Article
Multidisciplinary Sciences
Rasha Mohammed Ibrahim, Hemmat Mansour Abdelhafez, Sawsan Abd EL-Maksoud EL-Shamy, Fatma Ahmed Eid, Alya Mashaal
Summary: The effects of Arabic gum/Gum Acacia (GA) on diabetic rats were investigated in this study. The results showed that Arabic gum treatment increased body weight, decreased glucose levels, increased insulin levels, exerted anti-inflammatory effects, and improved pancreatic tissue structure in diabetic rats. Arabic gum may be a beneficial therapy for diabetes and other autoimmune and inflammatory diseases.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Nisar Ul Haq, Ghulam Mujtaba Shah, Farid Menaa, Rahmat Ali Khan, Norah A. Althobaiti, Aishah E. Albalawi, Huda Mohammed Alkreathy
Summary: This study investigated the use of silver nanoparticles as a model for researching antidiabetic drugs. The results showed that treatment with plant-mediated silver nanoparticles significantly improved dyslipidemia and blood glucose levels in diabetic rats, as well as improving body weight and liver and kidney profiles.
Article
Chemistry, Multidisciplinary
Muhammad Nisar Ul Haq, Ghulam Mujtaba Shah, Alia Gul, Ahmed Ibrahim Foudah, Mohammad Hamed Alqarni, Hasan Soliman Yusufoglu, Masroor Hussain, Huda Mohammed Alkreathy, Ihsan Ullah, Amir Muhammad Khan, Shahid Jamil, Mushtaq Ahmed, Rahmat Ali Khan
Summary: This study evaluated the potential of phyto-synthesised silver nanoparticles as an anti-diabetic therapy and found that it significantly reduced blood glucose levels, increased body weight, and improved lipid, liver, and kidney profiles.
Article
Food Science & Technology
Iftikhar Younis Mallhi, Muhammad Sohaib, Azmat Ullah Khan, Imtiaz Rabbani
Summary: This study investigated the potential of strawberry extracts to lower blood sugar, improve antioxidant levels and reduce blood lipid levels in diabetic rats. The results showed that treatment with strawberry extract at doses of 250, 500, and 750 mg/kg body weight significantly reduced blood glucose levels, improved renal function and lipid profile, and increased body weight and insulin activity.
Article
Pharmacology & Pharmacy
Syed Akif Raza Kazmi, Muhammad Zahid Qureshi, Sadia, Saleh S. Alhewairini, Shaukat Ali, Shazia Khurshid, Muhammad Saeed, Shumaila Mumtaz, Tafail Akbar Mughal
Summary: The study investigated the antidiabetic potential of minocycline-modified silver nanoparticles (mino/AgNPs) against alloxan-induced diabetic mice. The mino/AgNPs demonstrated higher radical scavenging activity and significant improvements in fasting blood glucose level and lipid profile in diabetic mice. Histopathological examination confirmed recovery and revival of kidney, liver, and pancreas morphology in diabetic mice treated with mino/AgNPs, suggesting their potential as nanomedicine for diabetes prevention.
Article
Management
Soheil Ghili, Peter Klibanoff
Summary: This study examines preference conditions in choice under uncertainty and explores the relationship between monotonicity in optimal mixtures and ambiguity-sensitive behavior. It reveals an incompatibility between monotonicity in optimal mixtures and ambiguity aversion for certain classes of preferences exhibiting ambiguity-sensitive behavior. The research also shows that smooth ambiguity preferences can satisfy both properties as long as they are not too ambiguity averse.
MANAGEMENT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Indah Fajarwati, Dedy Duryadi Solihin, Tutik Wresdiyati, Irmanida Batubara
Summary: Alloxan and streptozotocin can induce self-recovery in diabetic animal models, leading to unstable hyperglycemia conditions and affecting the accuracy of examination.
Article
Biochemistry & Molecular Biology
Shahid Rasool, Bassam Al Meslmani, Muaaz Alajlani
Summary: This study investigated the hypoglycemic, hypolipidemic, and nephroprotective effects of Berberis calliobotrys methanol extract/fractions. In vitro anti-glycation activity showed a significant reduction in glycated end-products formation. In vivo experiments demonstrated a decline in glucose concentration, improved lipid profile, and kidney function.
Article
Biochemistry & Molecular Biology
Tahreem Tanweer, Nosheen Fatima Rana, Iqra Saleem, Iqra Shafique, Sultan M. Alshahrani, Hanadi A. Almukhlifi, Amenah S. Alotaibi, Sohad Abdulkaleg Alshareef, Farid Menaa
Summary: This study aimed to enhance the antibacterial potential of resin composite by using Magnesium-doped Zinc oxide (Mg-doped ZnO) nanoparticles (NPs) and test their effectiveness in a diabetes model. The results showed that composites with 1% Mg-doped ZnO had significantly improved antibacterial properties, without affecting the mechanical properties and biocompatibility. Moreover, Mg-doped ZnO composites prevented secondary caries formation in diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Syed Mohammed Taif Rizvi, Benjamin Lenane, Patrick Lam, George A. C. Murrell
Summary: This study compared the outcomes of shoulder arthroplasty performed as a day case and as an inpatient procedure. The results showed that there were no significant differences in complications, hospitalizations, or revision surgeries between the two groups over a minimum two-year follow-up period. However, the day case group had better functional outcomes but reported more pain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Paulla Vieira Rodrigues, Bruna Moreira Silva Lemos, Maria Vitoria da Silva, Tafs de Campos Lima, Debora de Oliveira Santos, Julia Borges Paes Lemes, Celina Monteiro da Cruz Lotufo
Summary: The study compared the effects of streptozotocin and alloxan on diabetes induction in rats, finding that streptozotocin directly affects nociceptive neurons and increases mechanical sensitivity, while alloxan only induces mechanical sensitization in hyperglycemic animals.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2021)
Article
Chemistry, Medicinal
Neha Sharma, Anand Kar, Sunanda Panda, Dhananjay Yadav
Summary: This study found that the combination of Pterocarpus marsupium (PM) extract and glibenclamide (GLB) showed better synergistic effects in regulating hyperglycemia and associated changes in alloxan-induced mice. The major phytoconstituent, epicatechin, in the PM extract was responsible for its antioxidative and glucose-lowering activities. These findings provide new insights into the use of herbal medicine for the treatment of diabetes.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Dermatology
Justin T. Avery, Jizeng Qiao, Erika Medeiros, Thomas J. Bollenbach, Kelly A. Kimmerling, Katie C. Mowry
Summary: A delayed wound healing model was developed to investigate the cellular and molecular mechanisms of porcine autologous bi-layered living cellular constructs (BLCC) in wound healing. Results showed that porcine BLCC treatment significantly accelerated wound healing, primarily through re-epithelialisation.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Abbirami Elangovan, Siva Durairaj, Abinaya Subramanian, Sooraj Ramakrishnan, Dinesh Kumar Lakshmanan, Guna Ravichandran, Sivasudha Thilagar
Summary: The study found that extracts of Momordica cymbalaria not only reduce postprandial blood glucose levels in diabetic rats, but also improve their reproductive health by increasing testosterone levels and sperm count.
Article
Chemistry, Multidisciplinary
Muhammad Tahir Akhtar, Tahira Almas, Samreen Safdar, Mubshara Saadia, Rahman Qadir, Sajida Batool, Muhammad Mustaqeem, Usman Ali Shaukat, Fariha Kanwal, Rujie Cai
Summary: This study investigated the effects of a polyherbal emulsion on antioxidant potential, alpha-amylase inhibitory activity, hypoglycemic, hypolipidemic, and histoprotective effects on alloxan-induced diabetic rats. A stable formulation named F6-SMONSECCE, prepared from extracts and oils of Nigella sativa, Citrullus colocynthis, and Silybum marianum, showed the best antioxidant and alpha-amylase inhibitory activity. In vivo trials with F6-SMONSECCE demonstrated significant antidiabetic, antilipidemic, and antioxidant effects, as well as histopathological normalization of the pancreas and kidney tissues.
