期刊
IMMUNOLOGY LETTERS
卷 152, 期 1, 页码 16-24出版社
ELSEVIER
DOI: 10.1016/j.imlet.2013.03.003
关键词
HIV; NKp46; NKp30; Opportunistic infection; AIDS
类别
资金
- Istituto Superiore di Sanita (I.S.S.)
- Programma nazionale di ricerca sull' AIDS, Accordi di collaborazione scientifica [40G.41, 45G.11]
- Accordo di collaborazione scientifica [40D61, 40H69]
- Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.)
- Ministero della Salute [RF2006]
- Ricerca Oncologica-Project of Integrated Program [3/07, RF-2010-2316197]
Differences in innate immune responses may be associated with different capabilities of controlling HIV infection, not necessarily reflected by CD4(+) T-cell counts alone. We investigated by cytofluorometry the expression of NK cell receptors and ligands in 19 treated HIV-infected patients with CD4(+) <220 ml(-1) at presentation (11 AIDS, 8 non-AIDS) and 10 healthy donors. Expression of NKp46 and NKp30 was significantly higher in non-AIDS vs. AIDS patients. Overall, the level of NKp46 expression directly correlated with the degree of MR cell cytotoxicity. As compared to healthy donors, in both groups, there was a similar increase of CD69 and HLA-DR expression in NK cells that directly correlated with the presence of activation markers (HLA-DR) on CD4(+) and CD8(+) T cells. As compared to AIDS, in non-AIDS patients in vitro activated CD4(+) showed higher expression of MIC-A (NKG2D ligand), with significantly higher Nectin-2/DNAM-1 and MIC-A/NKG2D ratios. Thus, NK cell responses in AIDS and non-AIDS patients with similar CD4(+) counts significantly differ despite similar treatment. This suggests an involvement of innate mechanisms, in preventing AIDS-defining opportunistic infections in HIV infection and further suggests, that CD4(+) absolute counts alone, may be inadequate to explain differences in the clinical outcome. (C) 2013 Elsevier B.V. All rights reserved.
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