Article
Chemistry, Physical
Alexsandra Conceicao Apolinario, Leon Hauschke, Jessica Ribeiro Nunes, Felipe Rebello Lourenco, Luciana Biagini Lopes
Summary: This study utilized a QbD approach to optimize ethosomes for the topical administration of the chemopreventive drug candidate Fenretinide (FENR) for breast cancer. The results showed that different preparation methods of ethosomes had differences in drug delivery and biocompatibility, with the binary systems demonstrating better drug delivery efficiency.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Martina Havlikova, Adam Jugl, Jitka Krouska, Jana Szabova, Ludmila Mravcova, Tereza Venerova, Chien-Hsiang Chang, Miloslav Pekar, Filip Mravec
Summary: High-resolution ultrasound spectroscopy, size and zeta-potential titrations, and isothermal titration calorimetry were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles. The interactions showed a correlation between data from size titration, HR-US, and visual observation. Intensity of interactions and the disaggregation were dependent on the molecular weight of hyaluronan.
Article
Biochemistry & Molecular Biology
Jo Sing Julia Tang, Aline Debrassi Smaczniak, Lucas Tepper, Sophia Rosencrantz, Mina Aleksanyan, Lars Daehne, Ruben R. Rosencrantz
Summary: This study describes the synthesis of bioinspired glycopolymer electrolytes using protecting group free and aqueous-based methods, fabricated as thin films by Layer-by-Layer self-assembly to serve as scaffolds for liposomes. The results demonstrate the stability and integrity of glycopolymer coatings and embedded liposomes within the physiological pH range.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hammad A. Faizi, Annie Tsui, Rumiana Dimova, Petia M. Vlahovska
Summary: This study compares the membrane capacitance, bending rigidity, and shear surface viscosity of giant unilamellar vesicles (GUVs) formed by various commonly used methods. The results show that the bending rigidity values are relatively similar across all methods except for agarose hydration. The capacitance values are similar except for vesicles prepared via PVA gel hydration. Membranes prepared by gel-assisted and phase-transfer methods have higher shear viscosity, likely due to remnants of polymers and oils in the lipid bilayer structure.
Article
Biochemistry & Molecular Biology
Yaxin Zhao, Chao Wang, Bohang Zou, Lin Fu, Shushan Ren, Xiangyu Zhang
Summary: The goal of this study was to explore the potential benefits of Tre-FAV as a prospective antipsoriatic topical delivery system. Tre-FAV was successfully developed and characterised, showing improved drug encapsulation and skin permeability. In vitro and in vivo studies confirmed the superior antipsoriatic properties of Tre-FAV compared to other treatments.
Article
Biochemistry & Molecular Biology
Thuan Thi Duong, Antti Isomaki, Urve Paaver, Ivo Laidmae, Arvo Tonisoo, Tran Thi Hai Yen, Karin Kogermann, Ain Raal, Jyrki Heinamaki, Thi-Minh-Hue Pham
Summary: The study demonstrated that both ethanol-injection and thin-film hydration methods are effective in generating BBR-loaded liposomes with uniform size, high encapsulation efficiency, and modified drug release behavior. These liposomes show promise in enhancing the therapeutic effects of orally administered BBR.
Article
Medical Laboratory Technology
Julio Cesar Monteiro Jr, Anna Laura Yuri Yokomichi, Ana Livia de Carvalho Bovolato, Arthur Oscar Schelp, Sidney Jose Lima Ribeiro, Elenice Deffune, Marli Leite de Moraes
Summary: Alzheimer's disease (AD) is a common form of dementia and early diagnosis through non-invasive methods is in high demand. This study successfully detected natural autoantibodies against A beta 40 in plasma using liposomes and immunomagnetic beads, along with the CV detection method.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Chengshou Zhang, Quanshi Guo, Zongrui Tong, Silong Chen, Zhengwei Mao, Yibo Yu
Summary: Near-infrared light-triggered photothermal therapy is considered an attractive noninvasive treatment for posterior capsular opacification (PCO) in cataract patients. Researchers have fabricated a new type of intraocular lens (IOL) with excellent biocompatibility, stability, and photothermal conversion property. The effectiveness of the IOL in preventing PCO has been demonstrated in in vitro and in vivo experiments.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Shouyi Sun, Shuang Yi, Jinjin Li, Zhengmao Ding, Wei Song, Jianbin Luo
Summary: The use of lithium citrate in ethylene glycol as a lubricating additive has been found to achieve a superlubricity state with a coefficient of friction of 0.002 for an a-C film. This reduces the wear rate by 98.3% compared to lubrication with ethylene glycol alone. Friction promotes the chemisorption of lithium citrate molecules, forming robust tribochemical films that prevent direct contact between the friction pair, resulting in minimal wear.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Medicinal
Prashant K. Deshmukh, Rakesh E. Mutha, Sanjay J. Surana
Summary: The study reports the development of chrysin liposomes (CLPs) using chitosan/lecithin to protect chrysin and enhance its therapeutic benefits. The results showed that the CLPs had suitable particle size and stability, improving the solubility and bioavailability of chrysin.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Engineering, Chemical
Florina Miere (Groza), Simona Ioana Vicas, Adrian Vasile Timar, Mariana Ganea, Mihaela Zdrinca, Simona Cavalu, Luminita Fritea, Laura Vicas, Mariana Muresan, Annamaria Pallag, Luciana Dobjanschi
Summary: This study successfully obtained giant liposomes by using two different phospholipids and encapsulating Stellaria media (L.) Vill. extract in them. The PCE liposomes had a larger diameter while the PSE liposomes showed higher encapsulation efficiency.
Article
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Muhammad H. Sultan, Osama Ali Madkhali, Shahd Hassan Alsabei, Asia Abdullah Alessa
Summary: This study focuses on developing long-lasting liposomes using polyethylene glycol (PEG) with different molecular weights to improve the solubility and continuous release of camptothecin (CPT). The stealth liposomes prepared with PEG(5000) showed higher encapsulation efficiency, prolonged drug release, and better stability at refrigeration temperature compared to conventional liposomes. The pharmacokinetic parameters of stealth liposomes containing PEG(2000) and PEG(5000) also significantly differed from conventional liposomes, indicating altered tissue distribution.
Article
Polymer Science
Prashant Kesharwani, Shadab Md, Nabil A. Alhakamy, Khaled M. Hosny, Anzarul Haque
Summary: Azacitidine-loaded liposomes (AZA-LIPO) were successfully formulated and optimized for breast cancer chemotherapy, showing small particle size, high entrapment efficiency, and drug loading. In vitro drug release study demonstrated sustained release behavior and enhanced cellular uptake and cytotoxicity in MCF-7 cells compared to free drug.
Article
Chemistry, Physical
Da Zhou, Aimin Ge, Toshiki Kogina, Ken-ichi Inoue, Yan-Xia Chen, Shen Ye
Summary: This study investigates the interfacial structures of a Nafion/graphene composite under different humid environments using SFG vibrational spectroscopy. The results show that the Nafion thin film forms a lamellar structure on the graphene surface, with a similar orientation to that of the free Nafion/air interface. The buried Nafion/graphene interface has distinct structural differences compared to hydrophilic substrate surfaces such as fused quartz and calcium fluoride, which significantly affect water adsorption behaviors at the interface.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Biochemistry & Molecular Biology
Dorina Gabriella Dobo, Zsofia Nemeth, Bence Sipos, Martin Cseh, Edina Pallagi, Daniel Berkesi, Gabor Kozma, Zoltan Konya, Ildiko Csoka
Summary: This study aimed to produce thermosensitive liposomes using the quality by design concept and investigated the parameters affecting the quality of the liposomal product. The findings showed that the thermal properties of liposomes are influenced by the types and ratios of lipids used.
