Article
Biotechnology & Applied Microbiology
Hye-Rim Kim, Yong-Bin Eom
Summary: This study demonstrates the potential of repurposing auranofin as an antibiotic adjuvant against carbapenemase-producing Acinetobacter baumannii. The synergistic effect of auranofin and doripenem is confirmed, as well as the inhibitory effects of auranofin on biofilms and motility. Auranofin also induces changes in gene expression related to carbapenem resistance.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
A. Nussbaumer-Proell, S. Eberl, E. Kurdina, L. Schmidt, M. Zeitlinger
Summary: This study investigated the in vitro antibiotic activity of meropenem under different distributions of %T > MIC against P. aeruginosa and E. coli. The results showed that dividing the 40%T > MIC into three short periods can reduce antibiotic concentrations to achieve efficient bacterial killing and reduce the emergence of resistance in P. aeruginosa isolates.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Chuanqing Zhong, Yingping Zhou, Jiafang Fu, Xiaoyu Qi, Zhen Wang, Jiaqi Li, Peipei Zhang, Gongli Zong, Guangxiang Cao
Summary: This study found that Pseudomonas putida strain R51 can efficiently degrade the 13-lactam antibiotic meropenem (MEM), and its degradation rate increases significantly under cadmium stress. The genome of strain R51 contains various heavy metal and antibiotic resistance genes. Molecular docking analysis showed that metallo-13-lactamase binds to MEM. These findings have importance for studying the microbial degradation of MEM in the presence of heavy metal pollutants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Yong Guk Ju, Hak Joon Lee, Hong Soon Yim, Min-Goo Lee, Jang Wook Sohn, Young Kyung Yoon
Summary: This study investigated the in vitro activity of different antimicrobial combinations against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. The colistin-ceftolozane/tazobactam combination showed synergistic and bactericidal effects against CRAB isolates. These findings suggest that the colistin-ceftolozane/tazobactam combination could be a promising treatment option for CRAB infections.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Shadi Zeraatkar, Maedeh Tahan, Hamid Sadeghian, Razieh Nazari, Mostafa Behmadi, Mahdi Hosseini Bafghi
Summary: Drug resistance in bacteria is a daily challenge in clinical treatment, and nanoparticles show potential for combating bacterial infections.
JOURNAL OF BASIC MICROBIOLOGY
(2023)
Article
Infectious Diseases
Jae-Min Park, Kyung-Sook Yang, You-Seung Chung, Ki-Byung Lee, Jeong-Yeon Kim, Sun-Bean Kim, Jang-Wook Sohn, Young-Kyung Yoon
Summary: This study compared the clinical outcomes and safety of meropenem-colistin versus meropenem-tigecycline in treating adult patients with carbapenem-resistant Acinetobacter baumannii (CRAB) pneumonia. The results suggest that meropenem-tigecycline combination therapy may be a valuable treatment option, while episodes of nephrotoxicity were significantly more common in the meropenem-colistin group.
Article
Infectious Diseases
Bence Balazs, Zoltan Toth, Fruzsina Nagy, Renato Kovacs, Hajnalka Toth, Jozsef Balint Nagy, Akos Toth, Krisztina Szarka, Laszlo Majoros, Gabor Kardos
Summary: The dominant carbapenem resistant Acinetobacter baumannii carrying bla(OXA-23-like) carbapenemase was replaced by strains carrying bla(OXA-40-like) in a Hungarian tertiary-care center with high meropenem but relatively low imipenem usage. Alterations in antibiotic consumption, particularly the uniform usage of meropenem, may have contributed to this strain replacement. Time-kill assays showed significant differences in susceptibility to meropenem between different sequence types, but not in imipenem resistance.
Article
Microbiology
Apinya Boonpeng, Sutep Jaruratanasirikul, Monchana Jullangkoon, Maseetoh Samaeng, Thitima Wattanavijitkul, Rungsun Bhurayanontachai, Sutthiporn Pattharachayakul
Summary: This study characterized the population pharmacokinetic parameters of meropenem in critically ill patients, finding that dosages achieving free plasma concentrations above the MIC target may improve therapeutic outcomes. Factors such as creatinine clearance, serum albumin levels, and shock status were significant covariates influencing drug metabolism and distribution.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Medicine, General & Internal
Chienhsiu Huang, Ihung Chen, Yalun Yang
Summary: This study aimed to explore the efficacy and safety of doripenem therapy for nosocomial pneumonia compared to other antimicrobial agents. The meta-analysis results showed that doripenem therapy had similar clinical and microbiological cure rates, all-cause mortality, and adverse events compared to the comparator agents. However, further randomized controlled trials are needed to confirm the role of doripenem in nosocomial pneumonia therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Haixian Liu, Wen Chen, Yu Tan, Guozhe Meng, Hongfang Liu, YFrank Cheng, Hongwei Liu
Summary: This study investigates the effects of biomineralization film caused by marine P. stutzeri on the corrosion of X80 pipeline steel. The results show that the film is mainly composed of nano Fe3O4 and FeOOH, with particle sizes below 10 nm. The research provides insights into preparing nanomaterials through MIC caused by P. stutzeri.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jae Ha Lee, Dong-Hwan Lee, Jin Soo Kim, Won-Beom Jung, Woon Heo, Yong Kyun Kim, Se Hun Kim, Tae-Hoon No, Kyeong Min Jo, Junghae Ko, Ho Young Lee, Kyung Ran Jun, Hye Sook Choi, Ji Hoon Jang, Hang-Jea Jang
Summary: This study found that the pharmacokinetics of meropenem in critically ill patients receiving ECMO were similar to those in patients without ECMO. Monte Carlo simulations have determined appropriate dosage regimens for meropenem, but dose adjustments may be needed for more aggressive targets.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zeming Wang, Jing Bi, Dianping You, Yu Tang, Gang Liu, Jinqian Yu, Zhipeng Jin, Tingting Jiang, Xue Tian, Hui Qi, Lei Dong, Lili Dong, Qunqun Zhang, Wei Zhao, Adong Shen
Summary: This study evaluated the relationship between the time in which the plasma free concentration of meropenem exceeds the minimum inhibitory concentration of pathogens during therapy and the clinical outcome of treatment. It found that sufficient target attainment of meropenem can improve the antibacterial efficacy of treatment without causing any adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Remy A. Bonnin, Sandrine Bernabeu, Cecile Emeraud, Thierry Naas, Delphine Girlich, Agnes B. Jousset, Laurent Dortet
Summary: This study demonstrated the high in vitro efficacy of ceftazidime/avibactam, imipenem/relebactam, and to a lesser extent meropenem/vaborbactam against carbapenem-resistant non-carbapenemase-producing Enterobacterales. Testing all beta-lactam/beta-lactamase inhibitor combinations is crucial for carbapenem-resistant Enterobacterales (CRE) as resistance to one combination does not predict resistance to another, depending on the resistance mechanisms involved.
Article
Infectious Diseases
Vineet Dubey, Kuldip Devnath, Vivek K. Gupta, Gazal Kalyan, Mangal Singh, Ashish Kothari, Balram Ji Omar, Ranjana Pathania
Summary: This study evaluated the efficacy of the FDA-approved drug disulfiram in combination with meropenem against MBL-expressing carbapenem-resistant Acinetobacter baumannii. The results demonstrated a synergistic interaction between disulfiram and meropenem, particularly against NDM and IMP-producing A. baumannii. The combination therapy showed improved bacterial clearance in mice models of infection and pneumonia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Jihye Yang, Sohyeon Yun, Woojun Park
Summary: The presence or absence of BlsA protein in Acinetobacter species genomes has raised curiosity about its role in regulating bacterial lifestyle under light. Genetic and transcriptomic analyses revealed the loss of BlsA in several multidrug-resistant strains and the light-mediated induction of blsA. Furthermore, the study identified a potential interaction partner of BlsA, BipA, and confirmed their direct interactions under specific conditions.
Article
Food Science & Technology
Lucy J. Robertson, Rakesh Sehgal, Kapil Goyal
FOOD RESEARCH INTERNATIONAL
(2015)
Letter
Infectious Diseases
Kapil Goyal, Alka Sehgal, Rakesh Sehgal
LANCET INFECTIOUS DISEASES
(2015)
Letter
Infectious Diseases
Sapna Pahil, Kapil Goyal, Mini P. Singh
LANCET INFECTIOUS DISEASES
(2015)
Article
Chemistry, Multidisciplinary
Yasmin R. H. Saleh, Haythem A. Saadeh, Hargobinder Kaur, Kapil Goyal, Rakesh Sehgal, Mohammad S. Mubarak
MONATSHEFTE FUR CHEMIE
(2015)
Article
Infectious Diseases
Mini P. Singh, Manasi Majumdar, Kapil Goyal, P. V. M. Lakshmi, Deepak Bhatia, R. K. Ratho
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2016)
Article
Chemistry, Medicinal
Gurjaspreet Singh, Aanchal Arora, Satinderpal Singh Mangat, Sunita Rani, Hargobinder Kaur, Kapil Goya, Rakesh Sehgal, Indresh Kumar Maurya, Rupinder Tewari, Duane Choquesillo-Lazarte, Subash Sahoo, Navneet Kaur
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Letter
Immunology
M. P. Singh, K. Goyal
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2016)
Letter
Immunology
Kapil Goyal, Hargobinder Kaur, Alka Sehgal, Rakesh Sehgal
JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Virology
Mini P. Singh, Manasi Majumdar, Bimal Budhathoki, Kapil Goyal, Yogesh Chawla, Radha K. Ratho
JOURNAL OF MEDICAL VIROLOGY
(2014)
Letter
Infectious Diseases
Kapil Goyal, Hargobinder Kaur, Rakesh Sehgal
LANCET INFECTIOUS DISEASES
(2014)
Article
Gastroenterology & Hepatology
Manasi Majumdar, Mini P. Singh, Kapil Goyal, Yogesh Chawla, Radha K. Ratho
LIVER INTERNATIONAL
(2015)
Article
Chemistry, Medicinal
Dua' Y. Alawadi, Haythem A. Saadeh, Hargobinder Kaur, Kapil Goyal, Rakesh Sehgal, Taibi Ben Hadda, Naser A. ElSawy, Mohammad S. Mubarak
MEDICINAL CHEMISTRY RESEARCH
(2015)
Article
Chemistry, Medicinal
Nabil E. Kassan, Haythem A. Saadeh, Wamid H. Talib, Adel M. Mahasneh, Hargobinder Kaur, Kapil Goyal, Rakesh Sehgal, Mohammad S. Mubarak
MEDICINAL CHEMISTRY RESEARCH
(2014)
Article
Chemistry, Medicinal
Haythem A. Saadeh, Khaled M. Al-Qaoud, Luay F. Abu-Qatouseh, Penelope A. Shihab, Hargobinder Kaur, Kapil Goyal, Rakesh Sehgal, Mohammad S. Mubarak
MEDICINAL CHEMISTRY RESEARCH
(2015)
Article
Chemistry, Multidisciplinary
Malath A. Al-Qtaitat, Haythem A. Saadeh, Amal G. Al-Bakri, Hargobinder Kaur, Kapil Goyal, Rakesh Sehgal, Mohammad S. Mubarak
MONATSHEFTE FUR CHEMIE
(2015)
Review
Immunology
G. Vithiya, P. Shunmuga Sundaram
Summary: This case describes a patient who developed infection after percutaneous transluminal coronary angioplasty and subsequently died due to improper treatment, primarily caused by endocarditis caused by M. abscessus.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
Article
Immunology
Pheba Stanley, Nonika Rajkumari, Monika Sivaradjy
Summary: The study aimed to detect the mutation patterns in drug targets in Plasmodium vivax that develop resistance to common antimalarial agents in India. By analyzing 27 Plasmodium vivax isolates, the study found an increase in the proportion of double mutants in pvmdr1 and pvdhfr over time. Cases with double mutant pvmdr1 gene had a prolonged hospital stay compared to those without, indicating reduced clinical response to chloroquine.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
Letter
Immunology
Amnuay Kleebayoon, Viroj Wiwanitkit
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
