Specific therapy to regulate inflammation in rheumatoid arthritis: molecular aspects

Divergent Effects of Infliximab and Anakinra Therapies on Macrophage Phenotype from Patients with Refractory Rheumatoid Arthritis

(2017) T.N.Q. Pham et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Infliximab Reduces the Frequency of Interleukin 17-Producing Cells and the Amounts of Interleukin 17 in Patients With Rheumatoid Arthritis

(2016) Hui Shen et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Development of a Novel Noncompetitive Antagonist of IL-1 Receptor

(2014) C. Quiniou et al.   JOURNAL OF IMMUNOLOGY

The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells

(2013) Satoshi Kubo et al.   ANNALS OF THE RHEUMATIC DISEASES

Rituximab-Induced T Cell Depletion in Patients With Rheumatoid Arthritis: Association With Clinical Response

(2013) J. Mélet et al.   ARTHRITIS AND RHEUMATISM

CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients

(2013) Jennifer Pieper et al.   BMC IMMUNOLOGY

Drug levels, anti-drug antibodies, and clinical efficacy of the anti-TNFα biologics in rheumatic diseases

(2013) C. C. Mok et al.   CLINICAL RHEUMATOLOGY

Interleukin-6 Receptor Blockade Selectively Reduces IL-21 Production by CD4 T Cells and IgG4 Autoantibodies in Rheumatoid Arthritis

(2013) Gustavo Carbone et al.   International Journal of Biological Sciences

Efficacy and Safety of Belimumab in Patients with Rheumatoid Arthritis: A Phase II, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study

(2013) W. Stohl et al.   JOURNAL OF RHEUMATOLOGY

Anti-TNF Therapy Reduces Serum Levels of Chemerin in Rheumatoid Arthritis: A New Mechanism by Which Anti-TNF Might Reduce Inflammation

(2013) Marieke M. J. Herenius et al.   PLoS One

Anti-TNF treatment blocks the induction of T cell-dependent humoral responses

(2012) Gabriela Franco Salinas et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

(2012) Jenny L. McGovern et al.   ARTHRITIS AND RHEUMATISM

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK-3 or MKK-6

(2012) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

Abatacept (CTLA-4IG) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis

(2012) M. Bonelli et al.   ARTHRITIS AND RHEUMATISM

Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients

(2012) B. Pesce et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infliximab reduces CD147, MMP-3, and MMP-9 expression in peripheral blood monocytes in patients with active rheumatoid arthritis

(2012) Jianlin Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of JAKs in Macrophages Increases Lipopolysaccharide-Induced Cytokine Production by Blocking IL-10-Mediated Feedback

(2012) M. J. Pattison et al.   JOURNAL OF IMMUNOLOGY

Characterization of 99mTc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways

(2012) Zhonglin Liu et al.   NUCLEAR MEDICINE AND BIOLOGY

Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis

(2012) Luis Chara et al.   ARTHRITIS RESEARCH & THERAPY

Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function

(2011) G. Lal et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience

(2011) Ngayu Thairu et al.   ANGIOGENESIS

Monocyte migration to the synovium in rheumatoid arthritis patients treated with adalimumab

(2011) M. M. J. Herenius et al.   ANNALS OF THE RHEUMATIC DISEASES

The anti-CD20 antibody rituximab reduces the Th17 cell response

(2011) Frank L. van de Veerdonk et al.   ARTHRITIS AND RHEUMATISM

MEK inhibitors: a patent review 2008 – 2010

(2011) John I Trujillo   EXPERT OPINION ON THERAPEUTIC PATENTS

Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets

(2011) Octavio Aravena et al.   IMMUNOBIOLOGY

Decrease of CD68 and MMP-3 expression in synovium by treatment of adalimumab for rheumatoid arthritis

(2011) Katsuaki KANBE et al.   International Journal of Rheumatic Diseases

CTLA-4-Ig Therapy Diminishes the Frequency but Enhances the Function of Treg Cells in Patients with Rheumatoid Arthritis

(2011) Crisol Álvarez-Quiroga et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor

(2011) James J Kobie et al.   ARTHRITIS RESEARCH & THERAPY

Insertion of multiple α-amino γ-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns

(2010) Luisa Ronga et al.   BIOPOLYMERS

IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production

(2010) K. Maeda et al.   BLOOD

The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells

(2010) M. Fujimoto et al.   JOURNAL OF IMMUNOLOGY

Targeting the Glycoprotein 130 Receptor Subunit to Control Pain and Inflammation

(2010) Jalal A. Jazayeri et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules

(2010) Chengbin Wu et al.   mAbs

Effects of Inhibition of Interleukin-6 Signalling on Insulin Sensitivity and Lipoprotein (A) Levels in Human Subjects with Rheumatoid Diseases

(2010) Olaf Schultz et al.   PLoS One

Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression

(2010) N. E. Aerts et al.   RHEUMATOLOGY

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Alterations in Cytokine Profile and Dendritic Cells Subsets in Peripheral Blood of Rheumatoid Arthritis Patients before and after Biologic Therapy

(2009) Luciana Marti et al.   Annals of the New York Academy of Sciences

Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis

(2009) H. M. Baldwin et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies

(2009) Nemanja Damjanov et al.   ARTHRITIS AND RHEUMATISM

Normalization of A2Aand A3adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor α but not methotrexate

(2009) Katia Varani et al.   ARTHRITIS AND RHEUMATISM

Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody

(2009) Masahiko Mihara et al.   BIOFACTORS

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Blocking T cell co-stimulation using a CD80 blocking small molecule reduces delayed type hypersensitivity responses in rhesus monkeys

(2009) K. G. Haanstra et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Depletion of B lymphocytes in rheumatoid arthritis patients modifies IL-8-anti-IL-8 autoantibody network

(2009) Zohar Keren et al.   CLINICAL IMMUNOLOGY

Influenza vaccine administration in rheumatoid arthritis patients under treatment with TNFα blockers: Safety and immunogenicity

(2009) S. Salemi et al.   CLINICAL IMMUNOLOGY

Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains

(2009) Neal K. Williams et al.   JOURNAL OF MOLECULAR BIOLOGY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients

(2009) Cai Yue et al.   RHEUMATOLOGY INTERNATIONAL

CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production

(2009) Maurizio Cutolo et al.   ARTHRITIS RESEARCH & THERAPY

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

(2008) Ignatios Ikonomidis et al.   CIRCULATION

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

(2008) Jian-kang Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs

(2008) L. J. Holt et al.   PROTEIN ENGINEERING DESIGN & SELECTION