期刊
IMMUNOLOGY LETTERS
卷 155, 期 1-2, 页码 6-10出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2013.09.021
关键词
Dendritic cells; Cancer vaccines; Immunotherapy; Lymph; Cell interactions
类别
资金
- Associazione Italiana Ricerca sul Cancro (AIRC) [IG11650]
Advances in immunobiology knowledge as well as in cell culture processes that generate large numbers of purified and functionally mature dendritic cells (DCs) have raised the possibility that DCs might represent promising clinical agents to generate effective immune responses against cancer. Here, we discuss the present pitfalls of dendritic cell vaccines for the treatment of human cancer with regard to the most recent knowledge in the biology of DCs. In particular, we highlight the relevance of improving our current understanding of DC trafficking, functions and interactions with other cells of innate immunity for the development of more effective cancer vaccines. (C) 2013 Elsevier B.V. All rights reserved.
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