Review
Microbiology
Bela Kocsis, Daniel Gulyas, Dora Szabo
Summary: This review summarizes the characteristics and mechanisms of drug resistance of high-risk Pseudomonas aeruginosa clones from confirmed outbreaks and whole-genome sequence data. Common features such as beta-lactamases production and distribution of metallo-beta-lactamases in different STs are highlighted. The resistance to colistin among P. aeruginosa clones is less developed compared to other mechanisms, while transferable quinolone resistance determinants are frequently reported, with aac(6 ')-Ib-cr variant being the most commonly found.
Article
Biochemistry & Molecular Biology
Orfa Ines Contreras Martinez, Alberto Angulo Ortiz, Gilmar Santafe Patino
Summary: The plant compound ISO has antibacterial and antibiofilm potential against nosocomial pathogens and could serve as an adjuvant in the control of these pathogens.
Article
Multidisciplinary Sciences
Jiarong Zhou, Nishta Krishnan, Zhongyuan Guo, Christian J. Ventura, Maya Holay, Qiangzhe Zhang, Xiaoli Wei, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: This study investigates the effectiveness of a biomimetic nanotoxoid vaccine in protecting immunodeficient animals from Pseudomonas aeruginosa infection. The nanotoxoids utilize a macrophage membrane coating to sequester and present bacterial virulence factors, providing rapid and long-lasting immunity. The nanovaccine can be administered through multiple routes and effectively protects against lethal infections in pneumonia and septicemia models.
Article
Engineering, Environmental
Tayebeh Hasanvand, Mohsen Mohammadi, Foad Abdollahpour, Bahram Kamarehie, Ali Jafari, Afshin Ghaderpoori, Mohammad Amin Karami
Summary: The study demonstrated that carvacrol showed stronger antibacterial effects against selected bacteria compared to glutaraldehyde. The optimal time and concentration of carvacrol+ethanol against hospital isolates of P. aeruginosa and S. aureus were determined. Carvacrol, as a herbal and natural agent, may serve as a suitable alternative to glutaraldehyde for hospital equipment sterilization.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2021)
Article
Microbiology
Zeina A. Kanafani, Ahmad Sleiman, Jim Abi Frem, George Doumat, Amal Gharamti, Bassam El Hafi, Michel Doumith, Majed F. AlGhoribi, Souha S. Kanj, George F. Araj, Ghassan M. Matar, Antoine G. Abou Fayad
Summary: This study aimed to explore the differential activity of ciprofloxacin and levofloxacin on the selection of resistance among P. aeruginosa isolates. The results showed that the induced mutants against ciprofloxacin and levofloxacin had higher fitness cost compared to their parental isolates.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Mehdi Bakht, Safar Ali Alizadeh, Sara Rahimi, Raana Kazemzadeh Anari, Mohammad Rostamani, Amir Javadi, Amir Peymani, Seyed Mahmoud Amin Marashi, Farhad Nikkhahi
Summary: This study evaluated the susceptibility of Pseudomonas aeruginosa to five commonly used Hospital disinfectants, finding that sodium hypochlorite and ethanol showed the highest and lowest effectiveness, respectively. The addition of EDTA increased the effectiveness of the disinfectants. Exposure to sub-inhibitory concentrations of sodium hypochlorite resulted in resistance to some antibiotics in P. aeruginosa.
Review
Public, Environmental & Occupational Health
Lijuan Guo, Hui Xu, Zhigang Yue
Summary: This study investigated the resistance profiles of wound-isolated Pseudomonas aeruginosa to antimicrobial agents among Chinese burn patients. The results showed an increasing trend of resistance and the highest resistance to gentamicin. Effective stewardship programs should be established to optimize treatment options for burn patients.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jingwen Lyu, Huimin Chen, Jinwei Bao, Suling Liu, Yiling Chen, Xuxia Cui, Caixia Guo, Bing Gu, Lu Li
Summary: The study analysed the distribution of antimicrobial drug resistance (AMR) among Pseudomonas aeruginosa isolates from Guangdong Provincial People's Hospital from 2017 to 2021 and the impact of the COVID-19 outbreak on changes in the clinical distribution and drug resistance rate of P. aeruginosa. The results showed an increasing trend in the detection rate of clinically resistant P. aeruginosa strains and a rise in multidrug-resistant (MDR) strains. However, the growth of MDR bacteria slowed after the outbreak of COVID-19, likely due to strict epidemic prevention and control measures in China. The study highlights the importance of rational antibiotic use and prevention and control measures in reducing drug resistance and improving patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Ana Candela, Manuel J. Arroyo, Maria Sanchez-Cueto, Mercedes Marin, Emilia Cercenado, Gema Mendez, Patricia Munoz, Luis Mancera, David Rodriguez-Temporal, Belen Rodriguez-Sanchez
Summary: The study evaluated matrix-assisted laser desorption ionization-iime of flight mass spectrometry (MALDI-TOF MS) and Fourier-transform infrared spectroscopy (FTIR-S) as diagnostic alternatives for the detection of Pseudomonas aeruginosa sequence type (ST) 175 isolates involved in a hospital outbreak. The results showed that the combination of these two technologies, along with machine learning tools, can effectively monitor high-risk clones and isolates in nosocomial outbreaks.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Microbiology
Carl-Johan Fraenkel, Gustaf Starlander, Eva Tano, Susanne Suetterlin, Asa Melhus
Summary: The first outbreak of a multidrug-resistant Pseudomonas aeruginosa strain carrying Verona integron-borne metallo-β-lactamase (VIM)-2 occurred in two neighbouring hospitals in Sweden. The outbreak was caused by a clonal strain belonging to the high-risk clonal complex 111 and was only susceptible to gentamicin and colistin. The waterborne transmission of P. aeruginosa can be reduced by implementing proactive control measures to limit bacterial load in sinks.
Article
Microbiology
Yanyan Hu, Congcong Liu, Qi Wang, Yu Zeng, Qiaoling Sun, Linbin Shu, Jiayue Lu, Jiacang Cai, Shaolin Wang, Rong Zhang, Zuowei Wu
Summary: Pseudomonas aeruginosa is a major opportunistic pathogen causing healthcare-associated infections, with carbapenem-resistant strains on the rise. A highly resistant CRPA clone (ST463) has emerged recently, carrying virulence-related genes and the plasmid-borne carbapenem-resistant gene bla(KPC-2).
Article
Public, Environmental & Occupational Health
P. Bidet, A. Birgy, B. Brethon, J. H. Dalle, P. Mariani-Kurkdjian, C. Courroux, A. Monjault, M. Gits-Muselli, S. Bonacorsi
Summary: This study designed and evaluated a rapid and simple typing method for Pseudomonas aeruginosa compared to whole genome sequencing (WGS). The simplified and inexpensive method called MLVA could exclude most unrelated isolates in a short time and focus investigations on a small number of cases. Sequential use of both methods was identified as the optimal strategy to investigate clustered cases of P. aeruginosa infections.
JOURNAL OF HOSPITAL INFECTION
(2022)
Review
Microbiology
Sang Phan, Cafrey He Feng, Raymond Huang, Zeng X. Lee, Yer Moua, Olivia J. Phung, Justin R. Lenhard
Summary: Pseudomonas aeruginosa is commonly found in chronic wound infections worldwide, except in South America, where it is less prevalent. It is the second most common organism in each continent, with Staphylococcus aureus being the most abundant pathogen overall. In Southeast Asia nations including India and Malaysia, P. aeruginosa is the most frequently isolated organism in chronic wound infections. The presence of P. aeruginosa in diabetic foot infections is lower in North America, Europe, and Africa compared to other types of chronic wound infections. The isolation of P. aeruginosa using the Levine wound swab technique may not be a reliable predictor of the patient's clinical course.
Article
Infectious Diseases
Ziv Dadon, Eli Ben-Chetrit, Ofer Benjaminov, Louay Taha, Yonit Wiener-Well, Daniel Belman, Phillip D. Levin
Summary: The study assessed the role of CT scans in cross-transmission of CRAB between hospitalized patients and found that undergoing a CT scan within 6 hours of a CRAB-positive patient's scan was an independent predictor of CRAB acquisition, approximately tripling the risk.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)