期刊
INDIAN JOURNAL OF MICROBIOLOGY
卷 53, 期 2, 页码 208-213出版社
SPRINGER
DOI: 10.1007/s12088-012-0333-4
关键词
Cardiospermum halicacabum; FT-IR; GC-MS; Antimicrobial activity; Multidrug resistant strains
资金
- University Grants Commission, New Delhi, India
- Department of Science and Technology (DST)
The present study was carried out to analyze chemical constituents and antibacterial activity of ethanolic leaf extract of Cardiospermum halicacabum (ECH). The FT-IR spectrum confirmed the presence of alcohols, phenols, alkanes, alkynes, aliphatic ester and flavonoids in ECH. The GC-MS analysis revealed that ECH contained about twenty four compounds. The major chemical compounds identified were cyclohexane-1, 4, 5-triol-3-one-1-carboxylic acid, benzene acetic acid, caryophyllene, phytol and neophytadiene. The ECH was screened for its antibacterial activity against different bacterial strains and anti fungal activity against Candida albicans by agar well diffusion and minimum inhibitory concentration (MIC) assay. ECH exhibited antibacterial and antifungal activity. All the tested bacterial strains showed MIC values ranging from 80 to 125 mu g of extract/ml and C. albicans showed 190 mu g of extract/ml as a MIC. The maximum activity ECH was observed against human pathogen Staphylococcus aureus followed by Escherichia coli and the fish pathogen Aeromonas hydrophila. ECH exhibited moderate activity against some of the tested multidrug resistant strains.
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