Article
Oncology
Muhammad Luqman Nordin, Abdin Shakirin Mohamad Norpi, Pei Yuen Ng, Khatijah Yusoff, Nadiah Abu, Kue Peng Lim, Fazren Azmi
Summary: The role of vaccination has been expanded in the management of HER2/neu-positive breast cancer, with effective vaccines needing to induce both humoral and cellular immune responses. A multi-epitope peptide vaccine including B-cell epitope was found to be superior in inhibiting tumor growth and prolonging survival in animal models. This highlights the importance of incorporating B-cell epitopes in cancer vaccine design.
Article
Immunology
Clarety Kaseke, Rhoda Tano-Menka, Fernando Senjobe, Gaurav D. Gaiha
Summary: The development of an effective HIV cure is crucial, with the role of CTLs in suppressing viral outgrowth without therapy being emphasized. Successful containment of the virus in vivo is dependent on targeting mutation-resistant regions within the HIV proteome, highlighting the potential for therapeutic vaccine development.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Adhika Balgobind, Aliscia Daniels, Mario Ariatti, Moganavelli Singh
Summary: This study assessed the efficacy of cationic lipid-based systems for the delivery of HER2/neu siRNA in breast cancer. The results showed that cationic liposomes efficiently bound, compacted, and protected the therapeutic siRNA against degradation. The non-PEGylated Chol-T-siRNA lipoplexes exhibited the highest HER2/neu silencing.
Article
Agriculture, Dairy & Animal Science
Farrukh Jamil, Laiba Aslam, Laraib, Hira Ali, Kainaat Shoukat, Muhammad Asif Rasheed, Sohail Raza, Muhammad Ibrahim
Summary: A new multi-epitope vaccine with higher efficiency against Newcastle disease virus (NDV) has been designed by shuffling cytotoxic T lymphocytes segments. This new vaccine construct shows improved immunogenicity, antigenicity, and stability, making it more effective against NDV strains in Pakistan.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Nastaran Barati, Fatemeh Mosaffa, Atefeh Razazan, Ali Badiee, Javad Behravan, Amin Reza Nikpoor, Seyed Mousa Motavallihaghi, Mahmoud Reza Jaafari
Summary: The study focuses on developing a nanoliposomal vaccine for HER2-overexpressing breast cancer to evaluate its immunotherapeutic effects. The findings demonstrate that the formulation is capable of eliciting CD8(+) and CD4(+) responses, inducing the synthesis of cytokines.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biology
Manaswini Jagadeb, Kali Prasad Pattanaik, Surya Narayan Rath, Avinash Sonawane
Summary: The study identified potential peptide-based vaccine targets against tuberculosis using an immune-informatics approach. By analyzing the Mtb proteome, two potential vaccine candidates were selected, showing the ability to induce protective immune responses. The peptides exhibited strong binding affinity and antigenic properties, suggesting their potential as vaccine candidates against TB.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Hiroko Nakajima, Jun Nakata, Kanako Imafuku, Hiromu Hayashibara, Kazuki Isokawa, Keiko Udaka, Fumihiro Fujiki, Soyoko Morimoto, Kana Hasegawa, Naoki Hosen, Yoshiko Hashii, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama
Summary: This study identified three novel mouse Th epitope peptides that strongly induced and maintained WT1-specific CTLs, efficiently rejected WT1-expressing tumor cells, and showed that these CTLs played a central role in tumor rejection. The majority of WT1-specific CTLs induced by the co-immunization with WT1 CTL and the WT1-specific Th peptides were effector memory CD8(+) T cells, demonstrating their essential function in WT1-specific tumor immunity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Materials Science, Biomaterials
Hyeonjeong Han, Jik-Han Jung, Hyoungjin Lee, Junsung Lee, Seong-Hoon Jang, Unbyeol Goh, Jooeun Yoon, Ji-Ho Park
Summary: This study presents a targeted fusogenic liposome (TFL) that selectively delivers lipophilic drugs to tumor cell membranes and distributes them throughout the tumor tissue via extracellular vesicles. Systemically administered TFL accumulates in the perivascular region of tumors and enables the autonomous transfer of lipophilic drugs among tumor cells. When loaded with a lipophilic pro-apoptotic drug, TFL effectively inhibits tumor growth in a mouse colorectal cancer model.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Immunology
Fang-Fang Zhang, Yaru Qiao, Yu Xie, Chenlu Liu, Hui Wu, Jia-Xin Wu, Xiang-Hui Yu, Wei Kong, Hai-Hong Zhang
Summary: This study demonstrates for the first time that the FAP.291 minigene vaccine can induce mouse CTLs and function as a tumor regression antigen. However, the analogue epitope FAP.291I9 did not enhance the anti-tumor immune response, possibly due to increased levels of immunosuppressive factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Aytul Gul, Mert Doskaya, Huseyin Can, Muhammet Karakavuk, Muge Anil-Inevi, Pelin Saglam-Metiner, Esra Atalay-Sahar, Aysu Degirmenci-Doskaya, Osman Zekioglu, Adnan Yuksel Guruz, Sultan Gulce-Iz, Levent Yeniay
Summary: Breast cancer ranked first in global cancer incidence in 2020, and HER2 overexpression accounts for a significant proportion of breast cancer patients. Resistance to current therapeutic strategies necessitates the development of novel treatments like DNA vaccines. This study generated a DNA vaccine that targets dendritic cells using multiepitope proteins to enhance immunogenicity. The results demonstrated that the DNA vaccine effectively elicited an immune response.
Article
Immunology
Loral E. Showalter, Brian J. Czerniecki, Krithika Kodumudi, Gary K. Koski
Summary: The study presents a serum-free culture method for generating activated mouse dendritic cells with excellent in vivo functionality, suitable for experimental vaccine studies. The DCs produced using this method showed similar characteristics to standard serum-replete cultures, including the capacity to sensitize against antigens and exhibit killer DC function against tumor cells.
Article
Virology
Michael C. McGee, Weishan Huang
Summary: Influenza infection is a major cause of respiratory diseases and deaths worldwide. To combat the threats from unpredictable emerging flu viruses and avian flu viruses, a universal vaccine is needed to protect against different subtypes and species. Research has identified a specific region on the influenza nucleoprotein that can elicit immune responses against different heterosubtypes, which may contribute to developing more effective flu vaccine strategies.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell Biology
Lei Feng, Yong-Yu Gao, Mingwei Sun, Zi-Bin Li, Qiang Zhang, Jie Yang, Cui Qiao, Hang Jin, Hong-Sheng Feng, Yu-Han Xian, Jianxun Qi, George F. F. Gao, William J. J. Liu, Feng-Shan Gao
Summary: This study identifies a series of T-cell epitopes with high binding capacity, which can be used for the development of universal vaccines.
Article
Oncology
Ju Bai, Jianli Wang, Yun Yang, Fangxia Wang, Aili He, Wanggang Zhang
Summary: Our research identified the HLA-A*0201-restricted cytotoxic T-lymphocyte (CTL) epitope MLAA-34(236-244) as having strong binding affinity and inducing significant interferon-gamma production. CTLs targeting this epitope showed potent cytotoxicity against leukemia cells and inhibited tumor growth. Additionally, immunization with the MLAA-34(236-244) peptide vaccine resulted in elevated levels of interferon-gamma and enhanced survival in mouse models of leukemia.
JOURNAL OF IMMUNOTHERAPY
(2021)
Review
Oncology
J. Tobias, E. Garner-Spitzer, M. Drinic, U. Wiedermann
Summary: Immunotherapy has revolutionized cancer treatment, with a focus on breast cancer. Traditional treatment methods have limitations, but tumor vaccines may offer a potential solution. This review discusses peptide-based Her-2 / neu vaccines and their evaluation in clinical settings.
Article
Multidisciplinary Sciences
Maedeh Alinezhad, Mohsen Bakhshandeh, Elham Rostami, Reza Alimohamadi, Nariman Mosaffa, Seyed Amir Jalali
Review
Cell Biology
Anh M. Tran, Ghanbar Mahmoodi Chalbatani, Lea Berland, Mireia Cruz de los Santos, Priyank Raj, Seyed Amir Jalali, Elahe Gharagouzloo, Cristina Ivan, Mihnea P. Dragomir, George A. Calin
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Reza Alinnohannnnadi, Razieh Alibeigi, Amin Reza Nikpoor, Ghanbar Mahmoodi Chalbatani, Thomas J. Webster, Mahmoud Reza Jaafari, Seyed Annir Jalali
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Multidisciplinary Sciences
Laleh Naghibi, Mona Yazdani, Amir Abbas Momtazi-Borojeni, Atefeh Razazan, Sheida Shariat, Mercedeh Mansourian, Atefeh Arab, Nastaran Barati, Mahdieh Arabsalmani, Azam Abbasi, Zahra Saberi, Ali Badiee, Seyed Amir Jalali, Mahmoud Reza Jaafari
Review
Pharmacology & Pharmacy
Hassan Dana, Ghanbar Mahmoodi Chalbatani, Seyed Amir Jalali, Hamid Reza Mirzaei, Stephan A. Grupp, Eloah Rabello Suarez, Catarina Raposo, Thomas J. Webster
Summary: New approaches in cancer immunotherapy, such as checkpoint inhibitors for solid tumors and CAR-T cell therapy for hematologic malignancies, have shown promising results. While CAR-T products have demonstrated powerful effects against B cell cancers, challenges exist in using them for solid tumors.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Parvin Zamani, Seyedeh Hoda Alavizadeh, Fatemeh Fakhraee, Ali Badiee, Seyed Amir Jalali, Omid Chavoshian, Ali Khamesipour, Masoumeh Tavassoti Kheiri, Fereidoun Mahboudi, Mahmoud Reza Jaafari
Summary: The study demonstrated that LPD-rLmaC1N/rgp63 significantly activates Th1 immune response, enhances IFN-gamma production and IgG2a levels. Immunization with LPD-rLmaC1N/rgp63 resulted in a significant reduction in the number of live parasites in the spleen and footpads of immunized mice compared to other vaccinated groups. Additionally, the footpad thickness was remarkably smaller in mice immunized with LPD-rLmaC1N/rgp63.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biology
Ghanbar Mahmoodi Chalbatani, Seyed Ali Momeni, Mohammad Hosein Mohammadi Hadloo, Zhina Karimi, Morteza Hadizadeh, Seyed Amir Jalali, Seyed Rouhollah Miri, Fereidoon Memari, Michael R. Hamblin
Summary: This bioinformatics analysis identified four differentially expressed circRNAs and 11 interacting miRNAs, indicating potential 1282 target genes. Among 18 hub-genes related to the survival of ccRCC patients, eight genes were found to be correlated with tumor immune cell infiltration and patient prognosis. Two potential drug candidates were suggested to play a role in ccRCC therapy.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Allergy
Kobra Mehdinejadiani, Ali Hashemi, Mojgan Bandehpour, Hoda Rahmani, Mohammad Mehdi Ranjbar, Vahid Yardel, Seyed Amir Jalali, Nariman Mosaffa
Summary: The study evaluated the immunological aspects of five peptides derived from OmpA and found their potential in preventing infections caused by A. baumannii. This suggests that peptides could be used as a promising tool for designing epitope-based vaccines against A. baumannii infections.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Elham Rostami, Mohsen Bakhshandeh, Haniyeh Ghaffari-Nazari, Maedeh Alinezhad, Masoumeh Alimohammadi, Reza Alimohammadi, Ghanbar Mahmoodi Chalbatani, Ehsan Hejazi, Thomas J. Webster, Jalil Tavakkol-Afshari, Seyed Amir Jalali
Summary: This study evaluated the effect of combining single high dose radiotherapy with an anti-CD47 monoclonal antibody in tumor-bearing mice. The combination therapy improved the immune cell population in the tumor microenvironment, suppressed tumor growth, and increased survival.
Article
Multidisciplinary Sciences
Reza Alimohammadi, Ghanbar Mahmoodi Chalbatani, Masoumeh Alimohammadi, Haniyeh Ghaffari-Nazari, Arezou Rahimi, Esmail Mortaz, Nariman Mossafa, Louis Boon, Seyed Amir Jalali
Summary: This study demonstrated that the combination therapy of FOLFOX, CD47, and PD-L1 blocking antibodies effectively increased survival and reduced tumor size in a CT-26 mouse tumor model. The triple combining regimen also resulted in a decrease in Treg and MDSC, as well as an increase in CD8+ INF-gamma+ lymphocytes and M1/M2 macrophage ratio in the tumor microenvironment. The findings suggest that this combination therapy has the potential to be translated into clinical practice.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Elham Masoumi, Asad Mirzaei, Haniyeh Ghaffari-Nazari, Sahar Tahaghoghi-Hajghorbani, Seyed Amir Jalali, Jalil Tavakkol-Afshari
Summary: This study measured serum levels of Fas/Fasl in patients with pre-eclampsia and found that sFas levels were significantly higher in patients compared to healthy pregnant women, while sFasL levels were slightly lower. The abnormality in sFas may be related to pre-eclampsia.
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Reza Zinatizadeh, Bettina Schock, Ghanbar Mahmoodi Chalbatani, Peyman Kheirandish Zarandi, Seyed Amir Jalali, Seyed Rouhollah Miri
Summary: The NF-kB transcription factor family plays a critical role in controlling important regulatory gene expression in the cellular environment, impacting processes such as immunity, inflammation, cell death, and proliferation. Understanding NF-kB function can help in the development of treatments for rare and widespread diseases.
Article
Medicine, Research & Experimental
Nazanin Biari, Seyedeh Hoda Alavizadeh, Omid Chavoshian, Azam Abbasi, Zahra Saberi, Seyed Amir Jalali, Ali Khamesipoure, Mahmoud Reza Jaafari, Ali Badiee
Summary: The study aimed to compare the effects of stable SM liposomes containing WLL with other types of vaccines in BALB/c mice. Results showed that although liposomal WLL were stable in physicochemical properties, mice receiving Liposome-WLL did not reduce footpad swelling, and the load of parasites in spleen and levels of IL-4 were higher compared to other immunized groups.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Meeting Abstract
Immunology
A. R. Nikpoor, M. R. Jaafari, P. Zamani, M. Teymouri, H. Gouklani, E. Saburi, Amiri S. Darban, A. Badiee, A. Bahramifar, M. Fasihi-Ramandi, R. A. Taheri
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Davood Mansury, Kiarash Ghazvini, Saeid Amel Jamehdar, Ali Badiee, Mohsen Tafaghodi, Amin Reza Nikpooe, Yousef Amini, Mahmoud Reza Jaafari
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)