期刊
MATRIX BIOLOGY
卷 48, 期 -, 页码 55-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2015.04.010
关键词
CD44; Hyaluronan; Anoikis; Apoptosis; Epithelial-mesenchymal transition
资金
- NIH [R01CA123359, RR020866, P20 RR16440]
The detachment of normal epithelial cells from matrix triggers an apoptotic response known as anoikis, during homeostatic turnover. Metastatic tumor cells evade anoikis, by mechanisms that are only partly characterized. In particular, the epithelial-mesenchymal transition (EMT) in a subset of invasive tumor cells confers anoikis-resistance. In some cases, EMT up-regulates the cancer stem cell marker CD44S and the enzyme hyaluronic acid synthase-2 (HAS2). CD44S is the major receptor for hyaluronan in the extracellular matrix. Herein, we demonstrate that CD44S, unlike the CD44E isoform expressed in normal epithelial cells, contributes to the protection against anoikis. This protection requires the interaction of CD44S with hyaluronan (HA). CD44S HA interaction is proposed to play an important role in tumor metastasis through enhanced cell survival under detached conditions. (C) 2015 Published by Elsevier B.V.
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