期刊
INDIAN PEDIATRICS
卷 47, 期 9, 页码 785-788出版社
INDIAN ACAD PEDIATRICS
DOI: 10.1007/s13312-010-0118-y
关键词
Cephalosporin; ESBL; Gram negative sepsis; India; NICU
类别
This interventional study with historical controls was conducted to study the effect of cephalosporin restriction on the incidence of extended spectrum beta-lactamase (ESBL) gram negative infections in neonates admitted to intensive care unit. All gram negative isolates from the blood were evaluated for beta lactamase production. The incidence of ESBL production was compared before (year 2007) and after cephalosporin restriction (year 2008). Thirty two neonates (3% of NICU admissions) in the year 2007 and fifty six (5.2%) in the year 2008, had gram negative septicemia. The incidence of ESBL gram negatives decreased by 22% (47% to 25%, P=0.03). Restriction of all class of cephalosporins significantly decreased the incidence of ESBL gram negative infections.
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