Article
Biochemistry & Molecular Biology
Shi-Le Wang, Man-Man Zhang, Han Zhou, Guo-Qiang Su, Yi Ding, Guang-Hui Xu, Xu Wang, Cheng-Fu Li, Wei-Feng Huang, Li-Tao Yi
Summary: This study suggests that inhibition of NLRP3 inflammasome regulates gut microbiota and attenuates IBD-like symptoms, providing a basis for the clinical application of NLRP3 as a target for the treatment of IBD.
BIOMEDICAL JOURNAL
(2023)
Article
Pathology
Li-Yin Hung, Christopher F. Pastore, Bonnie Douglas, De'Broski R. Herbert
Summary: The study demonstrates that myeloid-derived IL-33 plays a key role in restraining colitic disease, while intestinal epithelial cell-derived IL-33 is dispensable for disease severity or tissue recovery.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Dadi Xie, Fengfeng Li, Deshui Pang, Shiyuan Zhao, Meihua Zhang, Zhongfa Ren, Chunmei Geng, Changshui Wang, Ning Wei, Pei Jiang
Summary: This study aimed to evaluate the utility metabolomic analysis of target tissues in exploring new biomarkers for early diagnosis and treatment of IBD. The results showed significant changes in amino acid, organic acid, glucide, and purine profiles, impacting pathways ranging from amino acid metabolism to purine metabolism. Using GC-MS-based profiling of metabolite changes may provide a more comprehensive view for understanding IBD pathogenesis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Microbiology
Bihui Liu, Lei Yang, Ya Wu, Xin Zhao
Summary: This study investigated the effects of Limosilactobacillus fermentum HFY06 (LF-HFY06) on murine colitis. The results showed that LF-HFY06 increased colon length and ameliorated pathological damage, enhanced antioxidant enzyme activities, reduced inflammatory cytokine levels, and inhibited inflammation through the NF-κB signaling pathway. LF-HFY06 has the potential to prevent and treat colitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rahamat Unissa Syed, Sivakumar S. Moni, Muhammad Nawaz, Mohammed Khaled Bin Break, Nasrin E. Khalifa, Siddig Ibrahim Abdelwahab, Reham Meshal Alharbi, Raghad Huraid Alfaisal, Bayan Naif Al Basher, Entsar Mohammed Alhaidan
Summary: Amikacin sulfate-loaded dextran sulfate sodium nanoparticles (LADNP) were prepared and analyzed. LADNP had a zeta potential of -20.9 +/- 8.35 mV, PDI of 0.256, and % PDI of 67.7. The size of LADNP was 317.9 d. nm, with individual particles measuring 259.3 +/- 73.52 nm. The release kinetics of amikacin from LADNP demonstrated zero order kinetics, with 37% of the drug released in 7 hours.
Article
Immunology
Jie Wang, Ke Shi, Shuaifei Li, Lu Chen, Wentao Liu, Xudong Wu, Yan Shen, Yang Sun, Jingcai Cheng, Xuefeng Wu, Qiang Xu
Summary: Meisoindigo effectively alleviates experimental colitis in mice by regulating the levels of various molecules and inflammatory cytokines, suppressing NF-κB pathway activation. In addition, meisoindigo targets TAK1 to inhibit inflammatory responses, providing a novel direction for clinical anti-inflammatory therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Min Seo Kim, Yong Dae Kim, Seunghee Kang, Oran Kwon, Jae-Ho Shin, Ji Yeon Kim
Summary: In this study, the effect of cinnamon subcritical water extract (CSE) on gut health in a mouse colitis model induced by dextran sodium sulfate was evaluated. Results showed that CSE improved clinical symptoms, reduced inflammatory markers, increased expression of tight junction proteins, and altered the microbiome to reduce inflammation. These findings suggest that CSE could prevent colitis-induced intestinal disruption.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Ruizheng Sun, Hao Chen, Siqi Yao, Zheng Yu, Chen Lai, Jing Huang
Summary: This study focused on the role of gut microbiota in the early stage of the AOM-DSS model. AOM and the first round of DSS treatment led to acute colitis, which is crucial for the success of the AOM-DSS model. The researchers observed changes in the ecological dynamics of gut microbiota in AOM-DSS treated mice, with certain bacterial genera showing uncontrolled proliferation associated with rapid deterioration and death. Conversely, other genera were significantly enriched in surviving mice. A decrease in certain bacterial genera in the colitis model could be lethal, and dysbiosis of the intestinal flora and fragility of the microbial network were observed in deceased mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren, Wei Zhang
Summary: This study found that high altitude hypoxia exacerbates the severity of ulcerative colitis in mice by activating the increase of inflammatory Th1 and Th17 lymphocytes.
Article
Agriculture, Dairy & Animal Science
Lixuan Liu, Wenjing Sui, Yajin Yang, Lily Liu, Qingqing Li, Aiwei Guo
Summary: This study evaluated the feasibility of using DSS to establish an enteritis broiler model. The results showed that DSS effectively induced enteric inflammation in broilers, resulting in poor growth performance and severe histopathological damage in the jejunum. These findings suggest that oral gavage of DSS is an effective method for inducing mild and non-necrotic enteric inflammation in broilers.
Article
Spectroscopy
Yiwen Zhao, Yanping Jiang, Qianwei Wang, Yana Sun, Kunlun Huang, Zhiyi Yao
Summary: A sensitive and selective method for detecting DSS in aqueous solution was established using the hydrosoluble perylene diimide (PDI) derivative. The sensing mechanism and performance of PDI-PdEC were systematically investigated, enabling sensitive and rapid detection of DSS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Food Science & Technology
Hye-Jung Moon, Suk-Heung Oh, Ki-Bum Park, Youn-Soo Cha
Summary: This study investigated the alleviating effects of kimchi and Leuconostoc mesenteroides DRC 1506 on ulcerative colitis (UC). Mice were orally given a dose of 1 x 10(9) CFU/day of freeze-dried kimchi suspension and DRC for 3 weeks, and UC was induced with dextran sulfate sodium (DSS). The results showed that the kimchi and DRC groups reduced colitis symptoms and improved the inflammatory response and mucosal barrier function in the colon.
Article
Biochemistry & Molecular Biology
Keita Adachi, Michiyasu Ishizawa, Shigeyuki Uno, Hitomi Kubota, Takuo Henmi, Tsugumichi Koshinaga, Makoto Makishima, Kenichi Sakurai
Summary: Oral administration of BaP has a protective effect against DSS-induced colitis, reducing inflammation and tissue damage without causing toxic metabolic activation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
