期刊
IMMUNOLOGY LETTERS
卷 147, 期 1-2, 页码 1-9出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2012.07.002
关键词
Acute liver failure; Kupffer cells; Macrophages
类别
资金
- 12-5 State Science & Technology Projects of China [2012ZX10002007]
- National Natural Science Foundation of China [81071767]
Acute liver failure (ALF) remains a worldwide problem. The innate immune system acts as an important regulator of ALF. Kupffer cells (KCs), the resident macrophages in liver, play a key role in liver innate immune response. Recent researches have shown that macrophages display a remarkable plasticity and can differentiate into functionally diverse subsets. However, the dynamic polarized phenotypes and functional status of macrophages at different stage of ALF are not clear. In this paper, we present a review of evidence that KCs play a significant role in the pathogenesis of ALF, including the phenotype and functions of macrophages, signaling pathways involved in macrophage functional status and cell-crosstalks of KCs with other immune cells. More information on macrophages will promote a better understanding of the cellular molecular mechanisms of ALF and provide new insights for the development of therapeutic targets for ALF. (C) 2012 Elsevier B.V. All rights reserved.
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