Article
Multidisciplinary Sciences
Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Amalia Eisenberg, John Rhee, Walavan Sivakumar, Howard Krauss, Neil Martin, Chester Griffiths, Garni Barkhoudarian, Daniel F. Kellyid
Summary: Background: Meningioma surgery has evolved over the last 20 years with increased use of minimally invasive approaches. This study retrospectively analyzed the outcomes of keyhole transcranial and endoscopic endonasal meningioma removal in comparison to traditional skull base approaches. The results showed comparable resection rates, low complication rates, short hospitalizations, and high 90-day performance scores.
Letter
Oncology
Bernhard Horsthemke
Summary: Modern epigenetics has rapidly developed in the past 40 years, but has also been accompanied by misconceptions and methodological shortcomings. One misconception is that chromatin modifications are an independent layer of gene regulation directly responsive to the environment, while in reality, environmental factors mainly affect gene expression through transcription factors and signaling cascades. Methodological shortcomings, such as insufficient consideration of genetic variation and cell mixture distribution, also need to be addressed.
CLINICAL EPIGENETICS
(2022)
Review
Biochemistry & Molecular Biology
Francesco Cavallieri, Valentina Fioravanti, Francesco Bove, Eleonora Del Prete, Sara Meoni, Sara Grisanti, Marialuisa Zedde, Rosario Pascarella, Elena Moro, Franco Valzania
Summary: This review summarizes the clinical, biological, and neuroimaging features of COVID-19-related parkinsonism and discusses the possible pathophysiological mechanisms. The appearance of parkinsonism during or immediately after COVID-19 infection is a very rare event. Different mechanisms, including vascular damage and neuroinflammation, may play a role, and further long-term observational studies are needed to evaluate the association between COVID-19 infection and the development of Parkinson's Disease.
Review
Oncology
Rafael Rios-Tamayo, Bruno Paiva, Juan Jose Lahuerta, Joaquin Martinez Lopez, Rafael F. Duarte
Summary: Monoclonal gammopathy of clinical significance (MGCS) refers to a complex and heterogeneous group of nonmalignant monoclonal gammopathies. Patients in this group have a small clone and experience symptoms related to the clone or monoclonal protein through various mechanisms. This field is evolving and challenging, with multiorgan involvement being a key clinical feature.
Review
Critical Care Medicine
Jayshil J. Patel, Aileen Hill, Zheng-Yii Lee, Daren K. Heyland, Christian Stoppe
Summary: This article provides a concise review on how to read and critically appraise a systematic review. A systematic review is a transparent and reproducible summary of research, and its conclusions are only credible and reliable if the process and included studies are of high quality. Applying evidence from a systematic review to patient care requires considering factors such as direct applicability, consideration of all important outcomes, and balancing benefits with potential harms and costs.
CRITICAL CARE MEDICINE
(2022)
Article
Hospitality, Leisure, Sport & Tourism
David Tod, Andrew Booth, Brett Smith
Summary: This article aims to define critical appraisal, discuss its benefits, address conceptual issues affecting the adequacy of appraisal, and provide procedures for reviewers to conduct critical appraisals. Critical appraisal involves assessing a study's trustworthiness or methodological rigor to determine the confidence in its findings. Reviewers need to differentiate between quality and bias, understand total quality scores, weigh the pros and cons of standardized checklists, consider the experimental hierarchy of evidence, distinguish between appraisal tools and reporting standards, and handle the challenges of appraising qualitative research.
INTERNATIONAL REVIEW OF SPORT AND EXERCISE PSYCHOLOGY
(2022)
Review
Immunology
Cristian Papara, Christian M. Karsten, Hideyuki Ujiie, Enno Schmidt, Leon F. Schmidt-Jimenez, Adrian Baican, Patricia C. Freire, Kentaro Izumi, Katja Bieber, Matthias Peipp, Admar Verschoor, Ralf J. Ludwig, Joerg Koehl, Detlef Zillikens, Christoph M. Hammers
Summary: Pemphigoid diseases are chronic inflammatory skin diseases characterized by blistering and autoantibodies. Complement plays an important role in these diseases, but recent studies have shown that inflammation can occur independently of complement.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Jose M. M. Senovilla
Summary: This article provides a brief overview of the main ideas behind singularity theorems and evaluates their hypotheses and implications. It dispels common misconceptions and discusses the nature of space-time extensions and singularities inside black holes.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Review
Environmental Sciences
Qiao Wang, Xiting Gu, Suqin Tang, Arif Mohammad, Devendra Narain Singh, Haijian Xie, Yun Chen, Xinru Zuo, Zhilin Sun
Summary: Landfill gas emission poses a threat to the atmosphere and human health. The performance of landfill covers in reducing these emissions is still uncertain. Further research is needed to improve the effectiveness of modified soil in mitigating gas transport. The study of unconventional contaminants and the interaction between different gas species in multi-component gas transport also requires more attention.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Nutrition & Dietetics
Elena Massimino, Anna Paola Amoroso, Roberta Lupoli, Alessandro Rossi, Brunella Capaldo
Summary: Glycogen storage disease Type III (GSD III) is a genetic disorder characterized by reduced glucose availability and abnormal glycogen accumulation. The impact of dietary lipid manipulations on GSD III is still debated. A case study showed that a low-carbohydrate, high-fat, high-protein diet improved muscle and heart damage biomarkers in a GSD IIIa patient without adverse effects on glucose and lipid profiles. This dietary approach could be beneficial for preventing/minimizing organ damage in GSD III patients.
FRONTIERS IN NUTRITION
(2023)
Review
Behavioral Sciences
Iris Unterberger, Eugen Trinka, Gerhard Ransmayr, Christoph Scherfler, Gerhard Bauer
Summary: This paper critically reviews terms and concepts of ictal language alterations in epilepsy patients. Through literature search and analysis, it summarizes the heterogeneity of language symptoms and the importance of diagnostic techniques in language-related seizure symptoms.
EPILEPSY & BEHAVIOR
(2021)
Review
Chemistry, Analytical
Maria Murcia-Morales, Horacio Heinzen, Piedad Parrilla-Vazquez, Maria del Mar Gomez-Ramos, Amadeo R. Fernandez-Alba
Summary: The article discusses the methodology and significance of pesticide analysis in bee-related matrices. It presents two different approaches, including the evaluation of monitoring studies conducted from 2011 to 2021 and the revision of current legislations regarding chemicals in apicultural matrices. The findings highlight the need for a clear definition of each apicultural matrix and the presence of widespread agricultural pesticides, as well as the emergence of new chemicals in the field of agriculture and apiculture.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Oncology
Florence Bihain, Claire Nomine-Criqui, Philippe Guerci, Stephane Gasman, Marc Klein, Laurent Brunaud
Summary: The management of pheochromocytomas has significantly evolved in the past 50 years with the emergence of new technologies, but current clinical guidelines are still based on early experiences and may need revision.
Article
Clinical Neurology
Dennis Yeow, Matthew Katz, Robert Henderson, Sandhir Prasad, Russell Denman, Stefan Blum, Mark Davis, Thomas Robertson, Pamela McCombe
Summary: The DES gene encodes desmin, an important protein in skeletal, cardiac, and smooth muscle. Mutations in the DES gene can lead to a range of muscular disorders known as desminopathies. We present three cases of desminopathy that demonstrate the phenotypic diversity of this disorder, and discuss factors that contribute to clinical differences between patients with different desmin variants and within families.
FRONTIERS IN NEUROLOGY
(2023)
Review
Oncology
Akanksha Behl, Zahoor A. Wani, Nagendra Nath Das, Virinder S. Parmar, Christophe Len, Shashwat Malhotra, Anil K. Chhillar
Summary: In breast cancer, monoclonal antibodies (mAbs) have multifunctional roles including targeting cancer cells, delivering therapeutic drugs, inhibiting cell growth, and blocking immune system inhibitors. Although mAbs have been successful in treating HER2-positive breast cancer, their potential for other types of breast cancer, especially triple negative breast cancer, has not been explored extensively. The antigen specificity of mAbs has been improved with the development of bispecific and trispecific mAbs, opening new doors for targeted efficacy. However, mAbs treatment can cause side effects such as fever, fatigue, headache, and nausea. Understanding the pros and cons of mAbs, this review explores their current and future potential for the diagnosis and treatment of breast cancer.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
