Article
Pharmacology & Pharmacy
Islam A. Arida, Isra H. Ali, Maha Nasr, Ibrahim M. El-Sherbiny
Summary: This review article discusses the importance of nanofiber scaffolds in wound healing for skin tissues, highlighting the various parameters affecting the electrospinning process and the incorporation of bioactive molecules for improved bioactivity and efficiency.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Cheryl L. San Emeterio, Lauren A. Hymel, Thomas C. Turner, Molly E. Ogle, Emily G. Pendleton, William Y. York, Claire E. Olingy, Alan Y. Liu, Hong Seo Lim, Todd A. Sulchek, Gordon L. Warren, Luke J. Mortensen, Peng Qiu, Young C. Jang, Nick J. Willett, Edward A. Botchwey
Summary: Volumetric muscle loss (VML) is a significant clinical challenge after extremity trauma, and an immunomodulatory biomaterial therapy shows promise in addressing this issue. Modulating S1P receptor signaling can enhance muscle stem cell abundance and myofiber diameter, aiding in regeneration following VML injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Polymer Science
Xuan Yan, Haiyan Yao, Jun Luo, Zhihua Li, Junchao Wei
Summary: This review introduces bone-tissue engineering and the use of electrospun nanofibers as scaffolds. The unique characteristics of electrospun nanofibers, such as their similarity with the extracellular matrix, larger surface areas, porosity, and processability, make them ideal candidates for bone-tissue engineering. The review highlights the functionalization of electrospun nanofibers to enhance bone regeneration and addresses the existing deficiencies in promoting osteogenesis.
Article
Biotechnology & Applied Microbiology
Yuqing Niu, Massimiliano Galluzzi, Fuming Deng, Zhang Zhao, Ming Fu, Liang Su, Weitang Sun, Wei Jia, Huimin Xia
Summary: The study found that the hyaluronic acid-coating silk fibroin nanofiber scaffold can effectively regulate the epithelialization process of urethral regeneration, promoting luminal epithelialization, smooth muscle bundle structural remodeling, and capillary formation.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mairobi Persinal-Medina, Sara Llames, Manuel Chacon, Natalia Vazquez, Marta Pevida, Ignacio Alcalde, Sergio Alonso-Alonso, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: This study developed a polymerizable skin hydrogel consisting of keratinocytes and fibroblast within a fibrin scaffold. The results showed that this hydrogel can effectively regenerate skin wounds, shortening the time needed for transplantation compared to other skin models. It is suggested that this polymerizable skin hydrogel is an inexpensive, easy and rapid treatment for improving the treatment of skin wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Review
Biochemistry & Molecular Biology
Moon Sung Kang, Jinju Jang, Hyo Jung Jo, Won-Hyeon Kim, Bongju Kim, Heoung-Jae Chun, Dohyung Lim, Dong-Wook Han
Summary: This review focuses on the advances and innovations of 3D bioprinted skin for skin regeneration. By improving materials, structures, and functions, the clinical potential of 3D bioprinted skin has been enhanced. With state-of-the-art printing technology and novel biomaterials, highly developed skin comprising stratified epidermis, dermis, and hypodermis with blood vessels, nerves, muscles, and skin appendages can be fabricated. We hope that this review will guide future research and clinical applications.
Article
Chemistry, Physical
Yujie Chen, Wei Xu, Muhammad Shafiq, Jincheng Tang, Junxiang Hao, Xianrui Xie, Zhengchao Yuan, Xianghao Xiao, Yu Liu, Xiumei Mo
Summary: This study successfully fabricated two-dimensional and three-dimensional electrospun poly(L-lactide-co-epsilon-caprolactone)/silk fibroin scaffolds with nanofibrous structure and biological function, further mimicking the microarchitecture of native cartilage through crosslinking. The three-dimensional scaffolds showed better mechanical properties, while the biocompatibility, chondrocyte proliferation, and phenotypic maintenance were superior in the three-dimensional scaffolds as well.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lucy Vojtova, Veronika Pavlinakova, Johana Muchova, Katarina Kacvinska, Jana Brtnikova, Martin Knoz, Bretislav Lipovy, Martin Faldyna, Eduard Gopfert, Jakub Holoubek, Zdenek Pavlovsky, Monika Vicenova, Veronika Hefka Blahnova, Vanessa Hearnden, Eva Filova
Summary: The study demonstrates the application of a novel FGF2 variant on collagen/chitosan scaffolds, indicating its positive effects on wound healing and vascularization.
Article
Chemistry, Multidisciplinary
Ju An Park, Yejin Youm, Hwa-Rim Lee, Yongwoo Lee, Sarah L. Barron, Taejeong Kwak, Gyu Tae Park, Young-Cheol Song, Roisin M. Owens, Jae Ho Kim, Sungjune Jung
Summary: A cell sheet transfer method from a culture surface to a target tissue is introduced in this study. UV-treated parylene, a commercially available flexible material, is used as the culture surface to provide adequate cell adhesiveness for both cell attachment during culture and efficient transfer. Various cell types are successfully transferred using this versatile cell-transfer process. The mechanism of interfacial cell migration between surfaces with different adhesion preferences is observed, and the re-establishment and reversal of cell polarity after transfer are identified. The unique capabilities of 3D multilayer stacking, freeform design, and curved surface application are demonstrated. The therapeutic potential of the cell-sheet delivery system is demonstrated through experiments on cutaneous wound healing and skin-tissue regeneration in mice models.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Ruth Jinfen Chai, Wan Ling Wong, Cyrus Weijie Beh
Summary: Patients with severe burns require rapid intervention to prevent hypothermia, infection, and fluid loss. Current treatments involve surgical excision of burned skin and reconstruction with skin autografts. However, alternative treatments such as cultured epithelial autografts and spray-on skin have their own challenges. Bioprinting technology has been explored to fabricate skin grafts using collagen-based bioink and appropriate cell types.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Review
Polymer Science
Mohammad Reza Aghazadeh, Sheyda Delfanian, Pouria Aghakhani, Shahin Homaeigohar, Atefeh Alipour, Hosein Shahsavarani
Summary: Natural cellulose, obtained from bacterial and plant-based sources, shows potential as a biomaterial for tissue engineering by mimicking the extracellular matrix. Current research progress suggests that while meeting clinical application criteria is still a challenge, it is not an unachievable goal.
Article
Nanoscience & Nanotechnology
Sangmun Choi, Iruthayapandi Selestin Raja, Aravindha Raja Selvaraj, Moon Sung Kang, Tae-Eon Park, Ki Su Kim, Suong-Hyu Hyon, Dong-Wook Han, Jong-Chul Park
Summary: Carbon nanotubes are commonly used one-dimensional carbonaceous nanomaterials in tissue engineering, while other forms of one-dimensional nanomaterials, such as carbon nanowires and carbon nanofibers, have not been extensively explored for biomedical applications. In this study, activated carbon nanofiber nanoparticles (ACNF NPs) were synthesized from polyacrylonitrile electrospun nanofibers. Two different types of ACNF NPs-containing electrospun polycaprolactone (PCL) nanofiber mats were prepared and evaluated for their potential as skin tissue engineering scaffolds. The results showed that ACNF NPs exhibited a graphitization degree with an I-D/I-G ratio of 1.05, and had a diameter of 280 +/- 100 nm and a length of 565-3322 nm. NPs with a concentration above 30 μg/mL exhibited toxicity to NIH3T3 fibroblasts. The ACNF-PCL nanofiber mats demonstrated better cell proliferation compared to PCL and ACNF@PCL mats. Therefore, it can be concluded that ACNF-PCL mats with a lower concentration of ACNF NPs have greater potential to support cellular growth and impact skin tissue regeneration.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Biophysics
Yujie Chen, Zihao Jia, Muhammad Shafiq, Xianrui Xie, Xianghao Xiao, Rita Castro, Joao Rodrigues, Jinglei Wu, Guangdong Zhou, Xiumei Mo
Summary: In situ gas foaming was used to create 3D PLCL/SF scaffolds with nanotopographic cues and a multilayered structure, enhancing hydrophilicity and biocompatibility. These scaffolds had larger pore size and high porosity compared to 2D counterparts, promoting deposition of ECM components and new vessel regeneration. The 3D scaffolds also showed increased numbers of CD163(+)/CCR7(+) cells after implantation in a subcutaneous model, highlighting their potential in regenerative medicine and tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Gerardo Asensio, Marcela Martin-del-Campo, Rosa Ana Ramirez, Luis Rojo, Blanca Vazquez-Lasa
Summary: Sr/Zn phytate compounds have antimicrobial effects and can form bioactive coatings. Phytic acid has antioxidant and osteogenic properties that are important for bone remodelling. The study explored the antioxidant and osteogenic properties of SrPhy and ZnPhy and found that they can be used in bone regenerative therapies.