Article
Respiratory System
Indiwari Gopallawa, Li Eon Kuek, Nithin D. Adappa, James N. Palmer, Robert J. Lee
Summary: The study shows that SC79 induces nitric oxide production, antioxidant gene transcription, reduces interleukin-8 transcription, and may protect airway epithelial cells against oxidative barrier dysfunction by activating the Akt pathway.
RESPIRATORY RESEARCH
(2021)
Article
Clinical Neurology
Saima Khatoon, Nidhi Bharal Agarwal, Mohammed Samim, Ozair Alam
Summary: This study demonstrates that fisetin exhibits neuroprotective effects in experimental epilepsy by suppressing the release of inflammatory and apoptotic molecules and attenuating histological alterations.
FRONTIERS IN NEUROLOGY
(2021)
Review
Immunology
Domenico Supino, Luna Minute, Andrea Mariancini, Federica Riva, Elena Magrini, Cecilia Garlanda
Summary: This article explores the roles of interleukin-1 (IL-1) family members and their receptors in regulating immune and inflammatory processes at the molecular level. It discusses their significance in the development of diseases and their potential therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hyun Ju Lee, Hyeon Ji Kim, Jung Hwa Ko, Joo Youn Oh
Summary: The depletion of CD11b(hi)Ly6G(hi) or CD11b(hi)Ly6C(hi)Ly6G(lo) cells aggravates corneal nerve loss in response to sterile corneal injury, while IL-6 neutralization preserves corneal nerves and reduces myeloid cell recruitment. The TLR2-IL-6 axis drives corneal nerve loss, and corneal stromal fibroblasts are involved in this process.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Microbiology
Hongdong Li, Xingyuan Li, Qing Ai, Liping Tan
Summary: This study found that the quorum sensing signal autoinducer-2 (AI-2) promotes acute lung infection caused by Pseudomonas aeruginosa through interfering with the quorum sensing system and the interleukin-17A (IL-17A) pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Katie A. Parsels, Keri A. Mastro, Jeffrey M. Steele, Stephen J. Thomas, Wesley D. Kufel
Summary: Cefiderocol is a novel siderophore cephalosporin that has shown activity against clinically relevant MDR Gram-negative bacteria. FDA-approved indications include complicated urinary tract infections and hospital-acquired bacterial pneumonia. Clinical trials have demonstrated non-inferiority to standard treatments, but higher all-cause mortality was observed in certain cases.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Aiping Ma, Liang Zhang, Xiaokai Ye, Jing Chen, Jie Yu, Liangjin Zhuang, Chaohang Weng, Frank Petersen, Zhanxiang Wang, Xinhua Yu
Summary: The study found a positive association between the duration of illness in patients with severe COVID-19 and serum levels of IL-8 and soluble IL-2R alpha, indicating the involvement of neutrophils and T cells in the evolution of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Physical
Jong Min An, Sangrim Kang, Chang Woo Koh, Sungnam Park, Myung Sook Oh, Dokyoung Kim
Summary: A new nano-antibiotic formulation based on sceptrin-Au nano-aggregates (SANA) has been developed to combat drug-resistant bacterial infections. SANA showed superior antibiotic/antibiofilm activity with low toxicity to red blood cells and endothelial cells. The feasibility of SANA as a new nano-antibiotic was demonstrated in CRPA-contaminated medical supplies.
NANOSCALE HORIZONS
(2022)
Article
Medicine, Research & Experimental
Tayyab Rehman, Philip H. Karp, Ping Tan, Brian J. Goodell, Alejandro A. Pezzulo, Andrew L. Thurman, Ian M. Thornell, Samantha L. Durfey, Michael E. Duffey, David A. Stoltz, Edward F. McKone, Pradeep K. Singh, Michael J. Welsh
Summary: Inflammation plays a key role in regulating HCO3- secretion in CF airways, affecting the pH of ASL. The study shows that inflammation leads to an increase in ASL pH, and CFTR modulators can further alkalize ASL. These findings suggest that airway inflammation is an important determinant of the response to CFTR modulators in CF airways.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Shaohui Zhang, Feng Chen, Feng Zhai, Shuli Liang
Summary: This review examines the association between epilepsy and neuroinflammatory responses, focusing on the roles of the HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways and their potential as biomarkers in the prediction, prognosis, and targeted therapy of epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Haoyang Li, Qinyao Li, Sheng Wang, Jianguo He, Chaozheng Li
Summary: Accumulation of ammonia nitrogen is considered as an environmental stress factor in aquaculture, increasing the susceptibility of aquatic organisms to infection. The study identified LvIL-1R-LvRelish axis as a mechanism for antibacterial signaling, and revealed the inhibitory effect of elevated ammonia-N concentration on this axis, providing insights into disease prevention and treatment in aquaculture.
Article
Medicine, Research & Experimental
Ying Zhang, Qinghui Zhuang, Fang Wang, Can Zhang, Chang Xu, Aiqin Gu, William H. Zhong, Yi Hu, Xiaosong Zhong
Summary: In this study, we successfully constructed CD19 specific armored CAR-T cells overexpressing IL-15 and IL-15 receptor alpha (IL-15Ra). CAR-T cells overexpressing IL-15 alone showed enhanced viability and superior tumor-inhibitory effects, but also resulted in serious liver injuries in tumor-free mice. However, CAR-T cells overexpressing IL-15 combined with IL-15Ra had reduced adverse effects and improved mouse survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Montano, Alondra del Carmen Ruiz-Gutierrez, Vianeth Maria del Carmen Martinez-Rodriguez, Juan Ramon Gomez-Sandoval, Juan Manuel Guzman-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velazquez
Summary: This study found that patients with periodontitis have significantly lower levels of IL-17A in plasma, but higher levels of IL-23, IL-17A, and IL-17RA in gingival tissue. Several correlations were also found, suggesting a potential role of the IL-23/IL-17A axis in the progression of periodontitis.
APPLIED SCIENCES-BASEL
(2022)
Letter
Rheumatology
Maria De Santis, Antonio Voza, Victor Savevski, Salvatore Badalamenti, Maurizio Cecconi, Alberto Mantovani, Carlo Selmi
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Paolo Corradini, Chiara Agrati, Giovanni Apolone, Alberto Mantovani, Diana Giannarelli, Vincenzo Marasco, Veronica Bordoni, Alessandra Sacchi, Giulia Matusali, Carlo Salvarani, Pier Luigi Zinzani, Renato Mantegazza, Fabrizio Tagliavini, Maria Teresa Lupo-Stanghellini, Fabio Ciceri, Silvia Damian, Antonio Uccelli, Daniela Fenoglio, Nicola Silvestris, Fausto Baldanti, Giulia Piaggio, Gennaro Ciliberto, Aldo Morrone, Franco Locatelli, Valentina Sinno, Maria Rescigno, Massimo Costantini
Summary: This study investigated the immune response to the SARS-CoV-2 vaccine in patients with tumors and immune disorders. The results showed that immunosuppressive treatment was a risk factor for a low humoral response, while the booster dose improved both humoral and T-cell responses.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Davit Pipoyan, Seda Stepanyan, Meline Beglaryan, Alberto Mantovani
Summary: This study aimed to assess the dietary exposure of the adult population in Yerevan, Armenia to nickel. Based on a total diet study and analysis, fruits, vegetables, and bread were identified as the main sources of nickel intake. The estimated chronic dietary exposure was below the safety standards for both age and gender groups, suggesting low health risks. However, acute oral exposure to nickel may pose potential health concerns for sensitized individuals.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Medicine, General & Internal
Alberto Mantovani, Cecilia Garlanda
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Endocrinology & Metabolism
Veronica Vella, Rosamaria Lappano, Eduardo Bonavita, Marcello Maggiolini, Robert Bryan Clarke, Antonino Belfiore, Ernestina Marianna De Francesco
Summary: In metabolic conditions such as obesity and diabetes, inflammation plays a dominant role, particularly in cancer. The receptor for advanced glycation end-products (RAGE) and its ligands bridge metabolism and inflammation in these conditions. This article summarizes the mechanisms of meta-inflammation in obesity- and diabetes-associated cancers, focusing on the role of RAGE and impaired insulin/insulin-like growth factor system (IIGFs) signaling. It also discusses the potential to target the RAGE pathway and its molecular connections with IIGFs to better control these types of cancers.
Editorial Material
Immunology
Diletta Di Mitri, Fabio Conforti, Alberto Mantovani
Summary: In the microenvironment of prostate bone metastasis, macrophages activate a cascade involving Activin A, the extracellular matrix, and SRC kinase, leading to resistance against anti-androgen therapy. These findings have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Jonathan Muri, Valentina Cecchinato, Andrea Cavalli, Akanksha A. A. Shanbhag, Milos Matkovic, Maira Biggiogero, Pier Andrea Maida, Jacques Moritz, Chiara Toscano, Elaheh Ghovehoud, Raffaello Furlan, Franca Barbic, Antonio Voza, Guendalina De Nadai, Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Lilly A. Murray, Gabriela Danelon-Sargenti, Simone Moro, Tao Gong, Pietro Piffaretti, Filippo Bianchini, Virginia Crivelli, Lucie Podesvova, Mattia Pedotti, David Jarrossay, Jacopo Sgrignani, Sylvia Thelen, Mario Uhr, Enos Bernasconi, Andri Rauch, Antonio Manzo, Adrian Ciurea, Marco B. L. Rocchi, Luca Varani, Bernhard Moser, Barbara Bottazzi, Marcus Thelen, Brian A. Fallon, Onur Boyman, Alberto Mantovani, Christian Garzoni, Alessandra Franzetti-Pellanda, Mariagrazia Uguccioni, Davide F. Robbiani
Summary: We found that antibodies against specific chemokines are commonly present in COVID-19 convalescents and are associated with favorable disease outcomes and a decreased risk of long COVID development at 1 year post-infection. These chemokine antibodies are also found in HIV-1 infection and autoimmune disorders, but target different chemokines compared to COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bind to the chemokine N-loop impair cell migration. Naturally occurring chemokine antibodies may modulate the inflammatory response and have therapeutic potential.
Review
Immunology
Francesca R. Mariotti, Domenico Supino, Nadine Landolina, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Summary: Interleukin-1 receptor family members (ILRs) and Toll-Like Receptors (TLRs) play a crucial role in immunity and inflammation, and are expressed by various cell types. The negative regulator IL1R8 dampens ILR and TLR signaling, while also functioning as a co-receptor for IL-37. IL-1R8 is highly expressed in NK cells, which are important for immune surveillance. This review provides an overview of IL-1R8's structure, expression, and function, with a focus on its role in regulating NK cell function in pathological conditions such as cancer and viral infections.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Damiano Chiari, Barbara Pirali, Vittoria Perano, Roberto Leone, Alberto Mantovani, Barbara Bottazzi
Summary: This article investigates the role of long pentraxin 3 (PTX3) in immune dysregulation, tissue remodeling, and oncogenesis, and finds that PTX3 may be a common factor underlying nodular thyroid disease, thyroid cancer, and autoimmune thyroid disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Elena Azzolini, Maximiliano Mollura, Chiara Pozzi, Leonardo Ubaldi, Alberto Mantovani, Carlo Selmi, Riccardo Barbieri, Maria Rescigno
Summary: An important issue often ignored is the discrepancy in medical treatment response between male and female genders. COVID-19 vaccine administration has revealed that females tend to experience more adverse events compared to males despite following identical protocols. Through logistic regression analysis of adverse events in 2385 healthcare workers receiving the Comirnaty vaccine, we found that age, sex, COVID-19 history, and BMI may contribute to the development of adverse events, particularly in young subjects, females, and individuals with a BMI below 25 kg/m(2). Furthermore, partial dependence plots indicate a 50% probability of mild adverse events lasting for a long period (>= 7 days) or any duration of severe adverse events in women below 40 years old with a BMI < 20 kg/m(2). Given that this effect is more prominent after the second vaccine dose, we propose adjusting the vaccine dosage for additional booster doses based on age, sex, and BMI to reduce adverse events without compromising vaccine efficacy.
Editorial Material
Immunology
Cecilia Garlanda, Domenico Supino
Summary: The researchers in this study designed a new drug to selectively inhibit IL-1 by analyzing an IL-1 receptor missense mutation associated with un-leashed IL-1-mediated inflammation.
Meeting Abstract
Immunology
Cecilia Garlanda, Matteo Stravalaci, Isabel Pagani, Elvezia Maria Paraboschi, Francesco Scavello, Rosanna Asselta, Elisa Vicenzi, Alberto Mantovani
Meeting Abstract
Immunology
Matteo Stravalaci, Isabel Pagani, Hang Zhong, Marina Sironi, Simone Bondesan, Federica Barzaghi, Paola Carrera, Francesca Izzo, Elena Zoia, Barbara Bottazzi, Rosanna Asselta, Giorgio Casari, Alessandro Aiuti, Alberto Mantovani, Cecilia Garlanda
Meeting Abstract
Immunology
Hang Zhong, Matteo Stravalaci, Isabel Pagani, Niloufar Kavian-Tessler, Barbara Bottazzi, Poli Guido, Elisa Vicenzi, Cecilia Garlanda
Letter
Medicine, General & Internal
Alberto Mantovani, Cecilia Garlanda
NEW ENGLAND JOURNAL OF MEDICINE
(2023)