Article
Biotechnology & Applied Microbiology
Errol Moras, Basavaprabhu Achappa, B. Murlimanju, G. M. Naveen Raj, Ramesh Holla, Deepak Madi, Nikhil Victor D'Souza, Soundarya Mahalingam
Summary: The aim of this study was to investigate whether serum ferritin and gall bladder wall edema could predict the severity of dengue fever. The results showed a significant correlation between serum ferritin levels, gall bladder wall thickness, and the severity of dengue fever.
Review
Virology
Shridhar Shukla, Santosh M. Jadhav, Yogesh K. Gurav, Deepti Parashar, Kalichamy Alagarasu
Summary: This study evaluated the association between serum ferritin levels and severe dengue, as well as its utility as a biomarker of disease severity. The analysis included 18 studies and found that serum ferritin levels were higher in severe dengue cases compared to non-severe cases.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Virology
Anh N. Ly, Russell Manzanero, Adrianna Maliga, Sarah M. Gunter, Shannon E. Ronca, Emily Zielinski-Gutierrez, Francis Morey, Kim Bautista, Andres Espinosa-Bode, Beatriz Lopez, Loren Cadena, Rafael C. Fuentes, Timothy A. Erickson, Flor M. Munoz, Joy Mackey, Gerhaldine Morazan, Kristy O. Murray
Summary: This study describes the epidemiology of dengue virus infections in Belize diagnosed through AFI surveillance in 2020. Results showed that all four DENV serotypes were detected, with two cases of DENV serotype 4, the first report of this serotype in Belize since 2004. The majority of DENV cases were diagnosed in the Belize District during the dry season. Understanding the epidemiology and clinical characteristics of DENV is crucial for public health interventions to mitigate transmission.
Article
Environmental Sciences
Syarifah Syahirah Syed Abas, Noralisa Abdul Karim, Petrick Periyasamy, Nurasyikin Yusof, Shamsul Azhar Shah, Tan Toh Leong, Saiful Safuan Md Sani, Hanita Othman, Sharifah Azura Salleh, Nurul Nadiah Mohd Zaidi, S. Fadilah Abdul Wahid, Wan Fariza Wan Jamaludin
Summary: This study analyzed the associations between warning signs and hemorrhage in dengue patients with ROTEM, platelet count, cortisol, and ferritin levels. The results showed that vomiting, hematocrit increase, and platelet decrease were correlated with ROTEM, indicating their potential as markers for hemorrhage. Blood loss affected platelet function and clot formation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Elzbieta Lazar-Poloczek, Ewa Romuk, Piotr Rozentryt, Sylwia Duda, Mariusz Gasior, Celina Wojciechowska
Summary: This study found a correlation between ceruloplasmin levels and various biomarkers in patients with HFrEF, suggesting ceruloplasmin's potential as a useful biomarker in this population. Ceruloplasmin was positively correlated with cardiac and hepatic status, inflammatory markers, and oxidative stress indicators. These results provide new insights for classification and treatment strategies for HFrEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Liang En Wee, Edwin Philip Conceicao, Jean Xiang-Ying Sim, May Kyawt Aung, Aung Myat Oo, Yang Yong, Shalvi Arora, Indumathi Venkatachalam
Summary: The study found that routine COVID-19 testing for febrile patients with viral prodromes can mitigate infection risk, although it also leads to increased length-of-stay for dengue cases admitted initially to isolation.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jun Ma, Xiao-Long Lv, Xu Zhang, Shu-Zheng Han, Ze-Dong Wang, Liang Li, He-Ting Sun, Li-Xin Ma, Zheng-Lei Cheng, Jian-Wei Shao, Chen Chen, Ying-Hua Zhao, Liyan Sui, Lin-Na Liu, Jun Qian, Wei Wang, Quan Liu
Summary: A new Orthonairovirus, Songling virus (SGLV), was identified in patients bitten by ticks in Heilongjiang Province, China. SGLV displayed similar features to other Orthonairoviruses and formed a unique clade within the Tamdy Orthonairovirus in the Nairoviridae family. Infection with SGLV caused symptoms like headache, fever, depression, fatigue, and dizziness in hospitalized patients, with 69% developing virus-specific antibodies in the acute phase, indicating its association with human febrile illness in China.
Article
Gastroenterology & Hepatology
Elena Corradini, Elena Buzzetti, Paola Dongiovanni, Stefania Scarlini, Angela Caleffi, Serena Pelusi, Isabella Bernardis, Paolo Ventura, Raffaela Rametta, Elena Tenedini, Enrico Tagliafico, Anna Ludovica Fracanzani, Silvia Fargion, Antonello Pietrangelo, Luca Vittorio Valenti
Summary: This study identified variants in non-HFE iron genes, particularly ceruloplasmin, that are associated with hyperferritinemia and increased hepatic iron storage in patients with NAFLD. Carriers of these variants are more likely to have severe liver fibrosis, suggesting a genetic predisposition to hepatic iron deposition that may contribute to liver disease progression.
JOURNAL OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Stylianos Bournazos, Hoa Thi My Vo, Veasna Duong, Heidi Auerswald, Sowath Ly, Anavaj Sakuntabhai, Philippe Dussart, Tineke Cantaert, Jeffrey Ravetch
Summary: Antibodies against dengue virus can enhance disease susceptibility instead of providing protection. The fucosylation status of IgG1 plays a key role in predicting dengue disease severity, while antibody titers and neutralizing activity do not correlate with disease severity. Thus, IgG1 fucosylation status can serve as a robust prognostic tool for dengue disease.
Article
Public, Environmental & Occupational Health
Kerstin D. Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra, Varun Kumar, Lucy Chai See Lum, Jameela Sathar, Ernesto Pleite's Sandoval, Gabriela M. Maron, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker, Ridwanur Rahman, Andrea Caprara, Bruno Souza Benevides, Ernesto T. A. Marques, Tereza Magalhaes, Patricia Brasil, Guilherme Amaral Calvet, Adriana Tami, Sarah E. Bethencourt, Tam Dong Thi Hoai, Kieu Nguyen Tan Thanh, Ngoc Tran Van, Nam Nguyen Tran, Viet Do Chau, Sophie Yacoub, Kinh Nguyen Van, Maria G. Guzman, Pedro A. Martinez, Quyen Nguyen Than Ha, Cameron P. Simmons, Bridget A. Wills, Ronald B. Geskus, Thomas Jaenisch
Summary: This study aimed to improve the early diagnosis of dengue, especially in resource-limited settings where distinguishing dengue from other febrile illnesses is crucial. The study found that platelet count and white blood cell count were strongly associated with dengue, and the importance of serial measurements over time was highlighted.
LANCET GLOBAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Patrick Gerardin, Olivier Maillard, Lea Bruneau, Frederic Accot, Florian Legrand, Patrice Poubeau, Rodolphe Manaquin, Fanny Andry, Antoine Bertolotti, Cecile Levin
Summary: This cohort study developed two scores to differentiate COVID-19 and dengue from other febrile illnesses. These scores, validated through multinomial logistic regression and bootstrapping, showed high accuracy and reliability in predicting the respective diseases. The study concluded that the COVIDENGUE scores were effective in distinguishing COVID-19 and dengue from other febrile illnesses in a co-epidemic setting at a SARS-CoV-2 testing center.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Immunology
Qier Chen, Rong Li, Bolin Wu, Xu Zhang, Hui Zhang, Ran Chen
Summary: Dengue fever, caused by the dengue virus, is a global health threat. Developing a safe and effective vaccine is challenging due to antibody-dependent enhancement (ADE). Researchers have successfully developed a tetravalent nanoparticle vaccine that induces potent immune responses and protects against DENV-2 and DENV-3 challenges in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Immunology
John B. Fournier, Lucas S. Blanton, Nivison Nery Jr, Elsio A. Wunder Jr, Federico Costa, Mitermayer G. Reis, Guilherme S. Ribeiro, David H. Walker, Albert I. Ko
Summary: Enhanced acute febrile illness surveillance in an urban slum community in Salvador, Brazil revealed that rickettsial infection accounted for 3.5% of urgent care visits for acute fever, suggesting it might be an underrecognized, treatable cause of acute febrile illness in impoverished urban populations in Brazil.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Nicole Maier, Mark S. Riddle, Ramiro Gutierrez, Jamie A. Fraser, Patrick Connor, David R. Tribble, Chad K. Porter
Summary: This study aimed to develop a standardized scoring system to assess the severity of travelers' diarrhea (TD), and the newly developed disease severity score better predicted a negative impact on activity due to TD than any single sign or symptom.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Shih Keng Loong, Mohamad Azlan Abd-Majid, Boon Teong Teoh, Mi Jing Cheh, Chee Sieng Khor, Chien Chung Chao, Jing Jing Khoo, Sazaly AbuBakar
Summary: In recent years, there has been a significant increase in the number of leptospirosis cases in Malaysia. A study found that 4.7% of febrile patients with dengue-like illness had leptospirosis, and 18% had positive anti-Leptospira IgM antibodies. Furthermore, one patient was found to be co-infected with leptospirosis and chikungunya virus.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Virology
Daisy Mariya Samadanam, Krishna Raja Muthuraman, Vignesh Mariappan, Tamilarasu Kadhiravan, Narayanan Parameswaran, Agiesh Kumar Balakrishna Pillai, Soundravally Rajendiran
Article
Immunology
Agieshkumar Balakrishna Pillai, Cleetus Cherupanakkal, Jeffrey Immanuel, Elanthiraiyan Saravanan, Vignewswari Eswar Kumar, A. Akshayavardhini, Tamilarasu Kadhiravan, Soundravally Rajendiran
IMMUNOLOGICAL INVESTIGATIONS
(2020)
Review
Biochemistry & Molecular Biology
Vignesh Mariappan, S. R. Rao, Agieshkumar Balakrishna Pillai
Article
Medical Laboratory Technology
V. I. G. N. E. S. H. MARIAPPAN, S. H. A. L. I. N. D. A. ADIKARI, L. O. K. E. S. H. SHANMUGAM, J. O. S. H. Y. M. EASOW, A. G. I. E. S. H. K. U. M. A. R. B. A. L. A. K. R. I. S. H. N. A. PILLAI
Summary: Protein and mRNA levels of ENG and SDC-1 increase significantly towards defervescence in dengue cases, with higher levels in severe dengue cases compared to controls. Support Vector Machine analysis shows that serum levels of ENG and SDC-1, along with other clinical symptoms, can predict disease severity with 100% accuracy.
TRANSLATIONAL RESEARCH
(2021)
Article
Immunology
Vignesh Mariappan, P. S. Manoharan, R. Pajanivel, Lokesh Shanmugam, S. R. Rao, Agieshkumar Balakrishna Pillai
Summary: The current pandemic caused severe damage across various sectors globally, with unclear disease pathogenesis leading to unpredictable clinical outcomes. Developing prognostic biomarkers for predicting COVID-19 patient condition is crucial for efficient patient management.
MICROBIAL PATHOGENESIS
(2021)
Article
Public, Environmental & Occupational Health
V. Nirmal Coumare, Swati Jayant Pawar, P. S. Manoharan, R. Pajanivel, Lokesh Shanmugam, Hemanth Kumar, Abhijit V. Boratne, Balanehru Subramanian, Joshy M. Easow, B. Sivaprakash, R. Kalaivani, K. Renuka, S. Prabavathy, Kripa Angeline, Agieshkumar Balakrishna Pillai, S. R. Rao
Summary: Health care setups face challenges such as addressing hospital preparedness and response quickly, adjusting policies and guidelines to local conditions, enhancing training for healthcare workers, and managing supply chains during the COVID-19 pandemic.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Virology
Agiesh Kumar Balakrishna Pillai, Justin Jang Hann Chu, Vignesh Mariappan, Aashika Raagavi JeanPierre
Summary: The research on the role of platelets in modulating host immune responses has become increasingly important. Viruses can interact with platelet receptors and modulate immune responses, and understanding the role of platelets in viral pathogenesis could lead to innovative therapeutic approaches. This review presents the molecular aspects of platelet-flavivirus interactions and their impact on platelet activation, thrombocytopenia, and vascular endothelial leakage. Additionally, it examines the role of platelet-derived factors as biomarkers for predicting disease outcomes, using dengue infection as an example.
CURRENT OPINION IN VIROLOGY
(2022)
Article
Genetics & Heredity
Pratebha Balu, Vignesh Mariappan, Adithan Chandrasekaran, Kennedy Babu, Agieshkumar Balakrishna Pillai
Summary: Differentially expressed structural protein Vimentin was identified in moderate and severe periodontitis, showing significant downregulation at gene and protein level in severe periodontitis. A weak negative correlation was found between Porphyromonas gingivalis load and mRNA levels of Vimentin.
Article
Cell Biology
Agieshkumar Balakrishna Pillai, Aashika Raagavi JeanPierre, Vignesh Mariappan, Pajanivel Ranganadin, S. R. Rao
Summary: The release of free radicals caused by oxidative stress is increasingly important in the study of viral pathogenesis. Recent studies suggest that oxidative stress and levels of reactive oxygen species (ROS) play a role in regulating disease virulence during RNA virus infections. Most RNA virus infections lead to vascular dysfunction and increased disease severity. However, the biological mechanisms of free radicals in maintaining vascular endothelium integrity are not fully understood. This review discusses common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggests that antioxidant therapy may pave the way for developing therapeutic strategies against emerging and re-emerging RNA viruses.
CELL STRESS & CHAPERONES
(2022)
Article
Genetics & Heredity
Pratebha Balu, Ananya Sweta Venkatesan, Vignesh Mariappan, Jannani Muthu, Agieshkumar Balakrishna Pillai, Saravanakumar Ravindran, Adithan Chandrasekaran
Summary: The study found a slight increase in NLRP3 expression and a significant decrease in P2X7 expression in chronic periodontitis patients, with correlations to periodontal parameters and P. gingivalis load.
Article
Biochemistry & Molecular Biology
Vignesh Mariappan, Pajanivel Ranganadin, Lokesh Shanmugam, S. R. Rao, Agieshkumar Balakrishna Pillai
Summary: This study investigated the plasma ACE2 levels during the early phase of COVID-19 infection and found a significant increase in sACE2 in severe cases. There was also a strong positive correlation between sACE2 and D-dimer, suggesting the potential of sACE2 as a clinical biomarker for disease outcome prediction.
Review
Cell Biology
Agieshkumar Balakrishna Pillai, Vignesh Mariappan, Aashika Raagavi JeanPierre, S. R. Rao
Summary: Endothelial dysfunction is a major complication of emerging and re-emerging viruses, causing vascular leakage and high mortality rates. Mesenchymal stromal/stem cells (MSCs) have emerged as a promising therapeutic strategy for restoring vascular integrity by inhibiting metalloprotease activity, possessing antioxidant properties, and modulating microRNAs.
Article
Biochemistry & Molecular Biology
Vignesh Mariappan, Shalinda Adikari, Lokesh Shanmugam, Joshy M. Easow, Agieshkumar Balakrishna Pillai
Summary: This study found that dengue virus can activate endothelial cells, but the cause of severe dengue is not clear. Guanylate binding proteins (GBPs) secreted by endothelial cells play a role in antioxidant and antiviral responses. The mRNA and protein levels of GBP1 and GBP2 were found to decrease during defervescence in dengue cases, and were associated with oxidative stress. The SVM model showed that protein levels and clinical symptoms can predict disease outcomes with higher precision.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Infectious Diseases
Sojit Tomo, M. Sindhujadevi, Vijay Kumar, S. Sevathy, M. S. Daisy, B. P. Agieshkumar, R. Soundravally
Summary: The study found that in dengue patients, the expression of the DC-SIGN receptor is prolongedly suppressed in patients with plasma leakage, which may be a protective response from the host. The results show that dengue virus infection leads to a decrease in DC-SIGN receptor expression, and it remains suppressed in patients with higher hematocrit.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2021)
Article
Parasitology
Trilokesh Chandrasekaran, Aishwarya Thyagarajan, Prabhakaran Ganapathi Santhakumari, Agiesh Kumar Balakrishna Pillai, Uma Maheswari Krishnan
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2019)