Article
Peripheral Vascular Disease
Piu Saha, Blair Mell, Rachel M. Golonka, Venugopal R. Bovilla, Ahmed A. Abokor, Xue Mei, Beng San Yeoh, Peter A. Doris, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Summary: This study reveals IgA deficiency in SHR as a host factor associated with gut microbiota dysbiosis and accelerates the development of hypertension. This finding is of great importance for further research on the role of IgA in hypertension.
Article
Gastroenterology & Hepatology
Janne Marie Moll, Pernille Neve Myers, Chenchen Zhang, Carsten Eriksen, Johannes Wolf, K. Sofia Appelberg, Greger Lindberg, Martin Iain Bahl, Hui Zhao, Qiang Pan-Hammarstroem, Kaiye Cai, Huijue Jia, Stephan Borte, H. Bjorn Nielsen, Karsten Kristiansen, Susanne Brix, Lennart Hammarstrom
Summary: This study compared the composition and functional capacity of gut microbiota between individuals with IgA deficiency and IgA-sufficient household members, highlighting the enrichment of pathogen-related bacterial species in the gut microbiota of IgAD individuals. The presence of IgA-specific autoantibodies further exacerbated the proinflammatory potential of the gut microbiota in individuals with IgAD, indicating the importance of screening for these autoantibodies to identify high-risk patients with gastrointestinal implications.
Review
Microbiology
Katherine Donald, Charisse Petersen, Stuart E. Turvey, B. Brett Finlay, Meghan B. Azad
Summary: Secretory immunoglobulin A (SIgA) in human milk plays a vital role in maternal-infant interactions and long-term immune system development. Recent studies have shown that SIgA not only clears pathogens, but also guides a healthy microbiota and influences immune system development. Future research should focus on understanding the role of SIgA in early life to support healthy immune development in infants.
CELL HOST & MICROBE
(2022)
Article
Immunology
Xuerun Liu, Luoyang Wang, Huiren Zhuang, Zhenghuan Yang, Guoqiang Jiang, Zheng Liu
Summary: Recent research has shown that anthocyanins have prebiotic attributes and can be used to treat microbiota-associated diseases. This study investigates the effects of bilberry anthocyanins on the gut microbiota composition, metabolism, and the intestinal mucosal immune system of mice. The findings suggest that oral administration of anthocyanins can help maintain intestinal homeostasis and may have applications in immunotherapy and related fields.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Oliver Pabst, Ana Izcue
Summary: SIgA regulates the composition and function of the gut microbiota through both generic and unique epitope-specific effects, as suggested by Rollenske and colleagues.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Endocrinology & Metabolism
Jielong Guo, Xue Han, Weidong Huang, Yilin You, Zhan Jicheng
Summary: Immunoglobulin A (IgA) is an important immunoglobulin isotype mainly found in intestinal mucosa, forming the first line of defense for intestinal epithelial cells along with mucus and antimicrobial peptides. Dysregulation of IgA function can lead to gut microbiota imbalance and metabolic syndrome.
Article
Cell Biology
Lisa Perruzza, Francesco Strati, Matteo Raneri, Hai Li, Giorgio Gargari, Tanja Rezzonico-Jost, Martina Palatella, Ivo Kwee, Diego Morone, Frauke Seehusen, Paolo Sonego, Claudio Donati, Pietro Franceschi, Andrew J. Macpherson, Simone Guglielmetti, Victor Greiff, Fabio Grassi
Summary: This study demonstrates that hydrolysis of extracellular ATP by apyrase results in amplification of the SIgA repertoire, influencing the distribution of bacteria and gene expression in the intestinal epithelium in mice. Apyrase-induced SIgA improves intestinal homeostasis, attenuating barrier impairment and susceptibility to infection.
Article
Gastroenterology & Hepatology
Kelsey E. Huus, Marcin Frankowski, Maja Pucic-Bakovic, Frano Vuckovic, Gordan Lauc, Benjamin H. Mullish, Julian R. Marchesi, Tanya M. Monaghan, Dina Kao, B. Brett Finlay
Summary: This study found that IgA-bacterial interactions are reestablished in human FMT recipients to resemble that of the healthy fecal donor. The data suggests that the IgA-bacterial interactions are influenced by the bacterial species and the fecal donor identity in the FMT recipients.
Article
Immunology
Zhenhua Wu, Xiaoyi Liu, Shimeng Huang, Tiantian Li, Xiangyu Zhang, Jiaman Pang, Junying Zhao, Lijun Chen, Bing Zhang, Junjun Wang, Dandan Han
Summary: Milk fat globule membrane (MFGM) can attenuate colitis and hepatic injury by enhancing the mucosal barrier and bacterial community while inhibiting oxidative stress.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hao Wei, Ji-Yang Wang
Summary: Transcytosis of polymeric IgA and IgM mediated by pIgR is essential for mucosal immunity. The J chain plays a crucial role in the formation and recognition of polymeric IgA and IgM by pIgR, while MZB1 may act as a regulator to facilitate IgA and IgM transcytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Megan S. Kennedy, Manjing Zhang, Orlando DeLeon, Jacie Bissell, Florian Trigodet, Karen Lolans, Sara Temelkova, Katherine T. Carroll, Aretha Fiebig, Adam Deutschbauer, Ashley M. Sidebottom, Joash Lake, Chris Henry, Phoebe A. Rice, Joy Bergelson, Eugene B. Chang
Summary: To understand how a bacterium succeeds or fails in adapting to a new host, it is important to assess its fitness dynamics over time during colonization. By introducing human-derived commensal organism Bacteroides thetaiotaomicron (Bt) into germ-free mice, researchers found that gene usage changes drastically during the early stages of colonization, from amino acid biosynthesis to polysaccharide utilization. These findings underscore the significance of considering temporal colonization dynamics in developing more effective microbiome-based therapies.
Article
Biochemistry & Molecular Biology
Katsuhiro Nakanishi, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Takeshi Matsuoka, Kotome Shiina, Shota Morikane, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai
Summary: The study demonstrates that plant-derived secretory component can enhance protease-resistance of SIgA, potentially contributing to its oral application. The reconstituted SIgA with plant-derived SC showed increased resistance to pepsin and trypsin, suggesting a promising alternative for efficient production of orally applicable SIgA.
PLANT MOLECULAR BIOLOGY
(2021)
Article
Microbiology
Rob van Dalen, Ahmed M. A. Elsherbini, Mareike Harms, Svenja Alber, Regine Stemmler, Andreas Peschel
Summary: This study provides a comprehensive insight into the targeting of the nasal microbiota by sIgA antibodies, helping to better understand the shaping and homeostasis of the nasal microbiome by the host and potentially guiding the development of effective mucosal vaccines against bacterial pathogens.
Article
Microbiology
Bing Xia, Ruqing Zhong, Weida Wu, Chengzeng Luo, Qingshi Meng, Qingtao Gao, Yong Zhao, Liang Chen, Sheng Zhang, Xin Zhao, Hongfu Zhang
Summary: Post-weaning diarrhea in piglets disrupts the colonic mucus layer and causes aberrant mucin O-glycans. This leads to gut microenvironment impairment, compromised epithelial barrier integrity, enhanced susceptibility to inflammation, and mild growth faltering. The activation of inflammasomes and autophagy restriction along with changes in microbiota are likely associated with diarrheal pathogenesis.
Article
Multidisciplinary Sciences
Lingjun Tong, Sitong Zhang, Qiqi Liu, Chenyuan Huang, Haining Hao, Michelle Siying Tan, Xiaodong Yu, Charles Kang Liang Lou, Rong Huang, Zhe Zhang, Tongjie Liu, Pimin Gong, Cheng Han Ng, Mark Muthiah, Giorgia Pastorin, Matthias Gerhard Wacker, Xiaoyuan Chen, Gert Storm, Cheun Neng Lee, Lanwei Zhang, Huaxi Yi, Jiong-Wei Wang
Summary: Milk-derived extracellular vesicles (mEVs) show similar protective effects on intestinal barrier integrity as well as the prevention of endotoxin translocation into the liver in gut inflammation and diet-induced metabolic diseases. Oral administration of mEVs restores gut barrier integrity and alleviates gut disorders and their associated liver inflammation, suggesting that mEVs have potential in the treatment of gut-liver axis-associated metabolic diseases via protection of intestinal barrier integrity.
