Article
Clinical Neurology
Maarten Lequin, Floris Groenendaal, Jeroen Dudink, Paul Govaert
Summary: Diagnosing kernicterus in the acute phase is challenging, as the conventional T1w sequence may show high signal intensity due to early myelination. However, the SWI sequence appears to be more sensitive and reliable for detecting damage in the globus pallidum area.
Article
Clinical Neurology
Thomas Pfefferkorn, Joachim Roether, Bernd Eckert, Hendrik Janssen
Summary: In this study, typical clinical and imaging features of brainstem encephalitis in neuroborreliosis were identified through a retrospective observational analysis with reference to a historical case from 2009. The patients exhibited prolonged clinical course with unspecific symptoms like wasting, fatigue, and headache, along with irregularly observed brainstem signs and symmetrical brainstem alterations on MRI, forming an image resembling a Philippine tarsier in FLAIR imaging. A subset of neuroborreliosis patients were found to develop brainstem encephalitis with distinct clinical course and MRI findings.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Claire L. MacIver, Chantal M. W. Tax, Derek K. Jones, Kathryn J. Peall
Summary: This review summarizes the methodological approaches used in structural brain imaging studies of dystonia cohorts and identifies commonly implicated pathways, networks, or regions in pathogenesis. The findings suggest microstructural brain changes in individuals diagnosed with dystonia, although the underlying nature of these changes remains unknown. The use of techniques such as multiple diffusion weightings or multi-exponential relaxometry has the potential to enhance understanding of these differences.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medical Laboratory Technology
David H. Thomas, Janet Warner, Graham R. D. Jones, Jason Z. Y. Chung, David J. Macey, Antonella Screnci, Joshua B. Ryan
Summary: The interlaboratory variability of total serum bilirubin (TSB) results in newborns was assessed, revealing significant differences between laboratories, mainly due to a lack of calibration standardization. This may have implications for healthcare resource use and potentially affect the neurodevelopment of infants. Intervention is needed at multiple levels.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Clinical Neurology
Eleonora Mauri, Daniela Piga, Alessandra Govoni, Roberta Brusa, Serena Pagliarani, Michela Ripolone, Robertino Dilena, Claudia Cinnante, Monica Sciacco, Denise Cassandrini, Vincenzo Nigro, Nereo Bresolin, Stefania Corti, Giacomo P. Comi, Francesca Magri
Summary: RYR1-RCM is the most common subgroup among congenital myopathies, presenting with high clinical heterogeneity. Early comprehensive characterization and genetic analysis are crucial for diagnosis and prompt medical management.
FRONTIERS IN NEUROLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hee Kyung Kim, Shital Parikh
Summary: Patellofemoral instability (PFI) is a common issue in pediatric knee injuries, resulting from an imbalance in the dynamic relationship between the patella and the femoral trochlear groove. Various factors, such as anatomical variants and altered biomechanics, contribute to PFI. Treatment aims to restore normal patellofemoral dynamics and prevent persistent PFI.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
H. Nursun Ozcan, Ozlem Ozkale Yavuz, Saniye Ekinci, Berna Oguz, Tezer Kutluk, Mithat Haliloglu
Summary: Gastrointestinal tract tumors are rare in children and adolescents, and are often misdiagnosed. Lymphoma is the most common GI tract tumor, frequently found in the ileum and ileocecal area. GI tract tumors typically manifest as large heterogeneous masses. Thickening of the walls in gastric and colonic tumors usually indicates GI tract tumors. Computed tomography and magnetic resonance imaging are used for accurate diagnosis and management in clinically suspected cases. Radiologists need to be aware of the most common tumors and their locations.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria El Homsi, Karem Gharzeddine, Jordan Cuevas, Julio Arevalo-Perez, Karim Rebeiz, Nabil J. Khoury, Hicham Moukaddam
Summary: The study highlights the lack of consensus and clarity in the classification system of lumbar arachnoiditis, with high interreader agreement only among experienced readers when assessing the presence of synechia.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Endocrinology & Metabolism
Daniela Fava, Andrea Calandrino, Maria Grazia Calevo, Anna Elsa Maria Allegri, Flavia Napoli, Roberto Gastaldi, Giuseppa Patti, Emilio Casalini, Marta Bassi, Andrea Accogli, Abdel Razaq Ahmad A. Alyasin, Antonia Ramaglia, Andrea Rossi, Mohamad Maghnie, Giovanni Morana, Natascia Di Iorgi
Summary: The study investigated the presence of brain abnormalities in girls diagnosed with central precocious puberty (CPP) and explored the relationship between maternal factors, age at diagnosis, clinical signs and symptoms, hormonal profiles, and neuroimaging findings. The results showed that less than half of the girls had a normal brain MRI, and a few had significant intracranial lesions after the age of 6, even without neurological signs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biology
Botond Antal, Liam P. McMahon, Syed Fahad Sultan, Andrew Lithen, Deborah J. Wexler, Bradford Dickerson, Eva-Maria Ratai, Lilianne R. Mujica-Parodi
Summary: This study analyzed neuroimaging and cognitive data from a large cohort of individuals with type 2 diabetes mellitus (T2DM) and healthy controls. The findings show that T2DM is associated with significant cognitive deficits and structural and functional brain changes, with overlap with aging effects. The duration of the disease is linked to more severe neurodegeneration. Treatment with metformin does not improve neurocognitive outcomes.
Article
Clinical Neurology
Johannes T. Reiter, Bastian David, Selma Enders, Conrad C. Prillwitz, Tobias Bauer, Deniz Atalay, Anna Tietze, Angela M. Kaindl, Vera Keil, Alexander Radbruch, Bernd Weber, Albert J. Becker, Christian E. Elger, Rainer Surges, Theodor Rueber
Summary: Using MRI and diffusion tensor imaging, this study found bilateral cerebellar atrophy and predominantly ipsilesional mesencephalic atrophy in patients with RE. Morphometric asymmetry indices showed varying patterns of asymmetry, with strong correlation between cerebellar morphometry and FLAIR intensity asymmetry. Spatial independent component analysis revealed bilateral and ipsi/contralesional atrophy components in patients with RE.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Karen-Cecilie Kortenbach, Lars Boesen, Vibeke Logager, Henrik S. Thomsen
Summary: After a low-suspicion biparametric magnetic resonance imaging result, the 5-year risk of being diagnosed with significant prostate cancer was found to be 1.7% in this study population.
Review
Cell Biology
Abida Islam Pranty, Sara Shumka, James Adjaye
Summary: The molecular mechanisms of bilirubin-induced neurological damage remain largely unknown. In order to better understand the effects of bilirubin on the liver and developing human brain, it is crucial to establish a physiologically recapitulating in vitro model. Stem-cell-derived 3D brain organoids offer a promising platform for research, drug screening, and therapeutic strategies due to their similarity to the human brain system.
Review
Health Care Sciences & Services
Benedetta Gui, Salvatore Persiani, Maura Micco, Vincenza Pignatelli, Elena Rodolfino, Giacomo Avesani, Valerio Di Paola, Camilla Panico, Luca Russo, Simona Maria Fragomeni, Giorgia Garganese, Luca Tagliaferri, Giovanni Scambia, Riccardo Manfredi
Summary: MRI plays a crucial role in staging locally advanced vulvar cancer, providing detailed information on tumor extension and aiding in accurate staging. It is essential to optimize the imaging protocol and technique to ensure correct staging and provide necessary information for clinicians.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Behavioral Sciences
Philip Deming, Mickela Heilicher, Michael Koenigs
Summary: Through a systematic review of MRI studies, this research found that the relationship between psychopathy and amygdala structure and function is mostly null, reduced amygdala activity is more common in studies with low statistical power, and the peak coordinates of reduced amygdala activity do not primarily fall within the anatomical bounds of the amygdala.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
