Article
Biochemistry & Molecular Biology
M. Beukema, K. Ishisono, J. de Waard, M. M. Faas, P. de Vos, K. Kitaguchi
Summary: Pectin exhibits antimicrobial effects, protecting the epithelial barrier from damage caused by C. rodentium, and also reduces its adhesive properties to epithelial cells.
Article
Nutrition & Dietetics
Tatsuki Kimizuka, Natsumi Seki, Genki Yamaguchi, Masahiro Akiyama, Seiichiro Higashi, Koji Hase, Yun-Gi Kim
Summary: The study showed that an amino acid-based diet protected mice from enteric pathogen infection by preventing dehydration caused by diarrhea, altering amino acid levels in the plasma and feces as well as changing gut microbiota composition.
Article
Food Science & Technology
Yunchang Zhang, Da Jiang, Yuhang Jin, Hai Jia, Ying Yang, In Ho Kim, Zhaolai Dai, Jinhua Zhang, Fazheng Ren, Zhenlong Wu
Summary: The study showed that glycine supplementation is beneficial in alleviating colitis induced by C. rodentium, reducing disease index and colon pathology. Glycine protects colon epithelial cells from apoptosis by suppressing inflammatory cell activation and increasing the abundance of lactobacilli.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Wei Wu, Dongsheng Zhou, Rongrong Xuan, Jiawei Zhou, Jingwangwei Liu, Juanjuan Chen, Hui Han, Tingting Niu, Xingxing Li, Haimin Chen, Feng Wang
Summary: This study found that lambda-CGN may create an environment that favors inflammation by altering gut microbiota composition and gut bacterial metabolism. The evidence suggests that the gut microbiota-barrier axis could be an alternative target for ameliorating the colitis promoting effect of lambda-CGN.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Tengfei Wang, Lixiang Li, Shiyang Li, Hongyu Zhao, Junyan Qu, Yanan Xia, Yanqing Li
Summary: The study shows that C. butyricum can alleviate visceral hypersensitivity induced by C. rodentium infection plus chronic stress in mice, and also modify the microbiota changes caused by infection and chronic stress. C. butyricum may be a more effective treatment strategy for PI-IBS than antibiotics.
Article
Biochemistry & Molecular Biology
Fang Liu, Allen D. D. Smith, Thomas T. Y. Wang, Quynhchi Pham, Haiyan Yang, Robert W. W. Li
Summary: As a key bioactive food ingredient in pomegranate, punicalagin (PA) has various functional activities. However, the understanding of PA-modulated microbial interactions and their physiological relevance in the gastrointestinal tract is limited. This study explored the effects of PA on host-microbiota interactions using multi-omics approaches in two colitis models, and found that PA could dampen intestinal inflammation, regulate gut microbial diversity, and restore microbial dysbiosis caused by colitis. Our findings also identified microbial signatures that can serve as biomarkers for monitoring the efficacy of PA-containing functional foods in promoting gut health. These results provide insights into the dual applications of PA as a bioactive food ingredient and a therapeutic agent.
Article
Chemistry, Multidisciplinary
Ana Garcia-Garcia, Thomas Hicks, Samir El Qaidi, Congrui Zhu, Philip R. Hardwidge, Jesus Angulo, Ramon Hurtado-Guerrero
Summary: NleB/SseK effectors modify host cell proteins through Tyr284 residue to regulate substrate selectivity, ultimately affecting bacterial virulence in a host-specific manner.
Review
Biochemistry & Molecular Biology
Julia Sanchez-Garrido, David Ruano-Gallego, Jyoti S. Choudhary, Gad Frankel
Summary: Recent studies have shown that T3SS effectors interact with each other in the host, revealing their interdependency and context-dependent essentiality, which is of great significance for understanding the pathogenesis of the pathogens.
TRENDS IN MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Yunchang Zhang, Tianqi Mu, Ying Yang, Jinhua Zhang, Fazheng Ren, Zhenlong Wu
Summary: This study showed that supplementation with Lactobacillus johnsonii can effectively prevent Citrobacter rodentium-induced colitis in mice by reducing inflammation levels and cell apoptosis, while increasing immune cell infiltration significantly.
JOURNAL OF NUTRITION
(2021)
Article
Oncology
Yue Liu, Kai Fu, Eric M. Wier, Yifan Lei, Andrea Hodgson, Dongqing Xu, Xue Xia, Dandan Zheng, Hua Ding, Cynthia L. Sears, Jian Yang, Fengyi Wan
Summary: This study identified a novel genotoxin called UshA in attaching/effacing pathogens, which triggers DNA damage and initiates tumorigenic transformation during bacterial infections. Furthermore, it was found that UshA plays a critical role in accelerating colon tumorigenesis in mice. These findings highlight the importance of UshA in the development of colon cancer caused by bacterial infections.
Article
Immunology
Ashley Gilliland, Christina Gavino, Samantha Gruenheid, Tracy Raivio
Summary: The Cpx envelope stress response is crucial for C. rodentium to adapt to stress in the gastrointestinal tract and play a role in its pathogenesis. This study found that the absence of the Cpx ESR resulted in higher expression of a master regulator of virulence genes and affected the proper expression of several genes in C. rodentium. The Delta cpxRA mutant exhibited reduced colonization and attenuated virulence, possibly due to defective growth in the colonic environment caused by the combined impact of multiple Cpx-regulated genes.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
Eunha Kim, Donggi Paik, Ricardo N. Ramirez, Delaney G. Biggs, Youngjun Park, Ho-Keun Kwon, Gloria B. Choi, Jun R. Huh
Summary: The study reveals that mouse offspring exposed to maternal inflammation during pregnancy are more prone to intestinal inflammation later in life, and interleukin-17A can generate immune-primed phenotypes in offspring by altering the maternal gut microbiota. This provides insights into why children exposed to heightened inflammation in the womb may have an increased risk of developing inflammatory diseases in addition to neurodevelopmental disorders.
Article
Gastroenterology & Hepatology
Yvonne L. L. Latour, Margaret M. M. Allaman, Daniel P. P. Barry, Thaddeus M. M. Smith, Kamery J. J. Williams, Kara M. M. McNamara, Justin Jacobse, Jeremy A. A. Goettel, Alberto G. G. Delgado, M. Blanca Piazuelo, Shilin Zhao, Alain P. P. Gobert, Keith T. T. Wilson
Summary: Lack of talin-1 in intestinal epithelial cells increases susceptibility to colonic disease caused by pathogenic Escherichia coli, leading to decreased survival, increased colonization, colon weight, and histologic colitis. Loss of talin-1 in colonic epithelial cells impairs recruitment and activation of T cells, exacerbating colonic mucosal hyperplasia and cell crowding in the glands.
Article
Microbiology
Jun Bong Lee, Se Kye Kim, Dalmuri Han, Jang Won Yoon
Summary: For the first time, it is shown that disrupting both relA and spoT genes in enteropathogenic Escherichia coli E2348/69 can attenuate its virulence and induce interleukin 6 (IL-6) in vivo. Whole genome-scale transcriptomic analysis revealed differential expression of 1,564 EPEC genes in the Delta relA Delta spoT double mutant strain. Depletion of relA and spoT attenuated the virulence of E2348/69 and induced IL-6 in porcine macrophages.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Naheed Choudhry, Flora Scott, Meghan Edgar, Gareth J. Sanger, Paul Kelly
Summary: Environmental enteropathy is associated with chronic low-grade intestinal inflammation and disrupted epithelial barrier integrity, leading to bacterial translocation. Contra-pathogenicity therapies can mitigate enteropathogen-mediated damage to the intestinal epithelial barrier.
DIGESTIVE DISEASES AND SCIENCES
(2021)