be good indicators of acute brucellosis, while IL-25 and IL-17RB failed to differentiate between infected and non-infected groups. Further studies on larger cohorts with well-defined inclusion criteria are needed to verify the suitability of these factors as indicators for brucellosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shubham Mathur, Menachem Banai, Dani Cohen
Summary: In this study, it was found that serum antibodies against Brucella O-polysaccharide (OPS) generated after vaccination or natural infection can kill Brucella in vitro. The complement bactericidal activity was significantly higher in sera containing OPS IgG antibodies compared to sera lacking such antibodies.
Article
Environmental Sciences
Mingcui Ding, Chengpeng Zhang, Wei Wang, Pengpeng Wang, Yangqing Pei, Na Wang, Shan Huang, Changfu Hao, Wu Yao
Summary: Exosomal miR-125a-5p promotes the development of silicosis by targeting TRAF6 to regulate T cell differentiation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Stefano Piazza, Marco Fumagalli, Giulia Martinelli, Carola Pozzoli, Nicole Maranta, Marco Angarano, Enrico Sangiovanni, Mario Dell'Agli
Summary: Plants rich in hydrolyzable tannins have traditionally been used for the treatment of chronic inflammatory disorders. However, limited knowledge of their immunological targets hinders their rational use in phytotherapy. Recent advances in understanding the pathogenesis of inflammatory-based diseases provide an opportunity to elucidate the pharmacological mechanisms of these plant-derived metabolites with immunomodulatory activity. This review summarizes recent articles on the role of hydrolyzable tannins and their gut metabolites in various inflammatory responses.
Article
Immunology
Mengxian Zhou, Ruyi Qu, Xuewei Yin, Yan Qiu, Yuan Peng, Bin Liu, Yane Gao, Hongsheng Bi, Dadong Guo
Summary: In this study, the regulatory effects of prednisone acetate (PA) on the Th1/Th2 and Th17/Treg balance in experimental autoimmune uveitis (EAU) through modulating the Notch signaling pathway were investigated. The results showed that activation of the Notch signaling pathway resulted in a severe imbalance of the Th17/Treg and Th1/Th2 ratios, while PA treatment significantly alleviated ocular inflammation, inhibited activation of the Notch signaling pathway, and restored the Th1/Th2 and Th17/Treg balance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Haiyan Bian, Lisheng Wang, Chengwen Gao, Zhihe Liu, Yang Sun, Minghui Hu, Yujing Xiao, Fengyun Hao, Yushuo Ma, Xia Zhao
Summary: This study explores the expression and clinical significance of Th1/Th2/Th17 cytokines and lymphocyte subsets in patients with Primary central nervous system lymphoma (PCNSL). The results show significant differences in cytokines and lymphocyte subsets between PCNSL patients, diffuse large B-cell lymphoma (DLBCL) patients, and healthy controls. These findings provide valuable information for the diagnosis, treatment, and prognosis of PCNSL.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Wenjing Chen, Yuxue Cao, Yuanyuan Zhong, Jing Sun, Jingcheng Dong
Summary: CD4(+) helper T cell subsets play a critical role in the pathogenesis of asthma. Different subsets of Th cells differentiate under the stimulation of different cytokines and are driven by lineage-specific transcription factors. The balance between effector Th cell response and Treg cell immunosuppression is essential for maintaining immune homeostasis and understanding the immunopathological mechanism of asthma. Recent studies have found that certain factors involved in effector Th cell response also contribute to the development and function of Treg cells. This review aims to summarize the role of these factors in Treg cell development and function to gain new insights into the immunopathological mechanism and potential therapy strategies of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Constantin Schmidt, Aenne Harberts, Daniel Reimers, Tabea Bertram, Leonie Caroline Voss, Joanna Schmid, Niels Christian Lory, Michael Spohn, Friedrich Koch-Nolte, Samuel Huber, Friederike Raczkowski, Minka Breloer, Hans-Willi Mittruecker
Summary: The transcription factor IRF4 plays a central role in controlling T cell activation and differentiation. Deficiency of IRF4 results in severe immune deficiency, impaired T cell maturation and function, and compromised control of pathogens. The study shows that IRF4 is vital for Th17 and Th2 cell responses and the recruitment of T helper cells to the intestine. IRF4 regulates the expression of intestinal homing receptors and is essential for Th2 and Th17 cell differentiation and migration to the intestine.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Raquel Gomez-Bris, Angela Saez, Beatriz Herrero-Fernandez, Cristina Rius, Hector Sanchez-Martinez, Jose M. Gonzalez-Granado
Summary: Inflammatory bowel disease (IBD) refers to chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, presenting as Crohn's disease (CD) or ulcerative colitis (UC). It is characterized by exacerbated innate and adaptive immunity in the gut, along with microbiota dysbiosis and disruption of the intestinal barrier, leading to increased bacterial exposure. CD4 T-cells play a crucial role in the development of IBD, with various phenotypes and interactions with other immune cells determining the progression of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Summary: Despite long-term control efforts, hepatic coccidiosis caused by Eimeria stiedai infection remains persistent in rabbits in China. This study provides the first evidence of changes in Th1/Th2/Treg/Th17/Th9/Th21 cells in rabbits infected with E. stiedai, offering insights into immune regulation mechanisms and potential vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Andrea Itano, Douglas Maslin, Kritika Ramani, Golbarg Mehraei, Nancy Carpenter, Taylor Cormack, Mahdi Saghari, Matthijs Moerland, Erin Troy, Will Caffry, Leslie Wardwell-Scott, Stuart Abel, Duncan McHale, Mark Bodmer
Summary: This study introduces EDP1815, a non-colonizing pharmaceutical preparation derived from a single strain of Prevotella histicola. The research demonstrates that EDP1815 can regulate inflammatory responses throughout the body when taken orally and restricted to the gut.
FRONTIERS IN MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yee Huang, Li Nan, Chenwen Xiao, Jie Dong, Ke Li, Jvfen Cheng, Quanan Ji, Qiang Wei, Guolian Bao, Yan Liu
Summary: The study successfully developed GAN-OMV, which can stimulate Th1/Th2/Th17 immune responses against Bb and provide a promising strategy for novel vaccine development against the microbial pathogen. GAN-OMV showed a stable core-shell structure and effectively internalized into macrophages through multiple endocytotic pathways, promoting cell proliferation, cytokine secretion, and M1 polarization. Subcutaneous GAN-OMV vaccination significantly enhanced specific antibody production, lymphocyte proliferation, and the production of Th1/Th2/Th17 cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Immunology
Caroline La, Berengere de Toeuf, Laure B. Bindels, Laurye Van Maele, Assiya Assabban, Maxime Melchior, Justine Smout, Arnaud Kohler, Muriel Nguyen, Severine Thomas, Romuald Soin, Nadege Delacourt, Hsuehlei Li, Wenqian Hu, Perry J. Blackshear, Veronique Kruys, Cyril Gueydan, Guillaume Oldenhove, Stanislas Goriely
Summary: Studies on Zfp36(-/-) mice revealed that despite the absence of histological signs of gut pathology, there was an increase in intestinal inflammatory markers and alterations in microbiota composition. Oral antibiotic treatment reduced joint and skin inflammation, with the expansion of regulatory T cells associated with increased vitamin A metabolism by gut dendritic cells.
MUCOSAL IMMUNOLOGY
(2021)
Article
Microbiology
Leticia Lazaro-Anton, Maria Jesus de Miguel, Thibault Barbier, Raquel Conde-Alvarez, Pilar M. Munoz, Jean Jacques Letesson, Maite Iriarte, Ignacio Moriyon, Amaia Zuniga-Ripa
Summary: The study investigated the sugar metabolism pathways in Brucella suis biovar 5, showing that it utilizes both the Pentose Phosphate shunt and the Entner-Doudoroff pathway. Mutants lacking key enzymes in these pathways displayed reduced growth rates, indicating the importance of these pathways for bacterial growth. However, the triple mutant was still able to multiply within host cells, suggesting anabolic use of other pathways in Brucella suis biovar 5.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Aurore Le, Abdulkader Azouz, Severine Thomas, Nicolas Istaces, Muriel Nguyen, Stanislas Goriely
Summary: The study revealed that JNK1 plays a crucial role in inflammatory skin diseases, regulating the production of inflammatory cytokines by myeloid cells and the sensitivity of keratinocytes to EGFR ligands. These findings suggest that JNK1 could be a valuable therapeutic target in the treatment of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Matthias Vanderkerken, Antonio P. Baptista, Marco De Giovanni, Satoshi Fukuyama, Robin Browaeys, Charlotte L. Scott, Paula S. Norris, Gerard Eberl, James P. Di Santo, Eric Vivier, Yvan Saeys, Hamida Hammad, Jason G. Cyster, Carl F. Ware, Alexei Tumanov, Carl De Trez, Bart N. Lambrecht
Summary: LT alpha(1)beta(2)-expressing Rorgt(+) ILC3s, together with B cells, control the splenic cDC niche size and the terminal differentiation of Sirp alpha(+)CD4(+)Esam(+) cDC2s. ILC3s play a critical role as perpetual regulators of lymphoid tissue homeostasis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Infectious Diseases
Dimitri Bulte, Lieselotte Van Bockstal, Laura Dirkx, Magali Van den Kerkhof, Carl De Trez, Jean-Pierre Timmermans, Sarah Hendrickx, Louis Maes, Guy Caljon
Summary: The study found that MIL-R parasites induce a strong innate immune response, leading to compromised infectivity in the host, but MIL can partially restore their infectivity. Additionally, MIL may exacerbate infections with resistant parasites by reducing innate immune recognition.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Aurore Demars, Armelle Vitali, Audrey Comein, Elodie Carlier, Abdulkader Azouz, Stanislas Goriely, Justine Smout, Veronique Flamand, Megane Van Gysel, Johan Wouters, Jan Abendroth, Thomas E. Edwards, Arnaud Machelart, Eik Hoffmann, Priscille Brodin, Xavier De Bolle, Eric Muraille
Summary: Brucellosis is a common bacterial zoonosis worldwide. The Acod1 gene plays a key role in controlling pulmonary Brucella infection in mice. The ACOD1 enzyme converts cis-aconitate to itaconate and may be a potential target for pharmacological interventions in treating early stages of pulmonary Brucella infection.
Review
Food Science & Technology
Mahta Mirzaei, Amin Shavandi, Saeed Mirdamadi, Nazila Soleymanzadeh, Paria Motahari, Niloofar Mirdamadi, Muriel Moser, Gilles Subra, Houman Alimoradi, Stanislas Goriely
Summary: Yeast cells are a rich source of proteins and bioactive peptides with multiple functionalities. While research on yeast extract has increased, there is a lack of systematic review on the functional properties attributed to bioactive peptides content and production methods. Predicting and designing new peptide sequences can effectively transfer research findings into practical market applications.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Immunology
Benoit Stijlemans, Maxime Schoovaerts, Patrick De Baetselier, Stefan Magez, Carl De Trez
Summary: African trypanosome infection can lead to a seesaw balance between protective immunity and excessive inflammation, with the roles of macrophage migration inhibitory factor (MIF) and interleukin-10 (IL-10) being crucial in modulating the host immune microenvironment. Blocking MIF and promoting IL-10 receptor signaling pathways could potentially be used as therapy to counteract immunopathology development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Elisa Brauns, Abdulkader Azouz, David Grimaldi, Hanxi Xiao, Severine Thomas, Muriel Nguyen, Veronique Olislagers, Ines Vu Duc, Carmen Orte Cano, Veronique Del Marmol, Pieter Pannus, Frederick Libert, Sven Saussez, Nicolas Dauby, Jishnu Das, Arnaud Marchant, Stanislas Goriely
Summary: Severe COVID-19 disease can lead to dysregulation of the myeloid compartment during acute infection. In this study, impaired cytokine production by monocytes was observed in patients with severe COVID-19 during the acute phase, but was restored in convalescent patients. However, recovered patients showed increased responsiveness to TLR1/2 ligation, suggesting different functional properties of these cells at different stages of the disease.
Review
Microbiology
Edgardo Moreno, Jose Maria Blasco, Jean Jacques Letesson, Jean Pierre Gorvel, Ignacio Moriyon
Summary: This article highlights the importance of differentiating between the genera Brucella and Ochrobactrum in taxonomy, emphasizing the divergences in lifestyle, structure, physiology, genomics, and pathogenicity. It warns against merging the two genera due to the significant risks it poses to veterinarians, medical doctors, and public health authorities in dealing with brucellosis, a major zoonotic disease worldwide.
Article
Immunology
Isabel Vogel, Valerie Acolty, Tibor Keler, Stanislas Goriely, Oberdan Leo, Muriel Moser
Summary: CD27/CD70 costimulation enhances T-cell function and suppresses IL-17 production, suggesting its potential as a therapeutic target for diseases characterized by excessive IL-17 production.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Microbiology
Georges Potemberg, Aurore Demars, Emeline Barbieux, Angeline Reboul, Francois-Xavier Stubbe, Malissia Galia, Maxime Lagneaux, Audrey Comein, Olivier Denis, David Perez-Morga, Jean-Marie Vanderwinden, Xavier De Bolle, Eric Muraille
Summary: By analyzing the Brucella genome and lung infection, it was found that the immune status determines the genes required for optimal growth and survival of Brucella in vivo.
Article
Oncology
Avery C. Lee, Sai Ravi Pingali, Javier A. Pinilla-Ibarz, Michael L. Atchison, Constantinos Koumenis, Yair Argon, Andrei Thomas-Tikhonenko, Carl De Trez, Chih-Chi Andrew Hu, Chih-Hang Anthony Tang
Summary: In this study, we found that the loss of activation-induced cytidine deaminase (AID) leads to worsened B cell chronic lymphocytic leukemia (CLL). AID-deficient CLL cells exhibit increased endoplasmic reticulum stress response and support leukemic growth through the IRE1/XBP1s pathway. Additionally, AID deficiency alters the tumor suppressive SMAD1/S1PR2 pathway and CLL cell homing. Patients with IgHV-unmutated CLL express higher levels of XBP1s mRNA compared to those with IgHV-mutated CLL.
Article
Biochemistry & Molecular Biology
Jeremy Verbeke, Youri Fayt, Lisa Martin, Oya Yilmaz, Jaroslaw Sedzicki, Angeline Reboul, Michel Jadot, Patricia Renard, Christoph Dehio, Henri-Francois Renard, Jean-Jacques Letesson, Xavier De Bolle, Thierry Arnould
Summary: The facultative intracellular pathogen Brucella abortus interacts with host cell organelles, particularly the mitochondria, for replication. This study demonstrates that B. abortus induces fragmentation of the mitochondrial network, mitophagy, and the formation of mitochondrial Brucella-containing vacuoles during late stages of cellular infection. This process is dependent on the expression of the mitophagy receptor BNIP3L, which is regulated by iron-dependent stabilization of hypoxia-inducible factor 1 alpha. BNIP3L-mediated mitophagy is advantageous for bacterial exit from the host cell. These findings highlight the intricate relationship between Brucella trafficking and the mitochondria during host cell infection.
Article
Allergy
L. de Montjoye, A-S Darrigade, A. Gimenez-Arnau, A. Herman, L. Dumoutier, M. Baeck
Summary: This study found that CRP, D-dimer serum/plasma levels, and blood basophil counts in CSU patients may be correlated to disease activity, treatment response, and/or autoimmune status.
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)