Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Alexandra C. McQuattie-Pimentel, Ziyou Ren, Nikita Joshi, Satoshi Watanabe, Thomas Stoeger, Monica Chi, Ziyan Lu, Lango Sichizya, Raul Piseaux Aillon, Ching- Chen, Saul Soberanes, Zhangying Chen, Paul A. Reyfman, James M. Walter, Kishore R. Anekalla, Jennifer M. Davis, Kathryn A. Helmin, Constance E. Runyan, Hiam Abdala-Valencia, Kiwon Nam, Angelo Y. Meliton, Deborah R. Winter, Richard Morimoto, Gokhan M. Mutlu, Ankit Bharat, Harris Perlman, Cara J. Gottardi, Karen M. Ridge, Navdeep S. Chandel, Jacob Sznajder, William E. Balch, Benjamin D. Singer, Alexander Misharin, G. R. Scott Budinger
Summary: This study identified homogeneous age-related changes in the transcriptome of alveolar macrophages and demonstrated that the lung microenvironment affects the proliferation capacity of these cells, which in turn impacts the resistance of older patients to influenza viral infection. Targeting strategies towards the aging lung microenvironment may be necessary to restore alveolar macrophage function in aging individuals.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Oncology
Wencheng Yin, Jiaoyun Lv, Yanhong Yao, Yang Zhao, Ziyi He, Qiqi Wang, Liyan Cui, Hui Dai
Summary: Higher counts of monocytes and neutrophils in peripheral blood were observed in lung cancer patients compared to controls, especially in patients with smoking, drinking, and liver metastasis histories. Serum levels of G-CSF and GM-CSF were elevated in lung cancer patients, with G-CSF levels positively correlating with disease severity.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Pharmacology & Pharmacy
Jin-Tao Guan, Wei-Jie Wang, Du Jin, Xiao-Yue Mou, Shan-Shan Lei, Zheng-Hao Xu
Summary: This meta-analysis showed that GM-CSF antibody treatment in COVID-19 patients could reduce the risk of death and increase ventilation, without significantly increasing the risk of secondary infection or ICU admission. Older age and length of stay may have an impact on these outcomes.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Immunology
Peilin Chen, Chunyu Huang, Qing Sun, Huixian Zhong, Feng Xiong, Su Liu, Zhihong Yao, Zhiqiang Liu, Caiyun Wan, Yong Zeng, Lianghui Diao
Summary: This study investigated the concentration of GM-CSF in human single-blastocyst conditioned medium (SBCM) and its association with embryo quality and pregnancy outcome. GM-CSF was found to be a potential biomarker for predicting pregnancy outcome and selecting embryos with high developmental potential for transfer in assisted reproductive technology (ART).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jingjing Tong, Hongmin Wang, Xiang Xu, Zhihong Wan, Hongbin Fang, Jing Chen, Xiuying Mu, Zifeng Liu, Jing Chen, Haibin Su, Xiaoyan Liu, Chen Li, Xiaowen Huang, Jinhua Hu
Summary: This study aimed to verify the efficacy of G-CSF in HBV-ACLF patients and explore its effect on monocytes. The results showed that G-CSF treatment can improve the survival rate of HBV-ACLF patients by reducing the expression of M1 markers and increasing the expression of M2 markers in monocytes, promoting their reparative and anti-inflammatory functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Oncology
Lan Huang, Guisi Chen, Ying Chen, Wanwen Wu, Changli Tao, Hongwei Shao, Shulin Huang, Han Shen
Summary: Tumor immunotherapy targeting tumor-associated antigens and the impact of GM-CSF and CCL17 on tumor immunity have been widely studied. Combining survivin-specific CTL with CCL17 and GM-CSF genes can inhibit tumor growth more effectively through stable cell lines expressing these genes.
Article
Immunology
Moussa Gouife, Ziqi Ban, Xinyuan Yue, Jianhu Jiang, Jiasong Xie
Summary: This study investigated the immunomodulatory and functional properties of the goldfish MCSF-2 gene, revealing its important role in cell proliferation, differentiation, and survival. Recombinant goldfish MCSF-2 protein was successfully expressed and shown to stimulate proliferation and differentiation of leukocytes. Furthermore, rgMCSF-2 was found to modulate the expression of pro-inflammatory cytokines and transcription factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rui Chen, Yujie Li, Yangyang Zhuang, Yiming Zhang, Hailong Wu, Tao Lin, Shixuan Chen
Summary: This study combines GM-CSF and 3D nanofiber scaffolds to promote tissue regeneration. Through subcutaneous implantation in humanized mice, it was found that GM-CSF could accelerate cell migration and cytokine release, and ultimately enhance tissue regeneration. Therefore, GM-CSF loaded 3D nanofiber scaffolds have potential applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Immunology
Sherman Chu, Thomas S. McCormick, Hillard M. Lazarus, Luis O. Leal, Mahmoud A. Ghannoum
Summary: Breakthrough fungal infections can be fatal in hosts with impaired immune systems, such as those undergoing hematopoietic cell transplant or intensive chemotherapy. Risk factors include severe neutropenia and corticosteroid use. An individual's level of immunosuppression directly affects infection risk, with early intervention potentially improving outcomes.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Ayelen Ivana Pesce Viglietti, Guillermo Hernan Giambartolomei, Maria Victoria Delpino
MICROBES AND INFECTION
(2019)
Article
Immunology
Paula Constanza Arriola Benitez, Ayelen Ivan Pesce Viglietti, Marco Tulio R. Gomes, Sergio Costa Oliveira, Jorge Fabian Quarleri, Guillermo Hernan Giambartolomei, Maria Victoria Delpino
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
Lucia Zavattieri, Mariana C. Ferrero, Ivan M. Alonso Paiva, Agustina D. Sotelo, Andrea M. Canellada, Pablo C. Baldi
Article
Cell Biology
Aldana Trotta, M. Ayelen Milillo, Agustina Serafino, Luis A. Castillo, Federico Birnberg Weiss, M. Victoria Delpino, Guillermo H. Giambartolomei, Gabriela C. Fernandez, Paula Barrionuevo
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Review
Immunology
Mariana C. Ferrero, Ivan M. Alonso Paiva, Florencia Munoz Gonzalez, Pablo C. Baldi
MICROBES AND INFECTION
(2020)
Article
Endocrinology & Metabolism
A. Crivaro, C. Bondar, J. M. Mucci, M. Ormazabal, R. A. Feldman, M. V. Delpino, P. A. Rozenfeld
MOLECULAR GENETICS AND METABOLISM
(2020)
Article
Microbiology
Paula Constanza Arriola Benitez, Ayelen Ivana Pesce Viglietti, Maria Mercedes Elizalde, Guillermo Hernan Giambartolomei, Jorge Fabian Quarleri, Maria Victoria Delpino
Article
Microbiology
Ana Maria Rodriguez, Aldana Trotta, Agustina P. Melnyczajko, M. Cruz Miraglia, Kwang Sik Kim, M. Victoria Delpino, Paula Barrionuevo, Guillermo Hernan Giambartolomei
Article
Immunology
Cecilia C. Vila, Maria P. Saracino, Tomas Lombardo, Guido H. Falduto, Mariangeles Diaz, Marcela A. Calcagno, Anabel N. Pallaro, Pablo C. Baldi
Summary: This study demonstrates that a protein-deficient diet may reduce ADCC activity against newborn larvae of Trichinella spiralis in the lungs of infected rats by altering specific antibodies and effector cells.
PARASITE IMMUNOLOGY
(2021)
Letter
Immunology
Jorge Quarleri, Cintia Cevallos, M. Victoria Delpino
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Magali G. Bialer, Mariana C. Ferrero, M. Victoria Delpino, Veronica Ruiz-Ranwez, Diana M. Posadas, Pablo C. Baldi, Angeles Zorreguieta
Summary: Adhesion to host cells is essential for successful infection of bacterial pathogens. Brucella suis 1330 harbors three type Va autotransporters (BmaA, BmaB, and BmaC), all playing a role in adhesion to different cell types. These autotransporters with significant sequence similarities contribute to the adhesive properties of B. suis 1330 and display interesting variations among Brucella species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cintia Cevallos, Diego S. Ojeda, Lautaro Sanchez, Javier Urquiza, Maria Victoria Delpino, Jorge Quarleri
Summary: HIV infection can result in the death of astrocytes through cell-to-cell contact with infected cells, while the infected astrocytes can counteract this death signal and spread the contagious bystander cell death to neighboring uninfected cells.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rosa Nicole Freiberger, Cinthya Alicia Marcela Lopez, Franco Agustin Sviercz, Cintia Cevallos, Alex David Guano, Patricio Jarmoluk, Jorge Quarleri, Maria Victoria Delpino
Summary: This study explores the interaction between adipocytes and osteoblasts during Brucella abortus infection. It reveals that infected adipocytes inhibit osteoblast mineral matrix deposition, while infected osteoblasts stimulate adipocyte differentiation. This adipocyte-osteoblast crosstalk modulates mutual differentiation and contributes to bone resorption during B. abortus infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Magali G. Bialer, Gabriela Sycz, Florencia Munoz Gonzalez, Mariana C. Ferrero, Pablo C. Baldi, Angeles Zorreguieta
Review
Medicine, Research & Experimental
Maria Victoria Delpino
ACTUALIZACIONES EN OSTEOLOGIA
(2019)