Article
Microbiology
Sukumar Pal, Sydni Sheff, Mufadhal Al-Kuhlani, David M. Ojcius, Luis M. de la Maza
Summary: TRAIL-R does not appear to play a major role in the susceptibility, clinical outcomes, or long-term sequelae of C. muridarum infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Nina Dieu Nhien Tran Nguyen, Safia Guleed, Anja Weinreich Olsen, Frank Follmann, Jan Pravsgaard Christensen, Jes Dietrich
Summary: This study found that enhancing tissue-resident Th1/Th17 T cell immunity in the genital tract can improve protection against Chlamydia trachomatis infections, with a combined vaccine strategy potentially more effective than a single approach.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hui Chen, Bo Peng, Chunfen Yang, Lijuan Xie, Shufang Zhong, Zhenjie Sun, Zhongyu Li, Chuan Wang, Xiao Liu, Xin Tang, Guangming Zhong, Chunxue Lu
Summary: The study on Chlamydia trachomatis vaccine shows that mutant CPAF vaccine is equally effective as wild type, significantly reducing infection and reproductive tract pathology in mice. The protection relies on CD4+ T cells, indicating the potential development of CPAF as a clinical chlamydial vaccine.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Delia Onorini, Cory Ann Leonard, Regenia Phillips Campbell, Barbara Praehauser, Theresa Pesch, Robert V. Schoborg, Ann E. Jerse, Bernadetta Tarigan, Nicole Borel
Summary: Chlamydia trachomatis and Neisseria gonorrhoeae are commonly reported bacterial sexually transmitted disease agents. However, the co-infection of C. trachomatis and N. gonorrhoeae is not well studied. This study aimed to investigate the reactivation of latent C. muridarum infection with N. gonorrhoeae in mice. The results showed that N. gonorrhoeae did not reactivate latent C. muridarum shedding, suggesting that the interaction between C. trachomatis and N. gonorrhoeae may depend on actively replicating C. trachomatis in the genital tract.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Rajnish Sahu, Saurabh Dixit, Richa Verma, Skyla A. Duncan, Lula Smith, Guillermo H. Giambartolomei, Shree R. Singh, Vida A. Dennis
Summary: The PLGA-rMOMP nanovaccine demonstrated protective efficacy in mice against genital Chlamydia challenges by enhancing immune responses and inducing specific Th1 cytokines, antibodies, and T-cell phenotypes. The vaccine also showed potential for developing a nano-based Chlamydia vaccine by triggering cellular and humoral immune effectors through extended-releasing PLGA encapsulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wenjing Xiang, Nanyan Yu, Aihua Lei, Xiaofang Li, Shui Tan, Lijun Huang, Zhou Zhou
Summary: Chlamydial infection causes clinically relevant diseases and significant morbidity in humans. Immune and inflammatory responses play crucial roles in both clearing the infection and causing pathology in host tissues. Cytokines produced in response to Chlamydia infection can regulate immune responses, but excessive production can lead to overreactive inflammation, affecting host and Chlamydia metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Arlo Randall, Andy Teng, Xiaowu Liang, Sukumar Pal, Alice F. Tarantal, Joseph Fike, Peter A. Barry, Luis M. de la Maza
Summary: The study identified eight immunodominant antigens that can be used to detect primary C. trachomatis genital infections and design vaccine strategies.
Article
Public, Environmental & Occupational Health
Ting Li, Zhaohui Liu, Dai Zhang, Qinping Liao, Shangrong Fan, Min Hao, Ying Hong, Xiufeng Huang, Huilan Wang, Zhengai Xiong, Hong Xu, Fengxia Xue, Min Xue, Xingsheng Yang, Jianqing Zhang
Summary: This study examined the prevalence of genital chlamydia and associated risk factors in Chinese female outpatients with genital tract infections. The results showed that the prevalence rate of chlamydia was 6.33% and the prevalence rate of gonococcal infection was 0.01%. Risk factors for chlamydia included premarital sex behavior, first sexual intercourse before the age of 20, and bacterial vaginosis.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Ryota Itoh, Yusuke Kurihara, Michinobu Yoshimura, Kenji Hiromatsu
Summary: This study found that anticancer drugs, bortezomib and ixazomib, have strong inhibitory activity against Chlamydia, a parasitic intracellular bacterium that causes various infectious diseases. These drugs selectively eliminate Chlamydia-infected cells and show potential for treating chlamydial infections, including persistent infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Rico Jahnke, Svea Matthiesen, Luca M. Zaeck, Stefan Finke, Michael R. Knittler
Summary: Tunneling nanotubes (TNTs) are dynamic cellular connections that play an important role in cell-to-cell communication and the transfer of molecules and organelles. In this study, we demonstrate that chlamydia-infected cells can form TNT-like structures, through which the intracellular reticulate bodies (RBs) of chlamydia can pass into neighboring uninfected cells. These findings suggest that TNTs play a critical role in the direct cell-to-cell transmission of chlamydia.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Uma M. Nagarajan, Crescentia Cho, Clare E. Gyorke, Shanmugam Nagarajan, J. Ashley Ezzell, Hayden Brochu, Ian Huntress, Erin Harrell, Xinxia Peng
Summary: This study found that TNF alpha can enhance the expression and release of IL-1 alpha in infected epithelial cells, leading to cell death and hyperinflammatory response, resulting in tissue damage in the oviducts during chlamydial infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Editorial Material
Immunology
Philippe Krebs, Hui Peng, Vikas Duhan
Summary: Natural killer (NK) cells are innate immune cells that can recognize and kill virus-infected cells and cancer cells. NK cells have diverse subsets based on their expression of various receptors and factors, and their plasticity during virus infection can impact their phenotypic and functional diversity. This Research Topic presents and discusses the latest research on NK cell plasticity and diversity in viral infections, as well as its therapeutic implications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ning Ning, Rongxing Weng, Chunlai Zhang, Lizhang Wen, Honglin Wang, Jianbin Ye, Jing Li, Xiangsheng Chen, Yumao Cai
Summary: This study aimed to cluster the symptoms associated with Neisseria gonorrhoeae and Chlamydia trachomatis and identify the clusters associated with a higher risk of infection. The results suggest a new strategy of symptomatic management for sexually transmitted infections and may help healthcare providers in identifying and providing care for high-risk patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Miguel A. B. Mercado, Wuying Du, Priyangi A. Malaviarachchi, Jessica Gann, Lin-Xi Li
Summary: The study revealed that innate IFN-gamma is crucial for preventing systemic dissemination of Chlamydia, while IFN-gamma produced by CD4 T cells is largely redundant at the FRT mucosa.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Nadejda Beliakova-Bethell, Kathirvel Maruthai, Ruijie Xu, Liliana C. M. Salvador, Ankita Garg
Summary: The study shows that long after recovery from CoV2 infection, M-MDSC suppresses immune responses to CoV2 antigens. This finding suggests that M-MDSC may serve as novel regulators of CoV2-specific T cell responses and should be targeted to enhance vaccine responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
James Reinecke, Stefanie Lowas, Jessica Snowden, Kari Neemann
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2019)
Article
Pediatrics
Lauren C. Frazer, Amy E. O'Connell
Summary: This study retrospectively reviewed the records of infants who underwent immunologic testing in an NICU from 2006 to 2018, finding that the proportion of PID testing increased significantly in premature infants. Term and late preterm infants, as well as EP infants, who had immune testing, mostly had genetic diagnoses associated with immunodeficiency. Extremely premature infants showed persistent immune derangements through term postmenstrual age.
PEDIATRIC RESEARCH
(2021)
Review
Pediatrics
Brian P. O'Sullivan, Laura James, Joseph M. Majure, Scott Bickel, Ly-Thao Phan, Monica Serrano Gonzalez, Heather Staples, Jade Tam-Williams, Jason Lang, Jessica Snowden
Summary: Excess adipose tissue can lead to an enhanced inflammatory state and worsen the pathogenesis and severity of asthma. Vitamin D, known for its anti-inflammatory properties, is often found to be low in children with asthma and obesity. Supplementation with vitamin D has been proposed as a simple, safe, and inexpensive adjunctive therapy, but research on its pharmacokinetics and therapeutic potential in children with obesity-related asthma is limited.
PEDIATRIC PULMONOLOGY
(2021)
Review
Obstetrics & Gynecology
Alejandra Barrero-Castillero, Kristyn S. Beam, Laura B. Bernardini, Erika G. Cordova Ramos, Patricia E. Davenport, Anna R. Duncan, Yarden S. Fraiman, Lauren C. Frazer, Helen Healy, Emily M. Herzberg, Madeline L. Keyes, Kristen T. Leeman, Kristin Leone, Jonathan C. Levin, Matthew Lin, Ravikiran M. Raju, Anne Sullivan
Summary: This review provides a comprehensive overview of neonatal-perinatal perspectives of COVID-19, ranging from the basic science of infection and recommendations for care of pregnant women and neonates to important psychosocial, ethical, and racial/ethnic topics emerging as a result of both the pandemic and the response of the healthcare community to the care of infected individuals.
JOURNAL OF PERINATOLOGY
(2021)
Review
Pediatrics
Lauren C. Frazer, Camilia R. Martin
Summary: Parenteral lipid emulsions are essential for the nutrition of extremely low gestational age newborns until enteral intake is established. Different types of lipid emulsions can meet fat and energy requirements, but the choice must consider metabolic differences and potential health risks.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Article
Immunology
Joshua L. Kennedy, J. Craig Forrest, Sean G. Young, Benjamin Amick, Mark Williams, Laura James, Jessica Snowden, Victor M. Cardenas, Danielle Boothe, Catherine Kirkpatrick, Zeel Modi, Katherine Caid, Shana Owens, Marianne Kouassi, Ryan Mann, Claire Putt, Katherine Irish-Clardy, Michael Macechko, Ronald K. Brimberry, Wendy N. Nembhard, Pearl A. McElfish, Ruofei Du, Jing Jin, Namvar Zohoori, Atul Kothari, Hoda Hagrass, Ericka Olgaard, Karl W. Boehme
Summary: This study aimed to estimate the infection rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the small rural state of Arkansas by using SARS-CoV-2 antibody prevalence as an indicator. The study found that the SARS-CoV-2 seroprevalence in Arkansas steadily increased from 2.6% in August to 7.4% in December 2020. There was no significant difference in seroprevalence between rural and urban areas. However, Hispanics and Blacks had higher seroprevalence rates compared to Whites in all time periods.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Lauren C. Frazer, William Yakah, Camilia R. Martin
Summary: This study found a correlation between lower levels of acetic acid in the stool of preterm infants and increased risk of bronchopulmonary disease.
Article
Pediatrics
Bobby L. Boyanton, Jessica N. Snowden, Rachel A. Frenner, Eric R. Rosenbaum, Heather L. Young, Joshua L. Kennedy
CLINICAL PEDIATRICS
(2023)
Review
Immunology
Lauren C. Frazer, Misty Good
Summary: Rapid development of the fetal and neonatal intestine is necessary for growth and protection. In utero, the fetus receives nutrition and is protected, allowing the intestine to develop in a quiescent environment. After birth, the intestine needs to provide defense and nutrition, which is achieved through the development of specialized epithelial cells from intestinal stem cells. Interrupting these homeostatic processes can lead to intestinal diseases, such as necrotizing enterocolitis.
MUCOSAL IMMUNOLOGY
(2022)
Article
Infectious Diseases
Matthew P. Kronman, Jessica N. Snowden
Summary: COVID-19 outbreak has revealed the disproportionate impact of infectious diseases on vulnerable communities, which is not solely determined by biological susceptibility but also influenced by socioeconomic factors and other social determinants of health.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Medicine, Research & Experimental
James R. Roberts, Sheva K. Chervinskiy, Russell McCulloh, Jessica Snowden, Paul M. Darden, Thao-Ly T. Phan, Erin Dawley, Victoria Reynolds, Crystal S. Lim, Lee Pyles, DeAnn Hubberd, Jaime Baldner, Lora Lawrence, Ann M. Davis
Summary: This paper outlines the methods used to complete a pediatric obesity treatment trial using virtual procedures during the COVID-19 pandemic. Virtual procedures enhanced the ability to establish relationships with previously unreachable participants, but also presented challenges.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Infectious Diseases
Maheswari Ekambaram, Aleisha Nabower, Prabi Rajbhandari, Jaclyn Eisenberg, Nathaniel Goodrich, Krow Ampofo, Nathan S. Gollehon, Kimberly C. Martin, Elizabeth Lyden, Jessica Snowden
Summary: Discordant results between FilmArray Meningitis/Encephalitis panel (MEP) and conventional testing are common in children, which presents a diagnostic challenge. More than half of the bacterial pathogens identified by MEP did not have a corresponding positive cerebrospinal fluid culture. Treatment decisions based on a positive MEP should be made in the appropriate clinical context.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Pediatrics
Angela N. Lewis, Diomel de la Cruz, James L. Wynn, Lauren C. Frazer, William Yakah, Camilia R. Martin, Heeju Yang, Elena Itriago, Jana Unger, Amy B. Hair, Jessica Miele, Brynne A. Sullivan, Ameena Husain, Misty Good
Summary: The nSOFA score can effectively distinguish mortality and surgery or death risks in infants with NEC, and it can improve the classification of organ dysfunction in NEC infants.
Article
Infectious Diseases
Karl W. Boehme, Joshua L. Kennedy, Jessica Snowden, Shana M. Owens, Marianne Kouassi, Ryan L. Mann, Amairani Paredes, Claire Putt, Laura James, Jing Jin, Ruofei Du, Catherine Kirkpatrick, Zeel Modi, Katherine Caid, Sean Young, Namvar Zohoori, Atul Kothari, Bobby L. Boyanton, J. Craig Forrest
Summary: This study investigated the seroprevalence of SARS-CoV-2 antibodies in children and adolescents in Arkansas during the first year of the COVID-19 pandemic. The results showed that by spring 2021, most children were not infected with SARS-CoV-2, but Hispanic and black children had a higher seroprevalence rate.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Pediatrics
Jessica Snowden, Anjali Patwardhan
Summary: This study describes a cohort of 989 children with laboratory-confirmed SARS-CoV-2 infection in the U.S., with the majority of children being asymptomatic, especially those over the age of 2. However, older children are more likely to develop severe illness when symptoms do appear, while Hispanic children are more likely to exhibit symptoms at diagnosis, emphasizing the importance of cultural outreach to vulnerable communities.
GLOBAL PEDIATRIC HEALTH
(2021)