Article
Materials Science, Multidisciplinary
Muniyandi Biruntha, Balan Karunai Selvi, James Arockia John Paul, Pethanan Sivakumar, Sundararaj Rajamanikandan, Dhamodharan Prabhu
Summary: This study focused on synthesizing silver nanoparticles using the ethanolic leaf extract of Tinospora cordifolia and evaluated their antioxidant, hepato and nephro-protective effects. The results showed that the treatment with the silver nanoparticles restored the serum levels of urea, creatine, uric acid, SGOT and SGPT in mice induced with potassium bromate, indicating their potential therapeutic use. The histopathological study on kidney tissues supported the biochemical observations. Overall, the synthesized AgNPs exhibited strong antioxidant, hepato and nephro-protective effects.
Article
Food Science & Technology
Anshika Jain, Nandita Dasgupta, Shivendu Ranjan, Vineeta Singh, Hemant Singh, Shiv Dutt Purohit, Narayan Chandra Mishra, Narayan Prasad Yadav, Shafiul Haque, Bhartendu Nath Mishra, Sujoy Kumar Samanta
Summary: This study developed an appropriate delivery system for the controlled release of anti-diabetic activity of Tinospora cordifolia, which improved the stability and bioavailability of bioactive compounds. The encapsulation of these compounds in a whey protein isolate core-shell matrix showed promising results for enhancing antidiabetic activity, with potential for further exploration as a novel nutraceutical delivery system.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2021)
Article
Chemistry, Inorganic & Nuclear
Ravi Saini, Pradeep Kumar
Summary: Green synthesis is a cost-effective and eco-friendly method for synthesising nanoparticles. In this study, Tinospora cordifolia plant stem extract was used to synthesise titanium dioxide nanoparticles, which were characterized using various techniques. The synthesized nanoparticles exhibited triangular shape and were able to degrade Acid Blue 113.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Amrita Nandan, Vishwas Sharma, Prodyot Banerjee, Kannan Sadasivam, Subramanian Venkatesan, Bhavana Prasher
Summary: Naive CD4(+) T cells differentiate into effector and immunosuppressive cells upon antigenic stimulation. This study investigated the effects of T. cordifolia on different T cell subsets and found that it inhibits the differentiation and proliferation of Th17 cells via the JAK-STAT signaling pathway. It also showed inhibitory effects on Th1 cells and iTreg cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Richa Sharma, Rahul Sharma, Ragini Raj Singh, Asha Kumari
Summary: Industrial effluent containing dye is a significant source of water contamination. Tinospora cordifolia stem extract can be used to synthesize zinc oxide nanoparticles for the environmentally friendly remediation of wastewater and biomedical applications. These nanoparticles demonstrate photocatalytic efficiency in degrading dye and also possess antimicrobial and antifungal properties.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Plant Sciences
Priyanka Tiwari, Syed Afroz Ali, Bhupendra Puri, Anoop Kumar, Ashok Kumar Datusalia
Summary: This study aims to explore the immunoadjuvant potential of Tinospora cordifolia extract as a response to the Japanese encephalitis vaccine. Through network pharmacology and in vivo experiments, it is shown that preconditioning with the extract can enhance cell-mediated and humoral immunity. The combination of these approaches demonstrates the immunoadjuvant potential of Tinospora cordifolia in response to the vaccine.
Article
Chemistry, Physical
K. Parvathalu, K. Rajitha, B. Chandrashekar, K. Sathvik, K. Pranay Bhasker, B. Sreenivas, M. Pritam, P. Pushpalatha, K. Moses, P. Bala Bhaskar
Summary: Copper nanoparticles (Cu-NPs) were synthesized using Tinospora Cordifolia (TC) aqueous leaf extract as a reducing and stabilizing agent, and their potential for dye degradation was investigated.
Article
Green & Sustainable Science & Technology
K. Vidhya Thomas, K. Joby Thomas, P. Vinod Rapheal, A. S. Sabu, K. Ragi, Reeja Johnson
Summary: The study evaluated the inhibiting capacity of Tinospora cordifolia extract on mild steel in HCl and H2SO4 solutions using physicochemical and electrochemical techniques, along with statistical tools such as response surface methodology and the Box-Behnken design. Experimental results showed high inhibition power of TCE, confirmed by surface analysis, quantum chemical calculations, weight loss measurements, and electrochemical impedance spectroscopy. The study indicated the potential of TCE as an environment-friendly inhibitor for corrosion protection in acid media.
MATERIALS TODAY SUSTAINABILITY
(2021)
Article
Food Science & Technology
Nitin Kumar, Jatindra K. Sahu, Ankur Kumar, Satyanarayan Naik
Summary: This study aimed to optimize the preparation of functional yoghurt enriched with Tinospora cordifolia (giloy) stem extract and investigate the changes in its properties. The experimental results showed that giloy stem extract and total soluble solid had the greatest influence on the various indicators of functional yoghurt. Numerical optimization revealed the optimal combination of giloy stem extract, total soluble solid, and incubation temperature. This study developed a functional yoghurt with high antioxidant activities and improved texture and overall desirability. These results have important implications for scaling up production.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Chemistry, Multidisciplinary
Is Fatimah, Gani Purwiandono, Muhammad Husnu Jauhari, Annabel Audita Aisyah Putri Maharani, Suresh Sagadevan, Won-Chun Oh, Ruey-an Doong
Summary: SnO2 nanoparticles were synthesized using Tinospora cordifolia stem extract, and the effects of extract concentration and ultrasound irradiation on chemical properties were studied. The results showed that higher extract concentration resulted in larger particle size and polymorphic forms, while ultrasound-assisted reduction produced smaller particles. The optical properties were correlated with particle size.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Puja Das, Dipanwita Mitra, Kuladip Jana, Debidas Ghosh
Summary: This study emphasizes the effects of Tinospora cordifolia extract on sperm and reproductive tissues, showing its potential as a spermicide and its specific effects on reproductive tissues, which may contribute to the development of male contraceptives.
REPRODUCTIVE SCIENCES
(2023)
Article
Chemistry, Physical
Shankargouda Patil
Summary: Tinospora cordifolia extract (TcE) demonstrated significant antifibrotic activity by reducing the expression of fibrotic genes and increasing the expression of antifibrotic genes in oral keratinocytes. However, it had varied effects on different genes, warranting further studies to determine the exact mechanism of antifibrotic activity and its potential clinical applications.
Article
Biochemistry & Molecular Biology
Hareram Birla, Chetan Keswani, Saumitra Sen Singh, Walia Zahra, Hagera Dilnashin, Aaina Singh Rathore, Richa Singh, Monika Rajput, Priyanka Keshri, Surya Pratap Singh
Summary: This study investigated the neuroprotective molecular mechanism of Tinospora cordifolia in a rotenone-intoxicated mouse model using a proteomics approach, identifying new therapeutic targets and demonstrating that Tc can exert therapeutic effects by regulating multiple pathways resulting in neuroprotection.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Jorige Archana, Akula Annapurna, Panuganti Devayani
Summary: The study aimed to investigate the protective role of Tinospora cordifolia extract in STZ-induced neurotoxicity and explore the mechanisms responsible for attenuating neuropathic pain. The results showed that treatment with Tinospora cordifolia leaf extract significantly relieved thermal hyperalgesia and allodynia by increasing antioxidant enzyme levels, decreasing lipid peroxidation, and increasing NGF expression in diabetic rat sciatic nerves.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Acharya Balkrishna, Swati Haldar, Anurag Varshney
Summary: This study conducted a toxicological evaluation of the aqueous extract of Tinospora cordifolia stem (TCWE) in rats. The results showed that TCWE was safe at a dose of up to 1000 mg/kg/day, with no toxic effects observed. This study confirmed the safety of Tinospora cordifolia and provides the basis for future clinical research.
FRONTIERS IN PHARMACOLOGY
(2023)
