Article
Chemistry, Medicinal
Katsushiro Miyamoto, Hiroaki Kawano, Naoko Okai, Takeshi Hiromoto, Nao Miyano, Koji Tomoo, Takahiro Tsuchiya, Jun Komano, Tomotaka Tanabe, Tatsuya Funahashi, Hiroshi Tsujibo
Summary: Vibrio vulnificus M2799 secretes the catecholate siderophore vulnibactin to capture ferric ions for growth, utilizing a ferric-import system composed of various proteins including an isochorismate synthase and an outer membrane receptor. In infectious diseases, periplasmic-binding proteins and ferric-chelate reductases involved in the ferric-siderophore utilization system could be potential targets for drug discovery.
Article
Biotechnology & Applied Microbiology
You-Chul Jung, Mi-Ae Lee, Han-Shin Kim, Kyu-Ho Lee
Summary: The formation of Vibrio vulnificus biofilms involves a complex process where the production and stability of flagellin proteins are controlled by DegQ and FlaJ at different stages, affecting the development of biofilms.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Microbiology
Xinning Liu, Yuanchang Liu, Guangjian Zhao, Yidan Zhang, Lu Liu, Juan Wang, Yifan Wang, Siyu Zhang, Xin Li, Dongliang Guo, Peng Wang, Ximing Xu
Summary: This study investigated the impact of NAT from Vibrio vulnificus on acetyl group transformation in arylamine antibiotics, focusing on its structure, enzyme activity, and stability, revealing its activity under different conditions and sensitivity to metal ions. Additionally, kinetic parameters and structural analysis showed that (VIBVN)NAT could acetylate various aromatic amine substrates and contribute to arylamine antibiotic resistance in Vibrio vulnificus.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Polymer Science
Sreejita Ghosh, Dibyajit Lahiri, Moupriya Nag, Ankita Dey, Tanmay Sarkar, Sushil Kumar Pathak, Hisham Atan Edinur, Siddhartha Pati, Rina Rani Ray
Summary: Bacteria are major cell factories that can convert nitrogen and carbon sources into various biopolymers, with important medicinal applications and roles in pathogenicity.
Article
Immunology
Xian-Hui Huang, Yao Ma, Han Lou, Na Chen, Ting Zhang, Liu-Ying Wu, Yi-Ju Chen, Meng-Meng Zheng, Yong-Liang Lou, Dan-Li Xie
Summary: The TSC1-mTOR signaling pathway plays a crucial role in regulating the innate immunity against V. vulnificus infection, with TSC1 deficiency leading to enhanced M1 response and impaired bactericidal activity in macrophages. Inhibition of mTOR activity can reverse the hypersensitive M1 response induced by V. vulnificus infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hye-Jin Kim, You-Tae Kim, Hyeun Bum Kim, Sang Ho Choi, Ju-Hoon Lee
Summary: The bacteriophage VVP001 was identified as a potential natural food preservative and biocontrol agent against V. vulnificus, with stability at a wide range of temperatures and pH levels suitable for food applications. In vitro studies showed VVP001 effectively inhibited the growth of V. vulnificus, and genome analysis indicated the absence of genes encoding toxins or virulence factors essential for food safety. Application of VVP001 to contaminated abalone samples and in vivo mouse survival tests further demonstrated its ability to protect against high mortality rates.
Article
Food Science & Technology
Kunyao Luo, Pengyu Zhao, Yifei He, Shengnan Kang, Chenyu Shen, Shuo Wang, Meixian Guo, Lehui Wang, Chao Shi
Summary: This study found that oregano essential oil (OEO) has inhibitory and germicidal effects on Vibrio vulnificus, a pathogenic bacteria commonly found in seafood. The OEO works by generating reactive oxygen species (ROS) that cause membrane damage in the bacteria, reducing their permeability and integrity. No DNA damage was observed at the tested concentration of OEO. Additionally, OEO effectively killed V. vulnificus in oysters. Overall, OEO shows promise in controlling V. vulnificus contamination in seafood.
Article
Immunology
Keri A. Lydon, Thomas Kinsey, Chinh Le, Paul A. Gulig, Jessica L. Jones
Summary: This study analyzed the biochemical profiles and virulence genotypes of Vibrio vulnificus isolates from clinical and oyster sources. While there were differences between the isolates, there was not a significant correlation between biochemical profiles and genotype with virulence potential, as determined by a mouse model. Results from the mouse model indicated a potential for human infection, with some strains showing a correlation with seasonality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tim Downing, Min Jie Lee, Conor Archbold, Adam McDonnell, Alexander Rahm
Summary: The study highlights the importance of compatibility between plasmids and new host cells in the spread of antimicrobial resistance and virulence genes. Computational analysis of protein-protein interactions suggests that an excess rate of PPIs may be an indicator of host-plasmid compatibility.
Article
Microbiology
Hye-Young Kim, MubarakAli Davoodbasha, Jung-Wan Kim
Summary: Glycogen plays an important role in the survival and metabolism regulation of V. vulnificus. The malZ gene of V. vulnificus is involved in glycogen metabolism through hydrolyzing maltodextrin to glucose and maltose. Additionally, MalZ promotes cellulose synthesis in the presence of excessive maltose, while growth and glycogen accumulation decrease in a medium containing maltodextrin. The study suggests that V. vulnificus has diverse pathways for glycogen metabolism depending on the carbon source.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Microbiology
Jeong-A Kim, Bo-Ram Jang, Yu-Ra Kim, You-Chul Jung, Kun-Soo Kim, Kyu-Ho Lee
Summary: This study found that V. vulnificus modulates the gut commensal community structure by promoting the production of cyclo-Phe-Pro (cFP), which lowers the levels of Bacteroides vulgatus and increases its pathogenicity in hosts.
Article
Biology
Veronika Heinz, Wenke Jaeckel, Susann Kaltwasser, Laura Cutugno, Patricia Bedrunka, Anica Graf, Alexander Reder, Stephan Michalik, Vishnu M. Dhople, M. Gregor Madej, Maria Conway, Marcus Lechner, Katharina Riedel, Gert Bange, Aoife Boyd, Uwe Voelker, Richard J. Lewis, Jon Marles-Wright, Christine Ziegler, Jan Pane-Farre
Summary: A cryo-electron microscopy reconstruction revealed variations in subunit composition and symmetry in the stressosome complex of Vibrio vulnificus, a Gram-negative bacterium. The stressosome senses oxygen and is involved in modulating iron metabolism.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Quanxin Gao, Shaokui Yi, Yang Li, Jinping Luo, Qianqian Xing, Xia Yang, Ming Zhao, Minghua Min, Qian Wang, Yabing Wang, Lingbo Ma, Shiming Peng
Summary: The study demonstrates that Vibrio anguillarum flagellins have significant effects on cell apoptosis, TLR5 expression, and production of inflammatory cytokines. FlaB in particular exhibits strong immunostimulation effects, significantly affecting TLR5 and inflammatory cytokine expression in infection. However, in vivo studies show no significant differences between groups, indicating the need for further research to understand the underlying mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Dan Wang, Haoran Wang
Summary: This study investigates the characteristics of fibrillar adhesins in Vibrio parahaemolyticus and their potential applications in bacterial interaction and disease prevention.
Article
Microbiology
Ah-Reum Han, Haeyoung Kim, Jong-Tae Park, Jung-Wan Kim
Summary: A study found that the vvde1 gene in Vibrio vulnificus MO6-24/O encodes a debranching enzyme, which has higher activity at low temperatures and efficiently hydrolyzes glycogen and pullulan. The vvde1 mutant accumulates more glycogen in the medium and has a slightly different side chain length distribution of glycogen compared to the wild type, which may be related to the virulence of the pathogen.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Microbiology
Juri Kim, Soon-Jung Park
Article
Parasitology
Eun-Ah Park, Ik-Hwan Hang, Jung-Hyun Kim, Soon-Jung Park, Jae-Sook Ryu, Myoung-Hee Ahn
KOREAN JOURNAL OF PARASITOLOGY
(2019)
Article
Parasitology
Juri Kim, Mee Young Shin, Soon-Jung Park
KOREAN JOURNAL OF PARASITOLOGY
(2019)
Article
Parasitology
Juri Kim, Soon-Jung Park
PARASITES & VECTORS
(2019)
Article
Parasitology
Hye-Yeon Lee, Eun-Ah Park, Kyung-Jo Lee, Kyu-Ho Lee, Soon-Jung Park
KOREAN JOURNAL OF PARASITOLOGY
(2019)
Article
Parasitology
Juri Kim, Mee Young Shin, Soon-Jung Park
KOREAN JOURNAL OF PARASITOLOGY
(2020)
Article
Parasitology
Eun-Ah Park, Juri Kim, Mee Young Shin, Soon-Jung Park
Summary: The study reveals the role of GlPLK in Giardia cell division, especially during cytokinesis, and its involvement in flagella formation.
PARASITES & VECTORS
(2021)
Article
Parasitology
Eun-Ah Park, Juri Kim, Mee Young Shin, Soon-Jung Park
Summary: There is an interaction between GlKin-13 and GlPLK, with GlPLK modulating the microtubule depolymerizing activity of GlKin-13 to influence flagellar and median body formation.
KOREAN JOURNAL OF PARASITOLOGY
(2022)
Article
Parasitology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study confirms the transcriptional activation function of GlMyb2 during encystation in Giardia lamblia. Through chromatin immunoprecipitation experiments and quantitative real-time PCR, several target genes of GlMyb2 were identified, with a detailed analysis on the promoter region of glcwp1 gene.
PARASITES & VECTORS
(2022)