Article
Immunology
Abby L. Adams, Karen Eberle, Jonothan Rosario Colon, Evan Courville, Hong Xin
Summary: The study developed a double-peptide construct vaccine that significantly enhanced survival against C. albicans challenge in mice by targeting surface proteins. The research showed that Fba and Met6 specific antibodies promoted the immunoglobulin effect, while complement played an important role in the vaccine's protection against C. albicans infection.
Article
Orthopedics
Yu Wang, Dustin Dikeman, Jeffrey Zhang, Nicole Ackerman, Sophia Kim, Martin P. Alphonse, Roger Ortines, Haiyun Liu, Daniel P. Joyce, Carly A. Dillen, John M. Thompson, Abigail A. Thomas, Roger D. Plaut, Lloyd S. Miller, Nathan K. Archer
Summary: CCR2 plays a crucial role in host defense during orthopedic implant-associated infections, by increasing immune cell infiltrates in the draining lymph nodes to contain and prevent the spread of infection.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Biology
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao
Summary: Using single-cell sequencing, researchers identified a specific subpopulation of megakaryocytes (MKs) that highly expressed CXCR4 and exhibited both immune characteristics and MK-specific features. These CXCR4(high) MKs interacted with myeloid cells to promote their migration and enhance bacterial phagocytosis, and they were also capable of antigen presentation to activate T cells. Furthermore, in response to bacterial infection, these CXCR4(high) MKs could exit circulation and infiltrate into the spleen, liver, and lung. The ablation of MKs suppressed the innate immune response and impaired the anti-bacterial effects of T cells in mice.
Article
Microbiology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Sabah Haq, Daniel N. Villageliu, Christi M. Ellis, Niaz Bahar Chowdhury, Amanda E. Ramer-Tait, Jeffrey D. Price, Daren L. Knoell
Summary: Intestinal dysbiosis increases susceptibility to infection due to metabolic profile changes, resulting in increased morbidity. The study found that ZIP8, a type of zinc transporter, is important for myeloid cells in maintaining host defense against bacterial pneumonia. Furthermore, a common variant of ZIP8 is closely associated with inflammation-based disorders and bacterial infection. The researchers developed a new model to study the effects of ZIP8-mediated intestinal dysbiosis on pulmonary host defense, independent of genetic factors. The results showed that the intestinal microbiota, regardless of host genetics, play a crucial role in regulating host defense in the lung against infection. These findings support future microbiome-based intervention studies, considering the high prevalence of zinc deficiency and the rs13107325 allele in humans.
Article
Medicine, General & Internal
Yanxia Chen, Wenchen Song, Can Li, Jiaxuan Wang, Feifei Liu, Zhanhong Ye, Peidi Ren, Yihan Tong, Junhua Li, Zhihua Ou, Andrew Chak-Yiu Lee, Jian-Piao Cai, Bosco Ho-Yin Wong, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, AnnaJin-Xia Zhang, Hin Chu
Summary: Obesity is a risk factor for severe manifestations of COVID-19, and this study investigated the effects of COVID-19 mRNA vaccination on immune responses and reinfection in obese mice. The findings showed impaired adaptive immune responses to COVID-19 infection and vaccination in obese mice, leading to higher susceptibility to reinfection and lower vaccine efficacy. However, vaccinated obese mice were still protected from lung damage during reinfection and showed increased production of interferons. This suggests that COVID-19 mRNA vaccination enhances innate antiviral responses in obesity when adaptive immunity is suboptimal.
Article
Immunology
Daniel A. Powell, Amy P. Hsu, Christine D. Butkiewicz, Hien T. Trinh, Jeffrey A. Frelinger, Steven M. Holland, John N. Galgiani, Lisa F. Shubitz
Summary: This study investigates the use of vaccination in mice with immune deficiencies to mitigate disseminated coccidioidomycosis (DCM). The results show that vaccinated mice had significantly reduced fungal burdens in the lungs and spleen, and controlled spleen dissemination. These findings suggest that the Delta cps1 vaccine could be beneficial for individuals at high risk of immune deficiencies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luz Marina Sanchez-Mendoza, Carlos Perez-Sanchez, Sandra Rodriguez-Lopez, Chary Lopez-Pedrera, Miguel Calvo-Rubio, Rafael de Cabo, Maria I. Buron, Jose A. Gonzalez-Reyes, Jose M. Villalba
Summary: The study investigates the effect of sex on metabolic adaptations induced by overexpression of CYB5R3 and the modulation of key markers related to mitochondrial function in skeletal muscle. It was found that CYB5R3 overexpression leads to enhanced mitochondrial biogenesis and function, as well as increased mitochondrial abundance in skeletal muscle. These beneficial actions are predominantly observed in females, with differences in NADH levels and the abundance of cytochrome c and DRP-1. The results also show ultrastructural changes in transgenic females, including an increase in the number and size of mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell
Summary: Pneumococcal pneumonia is a major cause of disease and death worldwide, with compromised immune function and an insufficient dietary intake of zinc increasing the risk. This study reveals the critical role of the zinc transporter ZIP8 in host defense and the adverse impact of a common defective ZIP8 allele on the gut microbiota essential for lung immunity. Loss of ZIP8 function leads to intestinal dysbiosis and impaired host defense in the lung, highlighting the need for further investigation and improved surveillance and treatment strategies given the high incidence of dietary zinc deficiency and the ZIP8 variant allele in the human population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Young Jae Kim, June-Young Lee, Jae Jin Lee, Sang Min Jeon, Prashanta Silwal, In Soo Kim, Hyeon Ji Kim, Cho Rong Park, Chaeuk Chung, Jeong Eun Han, Jee-Won Choi, Euon Jung Tak, Ji-Ho Yoo, Su-Won Jeong, Do-Yeon Kim, Warisa Ketphan, Su-Young Kim, Byung Woo Jhun, Jake Whang, Jin-Man Kim, Hyungjin Eoh, Jin-Woo Bae, Eun-Kyeong Jo
Summary: The study demonstrates that l-arginine enhances pulmonary immune defense against nontuberculous mycobacterial pulmonary diseases (NTM-PD) by influencing the gut-lung axis, increasing the number of IFN-gamma-producing effector T cells and M1 macrophages in the lungs, and enhancing antimicrobial activity.
Article
Immunology
Orlando E. Flores-Maldonado, Gloria M. Gonzalez, Angel Andrade-Torres, Rogelio Trevino-Rangel, Luis Donis-Maturano, Aaron Silva-Sanchez, Romel Hernandez-Bello, Alexandra Montoya, Rosario Salazar-Riojas, Carolina Romo-Gonzalez, Miguel A. Becerril-Garcia
Summary: In this study, a new neonatal murine model of intravenous Candida albicans infection was developed using 0-days-old mice. It was found that newborn mice infected with a low inoculum of Candida albicans can survive, but an increase in inoculum rapidly becomes lethal due to massive fungal invasion and exacerbated CD45(+) leukocyte infiltrate and cytokine production. Overall, Candida albicans infection in newborn mice mainly affects the brain and liver.
MICROBIAL PATHOGENESIS
(2021)
Article
Multidisciplinary Sciences
Orlando Laitano, Gerard P. Robinson, Kevin O. Murray, Christian K. Garcia, Alex J. Mattingly, Deborah Morse, Michelle A. King, John D. Iwaniec, Jamal M. Alzahrani, Thomas L. Clanton
Summary: The study revealed that Myd88 signaling in skeletal muscle plays a significant role in the innate immune inflammatory response to peritoneal sepsis, affecting the regulation of inflammatory cytokines and the cellular composition of the peritoneal fluid.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru
Summary: This study found that treatment with FasL-overexpressing MSC can improve GvHD and increase survival in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jin Kyung Kim, Eun-Jin Park, Eun-Kyeong Jo
Summary: Immune metabolic regulation plays a crucial role in the host-pathogen interaction during tuberculosis infection. Metabolites such as itaconate, L-arginine, and L-citrulline are involved in innate immune protection against Mycobacterium tuberculosis, by restricting bacterial growth and enhancing host defense mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Derrick R. Samuelson, Sabah Haq, Daren L. Knoell
Summary: Manganese and zinc are essential micronutrients that play a crucial role in regulating host immune response against infections. The metal transporter ZIP8 plays a key role in metal uptake and affects host defense mechanisms. Perturbations in metal homeostasis may impact the composition of bacterial communities in the host. Therefore, understanding the importance of zinc and manganese uptake is important for the development of intervention strategies against infectious diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Peter Mancuso, Jeffrey L. Curtis, Anne M. Weitzel, Cameron A. Griffin, Benjamin Bouchard, Christine M. Freeman, Dave Bridges, Kanakadurga Singer
Summary: Diet-induced obesity impairs pulmonary clearance of Klebsiella and enhances blood dissemination by reducing neutrophil killing and reactive oxygen intermediate production due to impaired glucose transport.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Allergy
Masayuki Nakajima, Mio Kawaguchi, Masashi Matsuyama, Kyoko Ota, Junichi Fujita, Satoshi Matsukura, Shau-Ku Huang, Yuko Morishima, Yukio Ishii, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2018)
Letter
Allergy
Jun Kanazawa, Hironori Masuko, Hideyasu Yamada, Yohei Yatagai, Tohru Sakamoto, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
ALLERGOLOGY INTERNATIONAL
(2018)
Article
Allergy
Jun Kanazawa, Hironori Masuko, Yohei Yatagai, Tohru Sakamoto, Hideyasu Yamada, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
ALLERGOLOGY INTERNATIONAL
(2019)
Article
Genetics & Heredity
Jun Kanazawa, Haruna Kitazawa, Hironori Masuko, Yohei Yatagai, Tohru Sakamoto, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Masaharu Nishimura, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
BMC MEDICAL GENETICS
(2019)
Article
Multidisciplinary Sciences
Fumi Mochizuki, Hiroaki Iijima, Azusa Watanabe, Naoya Tanabe, Susumu Sato, Masanari Shiigai, Keiji Fujiwara, Takafumi Shimada, Hiroichi Ishikawa, Jun Kanazawa, Yohei Yatagai, Hironori Masuko, Tohru Sakamoto, Shigeo Muro, Nobuyuki Hizawa
SCIENTIFIC REPORTS
(2019)
Article
Respiratory System
Hideyasu Yamada, Norihito Hida, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2020)
Article
Allergy
Haruna Kitazawa, Hironori Masuko, Jun Kanazawa, Rie Shigemasa, Kentaro Hyodo, Hideyasu Yamada, Yohei Yatagai, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Tomomitsu Hirota, Mayumi Tamari, Tohru Sakamoto, Nobuyuki Hizawa
Summary: The study revealed that the ORMDL3/GSDMB gene locus on chromosome 17q is associated with childhood-onset adult asthma in Japanese populations, leading to elevated total serum IgE levels in patients, but not allergic sensitization.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Allergy
Rie Shigemasa, Hironori Masuko, Kentaro Hyodo, Haruna Kitazawa, Jun Kanazawa, Yohei Yatagai, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Tomomitsu Hirota, Mayumi Tamari, Tohru Sakamoto, Nobuyuki Hizawa
CLINICAL AND EXPERIMENTAL ALLERGY
(2020)
Letter
Allergy
Rie Shigemasa, Hironori Masuko, Hisayuki Oshima, Kentaro Hyodo, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
ALLERGOLOGY INTERNATIONAL
(2021)
Letter
Allergy
Haruna Kitazawa, Hironori Masuko, Jun Kanazawa, Rie Shigemasa, Kentaro Hyodo, Hideyasu Yamada, Yohei Yatagai, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Tomomitsu Hirota, Mayumi Tamari, Tohru Sakamoto, Nobuyuki Hizawa
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Yohei Yatagai, Hisayuki Oshima, Tohru Sakamoto, Rie Shigemasa, Haruna Kitazawa, Kentaro Hyodo, Hironori Masuko, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
Summary: ETS variant transcription factor 4 (ETV4) is a newly identified transcription factor that has been found to regulate gene expression linked to asthma and IL6 production. Genetic association studies using Japanese cohorts identified significant associations between SNPs near ETV4 and MEOX1 with adult asthma, indicating potential independent effects on asthma development. The risk alleles at these SNPs were also correlated with increased levels of ETV4 mRNA expression and serum IL6 levels, suggesting a role for ETV4 in asthma pathogenesis through heightened IL6 production.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Kentaro Hyodo, Hironori Masuko, Hisayuki Oshima, Rie Shigemasa, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Hiroichi Ishikawa, Takahide Kodama, Akihiro Nomura, Katsunori Kagohashi, Hiroaki Satoh, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
Summary: This study aimed to investigate the exacerbation-prone phenotypes beyond disease labels in asthma and COPD using shared risk factors and to examine the role of the IL4RA gene polymorphism related to type 2 inflammation. The results showed common exacerbation-prone endotypes in chronic inflammatory airway diseases, supporting the use of a treatable traits approach for prevention.
Editorial Material
Respiratory System
Hiroko Watanabe, Hiroaki Ishikawa, Toshihide Inui, Kai Kawashima, Tomohiro Namiki, Tohru Sakamoto
Summary: This article describes a rare complication of interstitial pneumonia - tension pneumomediastinum, and presents the computed tomography findings of the Macklin effect, in which air dissection along the bronchovascular interstitium caused by alveolar rupture leads to pneumomediastinum.
RESPIROLOGY CASE REPORTS
(2022)
Article
Oncology
Yuka Aida, Kensuke Nakazawa, Toshihiro Shiozawa, Ryoko Ogawa, Takumi Kiwamoto, Yuko Morishima, Toru Sakamoto, Ikuo Sekine, Nobuyuki Hizawa
CASE REPORTS IN ONCOLOGY
(2019)
Article
Immunology
Masayuki Nakajima, Mio Kawaguchi, Kyoko Ota, Junichi Fujita, Satoshi Matsukura, Shau-Ku Huang, Yuko Morishima, Yukio Ishii, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa
IMMUNITY INFLAMMATION AND DISEASE
(2017)