Article
Cell Biology
Sae-Hae Kim, Byeol-Hee Cho, Kwang Soon Kim, Yong-Suk Jang
Summary: C5a in the Peyer's patch enhances CD8(+) T cell responses by increasing C5/C5a levels. Single-cell RNA sequencing identifies dendritic cells expressing C5aR and lysozyme as key players in CD8(+) T cell immune induction.
Article
Biochemistry & Molecular Biology
Yi Yan, Ming-Huan Jia, Zhi-Jun Le, Kang-Kang Xu, Can Li, Wen-Jia Yang
Summary: The four LsPGRP genes play important and distinct regulatory roles in the antibacterial defense response of Lasioderma serricorne, and they are significant for pest control and immune response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Genetics & Heredity
Jung-Hwa Woo, Shukho Kim, Taewon Lee, Je-Chul Lee, Ji-Hyun Shin
Summary: This study revealed that antibiotic stress can induce the production of membrane vesicles (MVs) in L. monocytogenes, and MVs produced by L. monocytogenes exposed to sub-MIC of ampicillin can trigger strong pro-inflammatory responses by inducing TNF-alpha gene expression in host cells, potentially contributing to the pathology of listeriosis.
Review
Microbiology
Jesse A. Corcoran, Brooke A. Napier
Summary: Activation of the complement pathway leads to the production of bioactive C3a, which interacts with C3aR to regulate immune cell function and bacterial infection. Recent studies have shown that various cell types can produce intracellular C3a, suggesting a need to reassess the role of C3aR in controlling bacterial infections.
Article
Gastroenterology & Hepatology
Xuan OuYang, Peng Liu, Yuling Zheng, Hua Jiang, Qingyu Lv, Wenhua Huang, Huaijie Hao, Yaya Pian, Decong Kong, Yongqiang Jiang
Summary: In this research, it was found that TRIM32 plays a crucial role in innate immune regulation during Lm infection. Trim32 deficiency significantly reduced bacteremia and proinflammatory cytokine secretion, preventing sepsis in mice with severe Lm infection. Additionally, Trim32(-/-) mice exhibited lower bacterial burden, longer survival, and reduced levels of inflammatory cytokines, along with enhanced levels of chemokines and macrophage-associated iNOS production.
Article
Immunology
Zhen-Zhen Liu, Yong-Jun Yang, Cheng-Kai Zhou, Shi-Qing Yan, Ke Ma, Yu Gao, Wei Chen
Summary: STING plays a crucial role in suppressing necroptosis to combat pulmonary S. aureus infection, with STING deficiency resulting in impaired bacterial clearance and increased cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Daniel A. Pensinger, Kimberly V. Gutierrez, Hans B. Smith, William J. B. Vincent, David S. Stevenson, Katherine A. Black, Krizia M. Perez-Medina, Joseph P. Dillard, Kyu Y. Rhee, Daniel Amador-Noguez, TuAnh N. Huynh, John-Demian Sauer
Summary: Bacterial pathogens, such as Listeria monocytogenes, need to adapt to the host cytosol environment in order to survive and cause disease. GlmR, a protein of unknown function, is essential for the survival and virulence of Listeria monocytogenes. Understanding the role of GlmR and how cytosolic pathogens adapt and survive is crucial for developing new treatments.
Article
Immunology
Rita Pombinho, Jorge Pinheiro, Mariana Resende, Diana Meireles, Sirpa Jalkanen, Sandra Sousa, Didier Cabanes
Summary: STAB-1 plays a regulatory role in the immune response and bacterial clearance during Lm infection, as well as in modulating bacterial uptake by macrophages.
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Immunology
Yong Hun Jo, Jung Hee Lee, Bharat Bhusan Patnaik, Maryam Keshavarz, Yong Seok Lee, Yeon Soo Han
Summary: The yellow mealworm beetle has been used as an experimental model to study immune defenses against parasites and pathogens. The activation of hemocoelic defenses relies on pattern recognition receptors and signaling cascades such as NF-kappa B. Studies have also shown a cross-talk between autophagy and the innate immune system in response to infections by gram-positive bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Lei Sun, Gil Rogiers, Pascal Courtin, Marie-Pierre Chapot-Chartier, Helene Bierne, Chris W. Michiels
Summary: AsnB of L. monocytogenes plays a role in mediating the amidation of mDAP residues in peptidoglycan, affecting various cell wall and cell surface-related properties as well as bacterial virulence. This study highlights the importance of amidation of peptidoglycan mDAP residues in cell wall anchoring of invasion proteins and its implications for virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Rebecca Stearns, Kristen Matak, Annette Freshour, Cangliang Shen
Summary: This study compared different methods to reduce and prevent cross-contamination of Listeria monocytogenes and L. innocua on Fuji apples. The results showed that using a dip procedure with 0.25 ml/dL H2O2-PAA was the most effective in reducing the contamination for both L. monocytogenes and L. innocua. Additionally, using a low pressure, conventional, hand-held garden sprayer with 0.25 ml/dL H2O2-PAA minimized the cross-contamination rate. The study also found that L. innocua is a suitable surrogate for L. monocytogenes on apples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Immunology
Sarah Frentzel, Andreas Jeron, Alexander Pausder, Olivia Kershaw, Julia Volckmar, Ingo Schmitz, Dunja Bruder
Summary: I kappa B proteins play a crucial role in regulating the activation and inhibition of NF-kappa B transcription factor complexes. In this study, it was found that the absence of I kappa B-NS resulted in a transcriptional repression of immune responses, particularly in myeloid cells. Further investigation revealed that the blunted inflammatory response of monocytes in I kappa B-NS-deficient mice contributed to their resistance against Lm infection and reduced immunopathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Zhaolun Li, Hongyan Wu, Jianan Liu, Hongshun Hao, Jingran Bi, Hongman Hou, Gongliang Zhang
Summary: This study investigates the synergistic effects of benzyl isothiocyanate (BITC) and resveratrol (RS) on Listeria monocytogenes and their potential application in chicken meat preservation. The combination of BITC and RS significantly enhances antimicrobial activity and inhibits the growth of Listeria monocytogenes in a short time period. It also disrupts biofilm formation and induces intracellular ROS surges. The study suggests that the combination of BITC and RS could be a promising strategy for food preservation.
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Krisana Asano, Sayuri Yoshimura, Akio Nakane
INFECTION AND IMMUNITY
(2015)
Article
Immunology
Kouji Narita, Dong-Liang Hu, Krisana Asano, Akio Nakane
PATHOGENS AND DISEASE
(2015)
Article
Biotechnology & Applied Microbiology
S. Hirose, H. K. Ono, K. Omoe, D-L. Hu, K. Asano, Y. Yamamoto, A. Nakane
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Multidisciplinary Sciences
Krisana Asano, Hiroshi Sashinami, Arihiro Osanai, Shouhei Hirose, Hisaya K. Ono, Kouji Narita, Dong-Liang Hu, Akio Nakane
SCIENTIFIC REPORTS
(2016)
Article
Biotechnology & Applied Microbiology
D. -L. Hu, H. K. Ono, S. Isayama, R. Okada, M. Okamura, L. C. Lei, Z. S. Liu, X. -C. Zhang, M. Y. Liu, J. C. Cui, A. Nakane
JOURNAL OF APPLIED MICROBIOLOGY
(2017)
Article
Immunology
Kouji Narita, Krisana Asano, Akio Nakane
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2017)
Article
Immunology
Hisaya K. Ono, Shouhei Hirose, Ikunori Naito, Yusuke Sato'o, Krisana Asano, Dong-Liang Hu, Katsuhiko Omoe, Akio Nakane
MICROBIOLOGY AND IMMUNOLOGY
(2017)
Article
Cell & Tissue Engineering
T. Itabashi, K. Narita, A. Ono, K. Wada, T. Tanaka, G. Kumagai, R. Yamauchi, A. Nakane, Y. Ishibashi
BONE & JOINT RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Kouji Narita, Krisana Asano, Yukihiro Morimoto, Tatsushi Igarashi, Michael R. Hamblin, Tianhong Dai, Akio Nakane
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2018)
Article
Immunology
Krisana Asano, Kouji Narita, Shouhei Hirose, Akio Nakane
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Hiroto Hiraga, Daisuke Chinda, Takato Maeda, Yasuhisa Murai, Kohei Ogasawara, Ryutaro Muramoto, Shinji Ota, Keisuke Hasui, Hirotake Sakuraba, Yoh Ishiguro, Shukuko Yoshida, Krisana Asano, Akio Nakane, Shinsaku Fukuda
Summary: Vitamin A plays a crucial role in maintaining intestinal homeostasis and the function of acquired immunity and epithelial barriers. However, its involvement in innate immunity has been mostly unknown. This study found that vitamin A deficiency leads to more severe dextran sulfate sodium (DSS)-induced colitis and elevated inflammation in mice. It was also observed that vitamin A is essential for the efficient fusion of autophagosomes with lysosomes in colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shouhei Hirose, Kouji Narita, Krisana Asano, Akio Nakane
Article
Medicine, Research & Experimental
Krisana Asano, Emiko Takahashi, Sayuri Yoshimura, Akio Nakane
BIOMEDICAL REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Masahiro Sano, Yi Shang, Akio Nakane, Tomoaki Saito
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Shouhei Hirose, Krisana Asano, Akio Nakane
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)