Article
Gastroenterology & Hepatology
Jorge Pena-Diaz, Sarah E. Woodward, Anna Creus-Cuadros, Antonio Serapio-Palacios, Stephanie Ortiz-Jimenez, Wanyin Deng, B. Brett Finlay
Summary: Quorum sensing is a form of communication that allows bacteria to modify their behavior based on population density. In the mammalian digestive tract, the use of quorum sensing by bacteria remains understudied. This study found that the pathogen Citrobacter rodentium utilizes a quorum sensing system to regulate virulence, and inhibiting quorum sensing actually enhances its virulence.
Editorial Material
Immunology
Shantanu Bhatt
Summary: The study suggests that kittens may serve as a reservoir for aEPEC pathogens, and the hypermotility of diarrheic E. coli strains may be associated with their virulence.
INFECTION AND IMMUNITY
(2021)
Article
Gastroenterology & Hepatology
Maximilian Baumgartner, Rebecca Zirnbauer, Sabine Schlager, Daniel Mertens, Nikolaus Gasche, Barbara Sladek, Craig Herbold, Olga Bochkareva, Vera Emelianenko, Harald Vogelsang, Michaela Lang, Anton Klotz, Birgit Moik, Athanasios Makristathis, David Berry, Stefanie Dabsch, Vineeta Khare, Christoph Gasche
Summary: With increasing urbanization and industrialization, the prevalence of inflammatory bowel diseases (IBDs) has been rising over the past two decades. This study found that the emerging pathogen atypical enteropathogenic E. coli (aEPEC) is associated with disease activity in ulcerative colitis (UC) patients, and it may disrupt immune-microbiota homeostasis.
Review
Biochemistry & Molecular Biology
Julia Sanchez-Garrido, David Ruano-Gallego, Jyoti S. Choudhary, Gad Frankel
Summary: Recent studies have shown that T3SS effectors interact with each other in the host, revealing their interdependency and context-dependent essentiality, which is of great significance for understanding the pathogenesis of the pathogens.
TRENDS IN MICROBIOLOGY
(2022)
Article
Oncology
Yue Liu, Kai Fu, Eric M. Wier, Yifan Lei, Andrea Hodgson, Dongqing Xu, Xue Xia, Dandan Zheng, Hua Ding, Cynthia L. Sears, Jian Yang, Fengyi Wan
Summary: This study identified a novel genotoxin called UshA in attaching/effacing pathogens, which triggers DNA damage and initiates tumorigenic transformation during bacterial infections. Furthermore, it was found that UshA plays a critical role in accelerating colon tumorigenesis in mice. These findings highlight the importance of UshA in the development of colon cancer caused by bacterial infections.
Article
Medicine, Research & Experimental
Jeffrey L. Platt, Mayara Garcia de Mattos Barbosa, Daniel Huynh, Adam R. Lefferts, Juhi Katta, Cyra Kharas, Peter Freddolino, Christine M. Bassis, Christiane Wobus, Raif Geha, Richard Bram, Gabriel Nunez, Nobuhiko Kamada, Marilia Cascalho
Summary: The study found that a common human variant, TNFRSF13B A181E, confers resistance to enteric pathogens in mice, primarily due to natural IgA deficiency in the intestine. In both WT mice and mutant mice reconstituted with enteric IgA from WT mice, IgA induces the expression of virulence genes, leading to pathogenicity and transmission.
Article
Food Science & Technology
Peter Kotsoana Montso, Cornelius Carlos Bezuidenhout, Charlotte Mienie, Yinka M. Somorin, Olumide A. Odeyemi, Victor Mlambo, Collins Njie Ateba
Summary: This study investigated the genetic diversity, virulence, and antimicrobial resistance of atypical enteropathogenic E. coli O177 strains isolated from cattle feces in South Africa. The findings showed that cattle carry genetically diverse E. coli O177 strains with a repertoire of virulence and resistance genes, highlighting the need for surveillance of multidrug resistant E. coli O177 strains in cattle.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Peter Kotsoana Montso, Victor Mlambo, Collins Njie Ateba
Summary: This study presents the whole genome sequence data of two aEPEC E. coli O177 isolates, providing insights into their genomic structure, virulence factors, and antimicrobial resistance.
Article
Pediatrics
Petra Zimmermann, Kirsten P. Perrett, Nicole Ritz, Katie L. Flanagan, Roy Robins-Browne, Fiona R. M. van der Klis, Nigel Curtis, Veronica Abruzzo, Katie Allen, Rhian Bonnici, Dan Casalaz, Hannah Elborough, Bridget Freyne, Kaya Gardiner, Susie Germano, Tobias Kollmann, Nicole Messina, Clare Morrison, Helder Nakaya, Anne Louise Ponsonby, Frank Shann, Mike South, Peter Vuillermin
Article
Immunology
Bridget Freyne, Nicole L. Messina, Susan Donath, Susie Germano, Rhian Bonnici, Kaya Gardiner, Dan Casalaz, Roy M. Robins-Browne, Mihai G. Netea, Katie L. Flanagan, Toby Kollmann, Nigel Curtis
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Public, Environmental & Occupational Health
Myron M. Levine, Dilruba Nasrin, Sozinho Acacio, Quique Bassat, Helen Powell, Sharon M. Tennant, Samba O. Sow, Dipika Sur, Anita K. M. Zaidi, Abu S. G. Faruque, M. Jahangir Hossain, Pedro L. Alonso, Robert F. Breiman, Ciara E. O'Reilly, Eric D. Mintz, Richard Omore, John B. Ochieng, Joseph O. Oundo, Boubou Tamboura, Doh Sanogo, Uma Onwuchekwa, Byomkesh Manna, Thandavarayan Ramamurthy, Suman Kanungo, Shahnawaz Ahmed, Shahida Qureshi, Farheen Quadri, Anowar Hossain, Sumon K. Das, Martin Antonio, Debasish Saha, Inacio Mandomando, William C. Blackwelder, Tamer Farag, Yukun Wu, Eric R. Houpt, Jaco J. Verweiij, Halvor Sommerfelt, James P. Nataro, Roy M. Robins-Browne, Karen L. Kotloff
LANCET GLOBAL HEALTH
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Michael McKinley, Kaylani Almeida, Sammy Bedoui, David Farmer, Dianna Hocking, Yugeesh Lankadeva, Davide Martelli, Clive May, Roy Robins-Browne, Robin McAllen
Editorial Material
Biochemistry & Molecular Biology
Elizabeth L. Hartland
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Yugeesh R. Lankadeva, Clive N. May, Michael J. McKinley, Melanie R. Neeland, Shuai Ma, Dianna M. Hocking, Roy Robins-Browne, Sammy Bedoui, David G. S. Farmer, Simon R. Bailey, Davide Martelli, Robin M. McAllen
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Laure F. Pittet, Marc Tebruegge, Binita Dutta, Susan Donath, Nicole Messina, Dan Casalaz, Willem A. Hanekom, Warwick J. Britton, Roy Robins-Browne, Nigel Curtis, Nicole Ritz
Summary: BCG vaccination induces M. ulcerans-specific immune responses in infants, likely explaining the cross-protective effect observed in epidemiological studies. These immune responses show similar patterns to those observed in M. tuberculosis-stimulated samples.
Review
Microbiology
Manal H. Alshareef, Elizabeth L. Hartland, Kathleen McCaffrey
Summary: The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. It plays a crucial role in host defense against bacterial infection, but UPR-mediated apoptosis can also contribute to tissue damage and disease.
Article
Cell Biology
Sze Ying Ong, Ralf Schuelein, Rachelia R. Wibawa, Daniel W. Thomas, Yanny Handoko, Saskia Freytag, Melanie Bahlo, Kaylene J. Simpson, Elizabeth L. Hartland
Summary: The host ubiquitin pathways play a crucial role in the efficiency of Dot/Icm effector translocation by L. pneumophila. Host-derived ubiquitin-conjugating enzymes and ubiquitin ligases participate in the translocation of Legionella effector proteins, influencing intracellular persistence and survival.
CELLULAR MICROBIOLOGY
(2021)
Editorial Material
Cell Biology
Elizabeth L. Hartland
CELLULAR MICROBIOLOGY
(2021)
Article
Microbiology
Cristina Giogha, Nichollas E. Scott, Tania Wong Fok Lung, Georgina L. Pollock, Marina Harper, Ethan D. Goddard-Borger, Jaclyn S. Pearson, Elizabeth L. Hartland
Summary: During infection, bacterial pathogens EPEC and EHEC use type III secretion system to inject effector proteins into host cells, directly manipulating host cell functions. NleB2, a close homologue of NleB1, is the first identified bacterial arginine-glucose transferase, inhibiting host protein function through arginine glycosylation, similar to NleB1's Arg-GlcNAc glycosylation. Substitution of specific residues in NleB2 and NleB1 switches sugar donor usage without affecting their ability to inhibit host cell signaling.
Article
Critical Care Medicine
Laure F. Pittet, Nora Fritschi, Marc Tebruegge, Binita Dutta, Susan Donath, Nicole L. Messina, Dan Casalaz, Willem A. Hanekom, Warwick J. Britton, Roy Robins-Browne, Nigel Curtis, Nicole Ritz
Summary: The presence of a scar after BCG vaccination is associated with stronger mycobacteria-specific T-cell responses. Further study on the relationship between scar formation and protection against tuberculosis as well as the need for revaccination in scar-negative individuals is important.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kevin Voth, Shivani Pasricha, Ivy Yeuk Wah Chung, Rachelia R. Wibawa, Engku Nuraishah Huda E. Zainudin, Elizabeth L. Hartland, Miroslaw Cygler
Summary: Legionella pneumophila is a Gram-negative intracellular pathogen causing Legionnaires' disease, using a secretion system and effector proteins to colonize host cells. MavL may play a role in cell signaling by binding ADP-ribose, and interacts with the mammalian ubiquitin-conjugating enzyme.
Article
Cell Biology
Elizabeth L. Hartland, Debnath Ghosal, Cristina Giogha
Summary: Subversion of host cell cytoskeleton by bacterial pathogens is a common virulence attribute. This review highlights recent studies that enhance our understanding of the mechanical and molecular processes of pathogen invasion, cell-to-cell spread, and the impact of infection on epithelial intercellular tension and innate mucosal defense.
CURRENT OPINION IN CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
A. Salpietro, V Sinatra, V Mottola, A. Ceravolo, V Chirico, L. Colavita, G. Ceravolo, E. Gitto, C. Cuppari, R. Chimenz
Summary: HUS is a thrombotic microangiopathy characterized by thrombocytopenia, non-immune microangiopathic hemolytic anemia, and acute kidney injury. It can be classified into typical and atypical types, with common pathogenetic features including damage of endothelial cells, intravascular hemolysis, coagulation abnormalities, and microthrombus formation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)