Article
Immunology
Nu Chen, Shuang Chen, Zhihui Zhang, Xuexue Cui, Lingzi Wu, Kailei Guo, Hui Shao, Jian-Xing Ma, Xiaomin Zhang
Summary: Kallistatin plays a role in promoting Th17 cell differentiation in autoimmune diseases, potentially being a key factor in exacerbating autoinflammation. Targeting Kallistatin could be a potential therapeutic strategy for treating autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: This study aimed to develop a comprehensive grading system to objectively evaluate the progression of experimental autoimmune uveitis (EAU) in mice. Weekly fundus and optical coherence tomography (OCT) images were acquired over 12 weeks, and each mouse was graded based on changes seen on both types of images. The analysis of the clinical scores showed a gradual increase in inflammatory signs in EAU mice, with most signs reaching a plateau towards the end of the study period. The development of this grading system enhances the preclinical evaluation of novel uveitis treatments.
Article
Pathology
Malihe Eskandarpour, Yi-Hsing Chen, Miles A. Nunn, Sarah E. Coupland, Wynne Weston-Davies, Virginia L. Calder
Summary: Nomacopan, derived from tick saliva, has dual functions of sequestering LTB4 and inhibiting C5 activation. Studies show therapeutic benefit of Nomacopan in experimental autoimmune uveitis, with longer-acting forms proving more efficacious.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Ophthalmology
Victor Llorenc, Yukiko Nakamura, Christina Metea, Lisa Karstens, Blanca Molins, Phoebe Lin
Summary: This study investigated the effects of antimetabolite drugs on T-cell responses and intestinal microbial composition in autoimmune uveitis. Methotrexate and mycophenolate mofetil both abrogated uveitis in the experimental autoimmune uveitis model, but had different effects on T-cell subsets and the gut microbiota composition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Immunology
Ruyi Qu, Mengxian Zhou, Yan Qiu, Yuan Peng, Xuewei Yin, Bin Liu, Hongsheng Bi, Yan'e Gao, Dadong Guo
Summary: Research has shown that glucocorticoids can modulate the balance of M1/M2 macrophage polarization through the p38MAPK-MEF2C axis in experimental autoimmune uveitis, leading to the suppression of ocular inflammation. This study elucidates the mechanism of glucocorticoids in treating uveitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Huan Li, Zhihui Zhang, Yongtao Li, Lin Su, Yanan Duan, Hui Zhang, Jinying An, Tianwen Ni, Xiaorong Li, Xiaomin Zhang
Summary: Rapa-sEVs, delivered through subconjunctival injection, show promising therapeutic effects on autoimmune uveitis by reducing ocular inflammatory cell infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sheng-Min Lo, Yih-Shiou Hwang, Chao-Lin Liu, Chia-Ning Shen, Wei-Hsin Hong, Wei-Cheng Yang, Meng-Hua Lee, Chia-Rui Shen
Summary: This study investigates the role of Toll-like receptor 7 (TLR7) in the development of experimental autoimmune uveitis (EAU). The results show that TLR7 agonist R848 exacerbates EAU progression and impairs the barrier function of retinal pigment epithelial (RPE) cells. The inhibition of TLR7 using shRNA effectively reduces disease severity. These findings highlight the immunomodulatory role of RPE TLR7 and provide a potential therapeutic strategy for autoimmune uveitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yusen Liu, Chenyang Zhao, Jiayu Meng, Na Li, Zongren Xu, Xianyang Liu, Shengping Hou
Summary: This study investigated the effect and mechanism of Galectin-3 on microglial activation and inflammation in autoimmune uveitis. The results showed that the expression of Galectin-3 was increased in microglia of uveitis retinas. Inhibition of Galectin-3 improved the clinical and pathological manifestations of uveitis and reduced the expression of proinflammatory factors. The mechanism involved down-regulation of TLR4 and MyD88 expression and inhibition of NF-kappa B p65 activation in microglia.
CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Su Pan, Handan Tan, Rui Chang, Qingfeng Wang, Ying Zhu, Lin Chen, Hongxi Li, Guannan Su, Chunjiang Zhou, Qingfeng Cao, Aize Kijlstra, Peizeng Yang
Summary: The study demonstrates that high ambient temperature exacerbates the severity of experimental autoimmune uveitis in mice, leading to an increase in Th1 and Th17 cell frequency, as well as elevated generation of neutrophil extracellular traps (NETs). These effects may be mediated by the NADPH oxidase-dependent pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: Uveitis is a complex ocular inflammatory disease that can be caused by infections or autoimmune factors. While infectious uveitis can often be resolved with anti-infective therapy and corticosteroids, non-infectious uveitis requires a better understanding of inflammatory pathways to develop more effective treatments.
DRUG DISCOVERY TODAY
(2021)
Article
Pathology
Nai-Wen Fan, Joy Li, Sharad K. Mittal, William Foulsham, Elsayed Elbasiony, Rachel M. Huckfeldt, Sunil K. Chauhan, Yihe Chen
Summary: A robust and reliable model of chronic autoimmune uveitis was successfully developed in two strains of wild-type mice by modifying drug dosage and peptide fragments. The improved method allows observation of retinal scarring and atrophy in the chronic stage, and shows an increased response of memory Th17 cells.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Shiyao Tan, Xiaojie Feng, Zhangluxi Liu, Qingfeng Wang, Qingyan Jiang, Xingsheng Ye, Hongxi Li, Guannan Su, Chunjiang Zhou, Yao Wang, Peizeng Yang
Summary: This study investigates the role of aberrant lipid metabolism in Behcet's disease and its association with the pathogenesis of autoimmune uveitis. The study reveals that triglyceride can stimulate CD4(+) T cells and its inhibition can improve the activity of uveitis.
CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
He Li, Lei Zhu, Rong Wang, Lihui Xie, Jie Ren, Shuai Ma, Weiqi Zhang, Xiuxing Liu, Zhaohao Huang, Binyao Chen, Zhaohuai Li, Huyi Feng, Guang-Hui Liu, Si Wang, Jing Qu, Wenru Su
Summary: Aging-induced changes in the immune system are associated with a higher incidence of infection and vaccination failure. In old mice, immune cell responses, especially Th17 cells, are altered, leading to a milder autoimmune response compared to young mice. This study highlights the role of GM-CSF secretion and IL-23R levels in regulating autoimmune challenges in aged mice.
Article
Biochemistry & Molecular Biology
Miao He, Dong-Ming Wu, Yang-Yang Zhao, Ye Yu, Shi-Hua Deng, Teng Liu, Ting Zhang, Jing Li, Feng Wang, Ying Xu
Summary: In this study, the effects of the autophagy activator AZD8055 on EAE were evaluated, showing that AZD8055 significantly enhanced autophagy, reduced inflammation, and inhibited pyroptosis in the spinal cords of EAE model mice. By downregulating the ROS/NLRP3 pathway, AZD8055 ameliorated EAE through anti-inflammatory and anti-pyroptosis effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Dan Li, Chang Huang, Xiaoyan Han, Jianguo Sun
Summary: This study identified novel therapeutic targets for uveitis by analyzing the transcriptome and highlighting the NOD-like receptor signaling pathway as a key player in the pathological changes of the disease.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Sarra Oumrani, Maximilien Barret, Frederic Beuvon, Carole Nicco, Charlotte Chene, Frederic Batteux, Frederic Prat
Summary: This study in a swine model demonstrated that the use of a self-assembling peptide matrix significantly reduced the incidence of esophageal stricture after circumferential endoscopic resection. Adding triamcinolone did not show significant improvement in preventing stricture formation.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Immunology
Gaetane Nocturne, Bineta Ly, Audrey Paoletti, Juliette Pascaud, Raphaele Seror, Carole Nicco, Fabienne Mackay, F. B. Vincent, Thierry Lazure, Sophie Ferlicot, Lev Stimmer, Quentin Pascal, Sandrine Roulland, Roman Krzysiek, Salima Hacein-Bey, Frederic Batteux, Xavier Mariette
Summary: This study found that prolonged treatment with monoclonal anti-TNF antibodies increases the risk of lymphoma in patients with B cell-driven autoimmune diseases, suggesting closer monitoring for lymphoma development in these patients with long-term exposure to monoclonal anti-TNF antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Cell Biology
Yipu Dang, Camille Souchet, Fabiana Moresi, Mohamed Jeljeli, Bruno Raquillet, Carole Nicco, Sandrine Chouzenoux, Isabelle Lagoutte, Louis Marcellin, Frederic Batteux, Ludivine Doridot
Summary: Trained immunity, a concept where innate immune cells undergo long-term metabolic and epigenetic reprogramming, can impact pregnancy outcomes by altering the leukocyte population profile at the maternal-fetal interface and influencing fetal growth and development. In this study, preconceptional infections-induced trained immunity led to fetal growth restriction, thereby suggesting a potential link between immune training and pregnancy outcomes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Catherine Argyriou, Anna Polosa, Ji Yun Song, Samy Omri, Bradford Steele, Bruno Cecyre, Devin S. McDougald, Erminia Di Pietro, Jean-Francois Bouchard, Jean Bennett, Joseph G. Hacia, Pierre Lachapelle, Nancy E. Braverman
Summary: This study evaluated PEX1 retinal gene augmentation therapy in a mouse model of Zellweger spectrum disorder, showing partial normalization of peroxisomal metabolic functions and significantly improved retinal response after therapeutic vector treatment. These results suggest the potential for retinal gene delivery to improve vision in patients with peroxisome biogenesis disorders.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Review
Medicine, Research & Experimental
Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor, Jaroslaw Bilinski, Elisabetta Caselli, Elena M. Comelli, Markus Egert, Cristina Giaroni, Tomasz M. Karpinski, Igor Loniewski, Agata Mulak, Julie Reygner, Paulina Samczuk, Matteo Serino, Mariusz Sikora, Annalisa Terranegra, Marcin Ufnal, Romain Villeger, Chantal Pichon, Peter Konturek, Marvin Edeas
Summary: The human gastrointestinal tract is home to a large microbial community called gut microbiota, which plays important roles in immune function, nutrient absorption, and protection against pathogens. The interaction between gut microbiota and various organs within the human body is bidirectional, and microbial alteration has been shown to be a key factor in the pathogenesis of many diseases. Understanding the mechanisms behind gut microbial symbiosis/dysbiosis is crucial for clinical and health fields.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Philippe A. Grange, Guillaume Ollagnier, Laurianne Beauvais Remigereau, Carole Nicco, Constance Mayslich, Anne-Genevieve Marcelin, Vincent Calvez, Nicolas Dupin
Summary: Acne is a chronic inflammatory disease caused by Cutibacterium acnes (C. acnes) bacteria. The current treatments for acne often have adverse effects. However, the study found that meclozine, an anti-histaminic H1 compound, has anti-inflammatory properties. In vitro and in vivo experiments showed that meclozine can reduce inflammation caused by C. acnes and decrease the production of inflammatory cytokines. Clinical trials also demonstrated that meclozine gel can effectively reduce acne severity without any adverse events.
Article
Immunology
Charlotte Chene, Mohamed Maxime Jeljeli, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Frederic Batteux, Carole Nicco
Summary: This study aimed to enhance the clearance of activated immune cells by combining arsenic trioxide (ATO) with a divalent cation to generate a Fenton reaction. In vitro experiments showed that the combination of ATO and copper chloride induced high levels of oxidative stress. In vivo experiments using a mouse model of GvHD demonstrated that the co-treatment effectively reduced lymphocyte activation and fibrosis, suggesting a potential treatment for GvHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Carole Nicco, Marine Thomas, Julie Guillermet, Maryline Havard, Fanny Laurent-Tchenio, Ludivine Doridot, Francois Dautry, Frederic Batteux, Thierry Tchenio
Summary: Self-sustained quiescence (SSQ) is a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. It has been found that low cell density and the use of drugs can induce cells into SSQ state. In SSQ state, the tumor growth rate of pancreatic adenocarcinoma cells slows down, but eventually transitions to a rapid growth phase. Identifying new agents targeting cancer cells in SSQ may improve patient survival.
Article
Biochemistry & Molecular Biology
Caroline Prieux-Klotz, Henri Chedotal, Martha Zoumpoulaki, Sandrine Chouzenoux, Charlotte Chene, Alvaro Lopez-Sanchez, Marine Thomas, Priya Ranjan Sahoo, Clotilde Policar, Frederic Batteux, Helene C. Bertrand, Carole Nicco, Romain Coriat
Summary: A new prodrug combining a Mn SOD mimic with oxaliplatin was designed and studied for its antitumoral effects. In vitro and in vivo experiments showed that this combination treatment increased ROS production, improved antitumoral efficacy, and decreased oxaliplatin-induced peripheral neuropathy without impairing the overall clinical tolerance to oxaliplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Maximilien Barret, Ludivine Doridot, Morgane Le Gall, Frederic Beuvon, Sebastien Jacques, Anna Pellat, Arthur Belle, Einas Abou Ali, Marion Dhooge, Sarah Leblanc, Marine Camus, Carole Nicco, Romain Coriat, Stanislas Chaussade, Frederic Batteux, Frederic Prat
Summary: Our study aimed to identify transcripts specifically overexpressed or repressed in patients who developed post-endoscopic esophageal stricture, as potential targets for stricture prevention. Transcriptomic analysis revealed activation of the interleukin (IL)-1 group and inhibition of interferon-gamma (INF gamma) and NUPR1 in the stricture group on Day 14, but these differences were no longer significant on Day 90.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Immunology
Charlotte Chene, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Carole Nicco, Frederic Batteux
Summary: In this study, the combination of arsenic trioxide (ATO) and copper chloride (CuCl2) was used to treat a mouse model of systemic sclerosis (SSc). The results showed that the combination treatment could achieve the same therapeutic effect as a high dose of ATO alone, while reducing the dosage of ATO and improving the health status of the mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Deepika Raman, Charlotte Chene, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Veronique Clement, Frederic Batteux, Shazib Pervaiz
Summary: Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). A pilot study on a murine model of sclerodermatous cGVHD showed that treatment with the senolytic combination of dasatinib and quercetin (DQ) significantly improved physical and tissue-specific features associated with cGVHD pathogenesis. The study suggests the involvement of senescent cells in cGVHD and highlights the potential therapeutic strategy of using DQ.
Article
Immunology
Anderson Rodrigues de Almeida, Andrea Tavares Dantas, Maria Eduarda de Oliveira Goncalves, Charlotte Chene, Mohamed Jeljeli, Sandrine Chouzenoux, Marine Thomas, Eudes Gustavo Constantino Cunha, Lilian David de Azevedo Valadares, Joao Victor de Melo Gomes, Simao Kalebe Silva de Paula, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Michelly Cristiny Pereira, Angela Luzia Branco Pinto Duarte, Dulcineia Saes Parra Abdalla, Carole Nicco, Frederic Batteux, Maira Galdino da Rocha Pitta
Summary: This study aimed to investigate the immunomodulatory and antifibrotic properties of a TZD derivative called LPSF/GQ-16 in peripheral blood mononuclear cells (PBMC) from SSc patients and in a murine model of SSc. The results showed that LPSF/GQ-16 modulated the secretion of cytokines and significantly reduced dermal fibrosis in the mouse model. This study suggests the therapeutic potential of LPSF/GQ-16 for SSc.
INFLAMMOPHARMACOLOGY
(2023)
Article
Rheumatology
Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphael Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frederic Batteux, Jerome Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon, Yannick Allanore
Summary: This study investigates the efficacy of acazicolcept in mouse models of systemic sclerosis (SSc) and finds that it can reduce fibrosis and alleviate pulmonary hypertension.
ARTHRITIS RESEARCH & THERAPY
(2022)
Meeting Abstract
Dermatology
Philippe Alain Grange, Guillaume Ollagnier, Carole Nicco, Philippe Morand, Anne-Genevieve Marcelin, Vincent Calvez, Nicolas Dupin
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)