Review
Infectious Diseases
Siyuan Ma, Yali Gong, Xiaoqiang Luo, Yuan Peng, Cheng Zhang, Xiaorong Zhang, Xiaohong Hu, Peng Tang, Zhiqiang Yuan, Gaoxing Luo, Haisheng Li
Summary: The prevalence of E. meningoseptica infections in mainland China has been increasing, along with multidrug resistance and high mortality rates. Inappropriate antibiotic treatment and the use of central venous catheters are important risk factors that should be addressed.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Liangcai Xu, Bo Peng, Yuxiang He, Yujun Cui, Qinghua Hu, Yarong Wu, Hongbiao Chen, Xiaofeng Zhou, Lili Chen, Min Jiang, Le Zuo, Qiongcheng Chen, Shuang Wu, Yang Liu, Yanming Qin, Xiaolu Shi
Summary: During the COVID-19 pandemic, three fever epidemic clusters unrelated to COVID-19 occurred in Shenzhen, China. This study investigated and characterized the Elizabethkingia anophelis contaminant isolated from throat and anal swab samples of patients. The study found that the patients' samples and blank samples were positive for E. anophelis, but the patients were not infected with this bacterium, and the causative agent for the fevers remains unidentified.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Shaohua Hu, Yan Lv, Hao Xu, Beiwen Zheng, Yonghong Xiao
Summary: This study investigated the association between antimicrobial resistance and biofilm formation ability in Elizabethkingia anophelis isolated from hospitalized patients in China. The results showed high resistance to current antibiotics among clinical E. anophelis isolates, with all strains being multidrug-resistant and 20 being extensively drug-resistant. The isolates also exhibited the ability to form biofilm, with a positive correlation between biofilm formation and antibiotic resistance. The study highlights the importance of understanding the resistance mechanisms and biofilm formation in E. anophelis infections for improving therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Shaohua Hu, Yingying Chen, Hao Xu, Jing Chen, Shaojun Hu, Xiaohua Meng, Shujun Ni, Yonghong Xiao, Beiwen Zheng
Summary: This study comprehensively analyzes the global distribution, evolutionary history, and transmission networks of E. meningoseptica. The emerging bacteria are found in Asia, Europe, and North America, and show genetic diversity. The most likely source of E. meningoseptica is the United States, and the pathogen can spread within hospitals and across borders. The observation of minor variations in resistance genotypes and virulence genes support the inherent resistance and pathogenicity of E. meningoseptica. Minocycline and doxycycline demonstrate potent antimicrobial activity against this pathogen.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Madeeha Subhan Waleed, Vineeth Amba, Ashok Abraham Varughese, Radhika Pathalapati
Summary: Elizabethkingia meningoseptica is a rare gram-negative aerobic organism with yellow pigments, often resistant to most antibiotics. Early diagnosis and treatment are crucial for better patient outcomes, highlighting the importance of adequate knowledge among physicians and microbiologists regarding this infection and its treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Microbiology
Yu-Lin Lee, Kuan-Ming Liu, Hui-Lan Chang, Yi-Ci Liao, Jen-Shiou Lin, Fang-Yen Kung, Cheng-Mao Ho, Kai-Hsiang Lin, Ying-Tsong Chen
Summary: The incidence of Elizabethkingia anophelis bacteremia has increased significantly in Changhua Christian Hospital since 2013. A specific lineage of E. anophelis strains with unique genomic features has emerged and shown resistance to antibiotics. This finding has important implications for further research and developing effective treatment strategies.
MICROBIOLOGY SPECTRUM
(2022)
Review
Microbiology
Asdren Zajmi, Jeanette Teo, Chew Chieng Yeo
Summary: Elizabethkingia spp. is a pathogenic bacterium that causes various diseases, especially in neonates and immunocompromised patients. Difficulties in accurately identifying the species of this bacterium using traditional methods may lead to an underestimation of the number of cases. The bacterium has an unusual antibiotic resistance pattern, suggesting an intrinsic origin for its multidrug resistance. Preventing and understanding Elizabethkingia spp. infections and limiting its spread is a new challenge.
Article
Biology
Tatjana Kirtikliene, Aiste Mierauskaite, Ilona Razmiene, Nomeda Kuisiene
Summary: The study analyzed multidrug-resistant Acinetobacter spp. isolates from human bloodstream infections in 14 healthcare institutions in Lithuania during 2014, 2016, and 2018. The results indicated potential relatedness of different Acinetobacter spp. isolates and circulation of resistance genes or profiles in different years of the study.
Article
Medicine, General & Internal
Abdul Wasey Hashmi, Muhammad Ahmad, Muhammad Muneeb Israr, Ibtesam e Fajar, Farid Adnan
Summary: This article presents a case of a preterm neonate infected with the gram-negative bacillus Elizabethkingia meningoseptica. The bacteria caused late-onset sepsis in the neonate and were resistant to multiple drugs, but sensitive to vancomycin and ciprofloxacin. The patient completed antibiotic therapy and was discharged, with successful follow-ups.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
A. M. U. B. Mahfuz, Muhammad Nasir Iqbal, Felipe Stambuk Opazo, A. M. Zubair-Bin-Mahfuj
Summary: Antibiotic resistance is a global concern, with Elizabethkingia species like E. anophelis and E. meningoseptica being resistant to multiple antibiotics. Researchers are exploring new antibiotics that target unconventional sites, such as bacterial ribonucleotide reductases. This study evaluates the binding affinities of compounds inhibiting Pseudomonas aeruginosa growth by targeting its ribonucleotide reductase with enzymes from E. anophelis and E. meningoseptica to combat infections in the future.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Medicine, General & Internal
Neetha S. Murthy, Sowmya G. Shivappa, A. Tejashree, Krishna M. V. S. Karthik, R. Deepashree
Summary: Elizabethkingia is a common aerobic bacterium found in both community and hospital settings, while Elizabethkingia meningoseptica is an emerging nosocomial pathogen with the ability to adapt to diverse environments. Prompt diagnosis and early therapeutic intervention are crucial in managing infections caused by this bacterial species. In the reported case of meningitis and septicemia in a newborn, the infant responded well to treatment and was discharged after 7 days of therapy with ciprofloxacin. Treatment protocols guided by accurate laboratory evidence play a key role in preventing unfavorable outcomes when dealing with rare multidrug-resistant opportunistic infections.
JOURNAL OF LABORATORY PHYSICIANS
(2022)
Article
Medicine, General & Internal
Priyadarshini Patro, Padma Das, Phalguni Padhi
Summary: Elizabethkingia meningoseptica is a challenging pathogen causing neonatal meningitis with multidrug resistance. Prompt identification and early appropriate antimicrobial therapy are crucial for successful management of neonatal meningitis caused by this rare pathogen.
JOURNAL OF LABORATORY PHYSICIANS
(2021)
Article
Microbiology
Isin Y. Comba, Audrey N. Schuetz, Anisha Misra, Daniel Z. P. Friedman, Ryan Stevens, Robin Patel, Zane D. Lancaster, Aditya Shah
Summary: Elizabethkingia species showed high rates of susceptibility to minocycline and TMP-SMX. Further studies are needed to investigate the clinical implications of species-level differences in antimicrobial susceptibilities in this genus.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qiang Yang, Zhiming Zheng, Genhai Zhao, Li Wang, Han Wang, XiuMin Ding, Chunxu Jiang, Chu Li, Guoliang Ma, Peng Wang
Summary: In this study, a co-culture system of Elizabethkingia meningoseptica and Escherichia coli was successfully designed to improve the biosynthesis of vitamin K2. The results demonstrate that co-culture engineering can be a beneficial method for strains with restricted molecular modifications in the field of metabolic engineering.
MICROBIAL CELL FACTORIES
(2022)
Article
Infectious Diseases
Srishti Goel, Sandeep Dayanand Jhajra, Sushma Nangia, Ajay Kumar, Debasish Nanda
Summary: Elizabethkingia meningoseptica is a rare cause of sepsis and meningitis in neonates. This study aimed to describe the clinical characteristics and outcome of neonates who developed meningitis secondary to Elizabethkingia meningoseptica infection in India. Seven neonates were identified with meningitis in this study, and lethargy, apnea, seizure, and feeding difficulties were common clinical presentations. The overall mortality rate was 28.5%, and 60% of the survivors developed hydrocephalus. The isolated strains were resistant to commonly used antibiotics. The potential source of infection could not be identified conclusively.
JOURNAL OF GLOBAL INFECTIOUS DISEASES
(2023)
Review
Immunology
G. Vithiya, P. Shunmuga Sundaram
Summary: This case describes a patient who developed infection after percutaneous transluminal coronary angioplasty and subsequently died due to improper treatment, primarily caused by endocarditis caused by M. abscessus.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
Article
Immunology
Pheba Stanley, Nonika Rajkumari, Monika Sivaradjy
Summary: The study aimed to detect the mutation patterns in drug targets in Plasmodium vivax that develop resistance to common antimalarial agents in India. By analyzing 27 Plasmodium vivax isolates, the study found an increase in the proportion of double mutants in pvmdr1 and pvdhfr over time. Cases with double mutant pvmdr1 gene had a prolonged hospital stay compared to those without, indicating reduced clinical response to chloroquine.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
Letter
Immunology
Amnuay Kleebayoon, Viroj Wiwanitkit
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)