Review
Cardiac & Cardiovascular Systems
Zahra Hajializadeh, Mohammad Khaksari
Summary: Cardiac hypertrophy (CH) is a major cause of morbidity and mortality worldwide, leading to heart failure. Sex differences in CH may be caused by sex hormones or their receptors, with the incidence increasing in postmenopausal women due to the decrease in female sex hormone 17-beta estradiol (E2). E2 and its receptors inhibit CH, while Silent information regulator 1 (SIRT1) plays a crucial role in biological processes and has a protective effect against CH.
HEART FAILURE REVIEWS
(2022)
Article
Cell Biology
Ilaria Campesi, Andrea Montella, Flavia Franconi
Summary: Monocytes play a critical role in inflammation and immune response, and their activity is sex-dependent. The study found that LPS treatment led to qualitative and quantitative sex differences in monocytes, with differences in autophagy, TNF-alpha release, chemotaxis, and estrogen receptor expression between male and female cells. These results indicate that sex plays a significant role in regulating monocytes' functions in a cell- and parameter-specific manner.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Aylin Del Moral-Morales, Juan Carlos Gonzalez-Orozco, Ana Maria Hernandez-Vega, Karina Hernandez-Ortega, Karla Mariana Pena-Gutierrez, Ignacio Camacho-Arroyo
Summary: A study found that in human Glioblastomas (GBM), the pro-oncogenic actions of 17 beta-estradiol (E2) are mediated by EZH2, which promotes proliferation, migration, and invasion of GBM cells. Although E2 does not modify EZH2 expression, gene silencing and pharmacological inhibition of EZH2 can block these pro-oncogenic actions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Hongwei Duan, Junjie Hu, Longfei Xiao, Jianshu Lv, Yong Zhang, Xingxu Zhao
Summary: In sheep granulosa cells (GCs), the production of melatonin was inhibited by E2 through an ERA and ERB-mediated process, which also affected the expression of melatonin receptors.
Article
Psychiatry
E. E. Redei, J. D. Ciolino, S. L. Wert, A. Yang, S. Kim, C. Clark, K. B. Zumpf, K. L. Wisner
Summary: The study found that transcriptomic biomarkers in blood are associated with depressive symptoms in women during pregnancy and postpartum, with some markers influenced by estrogen and progesterone. These results suggest that blood biomarkers may aid in identifying depressive symptoms in pregnant women.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Xiuting Xiang, LiangZhen Xie, Jieqi Lin, Rahmawati Pare, Guanshen Huang, Jianming Huang, Yuyan Wang, Shicong Song, Yunjun Ruan
Summary: Atherosclerosis, a major cause of cardiovascular diseases, is mainly caused by vascular endothelial cell (VECs) senescence. It has been shown that 17 beta-estradiol (17 beta-E-2) can protect VECs from senescence by activating autophagy, but the underlying mechanism is still unclear. This study aims to investigate the role of estrogen receptor (ER) alpha and beta in the effects of 17 beta-E-2 on vascular autophagy and aging using in vitro and in vivo models.
Article
Neurosciences
Erin E. Maher, Paula F. Overby, Amanda H. Bull, Joshua S. Beckmann, Jonna M. Leyrer-Jackson, Stephanie Koebele, Heather A. Bimonte-Nelson, Cassandra D. Gipson
Summary: This study found that women have more difficulty quitting smoking and currently available treatments are less effective for women. Fluctuations in ovarian hormones across the menstrual cycle can affect craving and smoking relapse propensity. Natural and synthetic estrogens play a critical role in mediating the neurobehavioral effects of nicotine.
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Oncology
Tiziana Triulzi, Viola Regondi, Elisabetta Venturelli, Patrizia Gasparini, Cristina Ghirelli, Jessica Groppelli, Martina Di Modica, Francesca Bianchi, Loris De Cecco, Lucia Sfondrini, Elda Tagliabue
Summary: HER2 mRNA expression is associated with the response to anti-HER2 treatment and is independent of estrogen receptor tumor status in HER2-positive breast cancer patients. HER2 mRNA levels can predict the risk and exhibit distinct biological characteristics compared to HER2 protein levels.
Article
Biochemistry & Molecular Biology
Sugandha Gupta, Mengya Wang, Yoshiaki Azuma, Nancy A. Muma
Summary: This study reveals two mechanisms regulating SUMOylation of 5-HT1ARs, by agonists and EB, and two key enzymes, PIASx alpha and SENP2, involved in this process. The findings demonstrate that these mechanisms differ based on treatment with agonists and EB. Targeting the SUMOylation of 5-HT1ARs could have important clinical relevance for the therapy of several neuropsychiatric disorders involving 5-HT1ARs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Stephanie Chauvin, Joelle Cohen-Tannoudji, Celine J. Guigon
Summary: This review provides a comprehensive overview of the role of E2 in female folliculogenesis and the various effects of ERβ splice isoforms. It also discusses how deregulation of E2 signaling can lead to two ovarian pathologies and emphasizes the need for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Dandan Song, Huan He, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Indranil Sinha, Lars-Arne Haldosen, Chunyan Zhao, Cecilia Williams
Summary: This study investigates the differences between estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in regulating cell proliferation and migration. The results show that ERα and ERβ have opposite effects on cell proliferation and different impacts on migration. Furthermore, they regulate distinct sets of target genes, providing valuable insights into the mechanisms of these two different ER isoforms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Morgane Davezac, Cecile Meneur, Melissa Buscato, Rana Zahreddine, Jean-Francois Arnal, Florence Dalenc, Francoise Lenfant, Coralie Fontaine
Summary: Breast cancer is the most common cancer in women, but advancements in cancer detection and treatment have improved survival rates. However, cardiovascular diseases have become a significant cause of long-term morbidity and mortality in breast cancer survivors due to the cardiovascular toxicity of cancer treatments. There is debate regarding the impact of endocrine therapies, particularly tamoxifen, on cardiovascular diseases in breast cancer patients.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Neurosciences
Muthuvel Jayachandran, Virginia M. Miller, Brian D. Lahr, Kent R. Bailey, Val J. Lowe, Julie A. Fields, Michelle M. Mielke, Kejal Kantarci
Summary: This study found an association between specific markers in blood microvesicles, summarized into two principal components, and brain amyloid-beta deposition in menopausal women. This suggests the feasibility of diagnosing and predicting Alzheimer's disease and related dementias at the population level.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Endocrinology & Metabolism
Erzsebet Kovesdi, Ildiko Udvaracz, Angela Kecskes, Szilard Szocs, Szidonia Farkas, Peter Faludi, Tibor Z. Janosi, Istvan M. Abraham, Gergely Kovacs
Summary: In this study, the acute effect of 17 beta-estradiol on the function of striatal cholinergic neurons in adult mice was examined in vitro. The expression of estrogen receptors ER alpha, ER beta, and GPER1 mRNA was found to be low in some striatal cholinergic neurons. High dose of 17 beta-estradiol affected the spontaneous firing rate of these neurons only in old males, while low concentration did not show any acute effect or association with estrus cycle or sex.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Maria Giovanna Scioli, Gabriele Storti, Alessandra Bielli, Massimo Sanchez, Manuel Scimeca, Jeffrey M. Gimble, Valerio Cervelli, Augusto Orlandi
Summary: The study reveals the crucial role of CD146 in ASC properties and osteochondrogenic commitment, with CD146(+) ASCs showing superior chondrogenic potential and CD146(-) ASCs demonstrating greater osteogenic capacity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Maria Antonietta Oliva, Salvatore Castaldo, Rossella Rotondo, Sabrina Staffieri, Massimo Sanchez, Antonietta Arcella
Summary: The study demonstrates that p-Coumaric acid (pCA) has potential anticancer activity in treating glioblastoma by inducing cell cycle arrest and apoptosis, affecting cell growth and viability of U87Mg cells.
JOURNAL OF CHEMOTHERAPY
(2022)
Article
Virology
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Patrizia Leone, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Massimo Sanchez, Andrea Cara, Zuleika Michelini, Maurizio Federico
Summary: Engineered extracellular vesicles can induce a potent SARS-CoV-2 CD8(+) T cell immune response and generate long-lasting lung-specific immune memory. This immunization approach is significant in addressing the limitations of current anti-SARS-CoV-2 vaccines.
Article
Rheumatology
Serena Colafrancesco, Cristiana Barbati, Roberta Priori, Erisa Putro, Federico Giardina, Angelica Gattamelata, Benedetta Monosi, Tania Colasanti, Alessandra Ida Celia, Bruna Cerbelli, Carla Giordano, Susanna Scarpa, Massimo Fusconi, Giulio Cavalli, Onorina Berardicurti, Saviana Gandolfo, Saba Nayar, Francesca Barone, Roberto Giacomelli, Salvatore De Vita, Cristiano Alessandri, Fabrizio Conti
Summary: Autophagy plays a crucial role in the activation of salivary gland epithelial cells (SGECs) in the pathogenesis of primary Sjogren's syndrome (SS). Autophagy activation is correlated with histologic severity and has been confirmed in both in vitro and in vivo experiments. Therefore, autophagy may serve as a new therapeutic target for primary SS.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Cell Biology
Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti
Summary: This study investigates the impact of Belimumab (BLM) on autophagy and citrullination, finding that BLM treatment can decrease autophagy and citrullination levels in patients with SLE, as well as affect IL-18 concentration.
Article
Biochemistry & Molecular Biology
Manuele Gori, Sara Maria Giannitelli, Gianluca Vadala, Rocco Papalia, Loredana Zollo, Massimo Sanchez, Marcella Trombetta, Alberto Rainer, Giovanni Di Pino, Vincenzo Denaro
Summary: The organic zwitterionic-poly(sulfobetaine methacrylate) [poly(SBMA)]-hydrogel has been demonstrated as an effective coating to reduce foreign-body reaction caused by intraneural electrodes. This hydrogel exhibits low fouling characteristics and can be successfully coated on Polyimide surfaces through covalent bonds, showing potential for long-term release of anti-fibrotic drugs. Its properties make it a promising diffusion-based delivery system for slow and controlled anti-inflammatory and anti-fibrotic drug release in vivo.
Review
Biochemistry & Molecular Biology
Maria Raza Tokatli, Leuconoe Grazia Sisti, Eleonora Marziali, Lorenza Nachira, Maria Francesca Rossi, Carlotta Amantea, Umberto Moscato, Walter Malorni
Summary: This article provides a broad review of the role of hormone regulation in gender medicine and gender differences across key clinical areas. The study highlights the influence of sex differences in immune response, cardiovascular diseases, neurological disorders, cancer, and COVID-19. It also emphasizes the importance of gender implications in occupational health and health policy, calling for more personalized clinical medicine and public health approaches.
Review
Clinical Neurology
Maria Francesca Rossi, Antonio Tumminello, Matteo Marconi, Maria Rosaria Gualano, Paolo Emilio Santoro, Walter Malorni, Umberto Moscato
Summary: Gender medicine is a new medical approach that studies the differences between women and men in terms of prevention, diagnosis, and the outcome of diseases. Migraines, the most common neurological illness, have a higher prevalence in women than in men. They have a significant impact on the psychophysical health and productivity of workers.
NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Massimo Sanchez, Maurizio Federico
Summary: This study proposes an innovative strategy for anti-SARS-CoV-2 immune response using extracellular vesicles (EVs). By fusing SARS-CoV-2 N with Nef(mut) or a deletion mutant of Nef(mut), the researchers successfully induced immune responses in human cells. The findings demonstrate the potential of engineered EVs to elicit a strong immune response in human cells.
Article
Biochemistry & Molecular Biology
Tania Colasanti, Katia Stefanantoni, Cristina Fantini, Clarissa Corinaldesi, Massimiliano Vasile, Francesco Marampon, Luigi Di Luigi, Cristina Antinozzi, Paolo Sgro, Andrea Lenzi, Valeria Riccieri, Clara Crescioli
Summary: The study analyzed the effect of the prostacyclin analogue iloprost on CXCL10 secretion in endothelial cells and fibroblasts, as well as in the serum of systemic sclerosis (SSc) patients. The results showed that iloprost could target CXCL10, preventing its release and potentially improving SSc. Further research is needed to better understand and manage SSc using iloprost.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Alessio Lanna, Bruno Vaz, Clara D'Ambra, Salvatore Valvo, Claudia Vuotto, Valerio Chiurchiu, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Arne N. Akbar, Marco De Bardi, Derek W. Gilroy, Michael L. Dustin, Brendan Blumer, Michael Karin
Summary: It was discovered that some T cells can elongate telomeres by acquiring telomere vesicles from antigen-presenting cells, independently of telomerase action, which contributes to delaying the aging process.
NATURE CELL BIOLOGY
(2022)
Article
Immunology
Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim, Michele Signore, Marco Pietrosanto, Manuela Helmer-Citterich, Matteo Pallocca, Maurizio Fanciulli, Tiziana Bruno, Francesca De Nicola, Giacomo Corleone, Anna Di Benedetto, Cristiana Ercolani, Edoardo Pescarmona, Laura Pizzuti, Francesco Guidi, Francesca Sperati, Sara Vitale, Daniele Macchia, Massimo Spada, Giovanna Schiavoni, Fabrizio Mattei, Adele De Ninno, Luca Businaro, Valeria Lucarini, Laura Bracci, Eleonora Arico, Giovanna Ziccheddu, Francesco Facchiano, Stefania Rossi, Massimo Sanchez, Alessandra Boe, Mauro Biffoni, Ruggero De Maria, Ilio Vitale, Antonella Sistigu
Summary: The study demonstrates that type I interferons can promote the formation of cancer stem cells by upregulating the chromatin remodeling factor KDM1B. Inhibition of KDM1B could potentially prevent stem cell expansion and increase the long-term benefit of therapy.
Article
Environmental Sciences
Danilo Buonsenso, Maria Rosaria Gualano, Maria Francesca Rossi, Angelica Valz Gris, Leuconoe Grazia Sisti, Ivan Borrelli, Paolo Emilio Santoro, Antonio Tumminello, Carolina Gentili, Walter Malorni, Piero Valentini, Walter Ricciardi, Umberto Moscato
Summary: This study investigates the impact of COVID-19 sequelae on workers' occupational status and identifies smoking as a risk factor for workers not being able to resume their job. It emphasizes the need for close monitoring of mental health, especially in female workers, after COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cell Biology
Daniela Peruzzu, Zaira Boussadia, Federica Fratini, Francesca Spadaro, Lucia Bertuccini, Massimo Sanchez, Maria Carollo, Paola Matarrese, Mario Falchi, Francesca Iosi, Carla Raggi, Isabella Parolini, Alessandra Care, Massimo Sargiacomo, Maria Cristina Gagliardi, Katia Fecchi
Summary: In this study, the role of cholesterol transport in the endosomal degradative-secretory system was explored using the U18666A inhibitor in a metastatic human melanoma cell line (WM266-4). The results showed that U18666A induced a shift of Cav-1 from the plasma membrane to the endolysosomal compartment, affecting the formation and release of small extracellular vesicles (sEVs). The inhibitor also altered the protein composition of sEVs and reduced their transfer capacity on target cells.
Article
Medicine, General & Internal
Alessio Molfino, Ottavio Martellucci, Michele Melena, Eleonora Assanto, Antonello Giovannetti, Maurizio Muscaritoli
INTERNAL AND EMERGENCY MEDICINE
(2023)