Current landscape for T-cell targeting in autoimmunity and transplantation

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

Homeostatic Repopulation by CD28−CD8+ T Cells in Alemtuzumab-Depleted Kidney Transplant Recipients Treated With Reduced Immunosuppression

(2010) P. Trzonkowski et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

(2010) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Five-Year Safety and Efficacy of Belatacept in Renal Transplantation

(2010) F. Vincenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Have we overestimated the benefit of human(ized) antibodies?

(2010) Daniel R. Getts et al.   mAbs

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Transplantation tolerance through mixed chimerism

(2010) Nina Pilat et al.   Nature Reviews Nephrology

Population Pharmacokinetic Analysis of Mycophenolic Acid Coadministered With Either Tasocitinib (CP-690,550) or Tacrolimus in Adult Renal Allograft Recipients

(2010) Manisha Lamba et al.   THERAPEUTIC DRUG MONITORING

Binding of Thymoglobulin to Natural Killer Cells Leads to Cell Activation and Interferon-γ Production

(2010) Jean-Hugues Dalle et al.   TRANSPLANTATION

Mixed Chimerism, Lymphocyte Recovery, and Evidence for Early Donor-Specific Unresponsiveness in Patients Receiving Combined Kidney and Bone Marrow Transplantation to Induce Tolerance

(2010) Samuel A. LoCascio et al.   TRANSPLANTATION

Belatacept-Based Regimens Versus a Cyclosporine A-Based Regimen in Kidney Transplant Recipients: 2-Year Results From the BENEFIT and BENEFIT-EXT Studies

(2010) Christian P. Larsen et al.   TRANSPLANTATION

Pharmacokinetics of Sotrastaurin Combined With Tacrolimus or Mycophenolic Acid in De Novo Kidney Transplant Recipients

(2010) John M. Kovarik et al.   TRANSPLANTATION

Regulatory T Cells Are Reduced During Anti-CD25 Antibody Treatment of Multiple Sclerosis

(2009) Unsong Oh et al.   ARCHIVES OF NEUROLOGY

Effect of Anti-CD25 Antibody Daclizumab in the Inhibition of Inflammation and Stabilization of Disease Progression in Multiple Sclerosis

(2009) Bibiana Bielekova et al.   ARCHIVES OF NEUROLOGY

Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment

(2009) Stanley Cohen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Protein kinase C intervention—the state of play

(2009) Jon Roffey et al.   CURRENT OPINION IN CELL BIOLOGY

Infections after the use of alemtuzumab in solid organ transplant recipients: a comparative study

(2009) Nasia Safdar et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

A Semi-Mechanistic Model of CP-690,550-Induced Reduction in Neutrophil Counts in Patients With Rheumatoid Arthritis

(2009) Pankaj Gupta et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Daclizumab versus Antithymocyte Globulin in High-Immunological-Risk Renal Transplant Recipients

(2009) C. Noel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting of Natural Killer Cells by Rabbit Antithymocyte Globulin and Campath-1H: Similar Effects Independent of Specificity

(2009) Diana Stauch et al.   PLoS One

Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720

(2009) Gisbert Weckbecker et al.   TRANSPLANT INTERNATIONAL

The Effect of the JAK Inhibitor CP-690,550 on Peripheral Immune Parameters in Stable Kidney Allograft Patients

(2009) Evelien A. F. J. van Gurp et al.   TRANSPLANTATION

Polyclonal Rabbit Antithymocyte Globulin Exhibits Consistent Immunosuppressive Capabilities Beyond Cell Depletion

(2009) Gina LaCorcia et al.   TRANSPLANTATION

What's Next in the Pipeline

(2008) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Phase 1 Dose-Escalation Study of CP-690 550 in Stable Renal Allograft Recipients: Preliminary Findings of Safety, Tolerability, Effects on Lymphocyte Subsets and Pharmacokinetics

(2008) E. van Gurp et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

(2008) Hans Skvara et al.   JOURNAL OF CLINICAL INVESTIGATION

CMV infections after two doses of daclizumab versus thymoglobulin in renal transplant patients receiving mycophenolate mofetil, steroids and delayed cyclosporine A

(2008) R. Abou-Ayache et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Long-Term Results of Rabbit Antithymocyte Globulin and Basiliximab Induction

(2008) Daniel C. Brennan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression

(2008) Tatsuo Kawai et al.   NEW ENGLAND JOURNAL OF MEDICINE

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical experience with mixed chimerism to induce transplantation tolerance

(2008) Thomas Fehr et al.   TRANSPLANT INTERNATIONAL

A Prospective, Randomized, Double-Blinded Comparison of Thymoglobulin Versus Atgam for Induction Immunosuppressive Therapy: 10-Year Results

(2008) Karen L. Hardinger et al.   TRANSPLANTATION