Article
Biochemistry & Molecular Biology
Sabina Kaczanowska, Daniel W. Beury, Vishaka Gopalan, Arielle K. Tycko, Haiying Qin, Miranda E. Clements, Justin Drake, Chiadika Nwanze, Meera Murgai, Zachary Rae, Wei Ju, Katherine A. Alexander, Jessica Kline, Cristina F. Contreras, Kristin M. Wessel, Shil Patel, Sridhar Hannenhalli, Michael C. Kelly, Rosandra N. Kaplan
Summary: By utilizing genetically engineered myeloid cells to deliver IL-12, immune suppression in the premetastatic niche can be reversed, resulting in improved survival and reduced metastatic and primary tumor burden in tumor-bearing mice.
Article
Immunology
Shudong Liu, Jie Wang, Wenyan Li, Hui Shi, Changlong Zhou, Ge Tang, Jiangwei Zhang, Zhao Yang
Summary: The study showed that immune suppression of allogeneic CD4+ or CD8+ T cells can be induced by TIPE-2 transduced dendritic cells, leading to reduced T cell proliferation, cytokine production, and activation marker levels. These results suggest that TIPE-2 transduced DCs could be a promising approach for therapeutic strategies in transplantation or autoimmune diseases.
JOURNAL OF INFLAMMATION-LONDON
(2021)
Article
Medicine, Research & Experimental
Katsunori Endo, Rina Matsui, Takuya Asami, Toko Sawa, Akane Nakashima, Yuuri Tanaka, Hidefumi Makabe, Sachi Tanaka
Summary: PCB2DG from grape seeds suppresses the production of IL-17, TNF-alpha, IL-1 beta, and IL-6 by modulating transcription factors expression and cytokine secretion, providing a novel mechanism for the immunosuppressive effects of polyphenols.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Keunok Jung, You-kyoung Jeon, Dae Hoon Jeong, Jung Mi Byun, Bjarne Bogen, Inhak Choi
Summary: The study identified VSIG4-expressing tumor-associated macrophages (TAMs) as negative regulators of anti-tumor immunity in the tumor microenvironment. These TAMs suppress T cell proliferation, cytokine production, and the cytotoxicity of CD8 thorn T cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
David Hongo, Pingping Zheng, Suparna Dutt, Rahul D. Pawar, Everett Meyer, Edgar G. Engleman, Samuel Strober
Summary: Classical dendritic cells (cDCs) in mice can be divided into DC1 and DC2 subsets based on the expression of nuclear transcription factors, with DC1 further divided into DC1a and DC1b subsets. DC1b and DC2 cells pulsed with OVA protein are more effective in reducing melanoma growth compared to DC1a cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Seokhyeong Go, Mungyo Jung, Suyoung Lee, Sangjun Moon, Jihye Hong, Cheesue Kim, Yeonseok Chung, Byung-Soo Kim
Summary: A therapeutic cancer nanovaccine has been developed that enhances T cell responses by interacting with both dendritic cells (DCs) and T cells. This nanovaccine, named CCM-MPLA-aCD28, activates tumor-specific CD8+ T cells and exhibits a higher antitumor efficacy compared to nanovaccines that interact with either DCs or T cells.
ADVANCED MATERIALS
(2023)
Article
Nutrition & Dietetics
Adrian D. Friedrich, Juliana Leoni, Mariela L. Paz, Daniel H. Gonzalez Maglio
Summary: Lipoteichoic acid (LTA) from different Gram-positive bacterial sources has varying immune effects. Lacticaseibacillus rhamnosus GG LTA (LGG-LTA) oral administration reduces UVB-induced immunosuppression and skin tumor development in mice. In this study, the immunomodulatory effects of LGG-LTA on dendritic cells (DC) and T cells were evaluated in vitro and in the gut-associated lymphoid tissue (GALT). The results showed that LGG-LTA activated DC and T cells, promoting Th1-biased immune response after oral LTA administration.
Article
Immunology
Durga Reddi, Lydia Durant, David Bernardo, Alistair Noble, Nicholas R. English, Philip Hendy, Graeme C. Clark, Joann L. Prior, Ethel Diane Williamson, Stella C. Knight
Summary: The study demonstrated the in vitro priming of naïve human T cells against heat-killed B. pseudomallei by co-culturing with syngeneic, pulsed dendritic cells. Myeloid DCs showed a major response to B. pseudomallei, contributing significantly to the expression of migration marker CCR7 and secretion of proinflammatory cytokines TNF alpha and IL1 beta. The study suggests that this approach could be used to screen for human cellular response to candidate vaccines and enhance cell-mediated immunity against intracellular pathogens.
Article
Biochemistry & Molecular Biology
Tamara Saksida, Bojan Jevtic, Neda Djedovic, Dorde Miljkovic, Ivana Stojanovic
Summary: Autoimmune diseases are on the rise in western societies, with increasing focus on the role of reactive oxygen species (ROS) in immune response modulation. Recent studies highlight the importance of ROS in the function of dendritic cells (DC) and T cells. However, the effectiveness of ROS modulation in directing T cells and DCs towards a tolerogenic phenotype remains unclear. The potential use of ROS modulation to enhance the regulatory properties of DC and Treg in cell-based immunotherapy also requires further clarification for future therapeutic applications.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Sarah Y. Ebstein, Ashique Rafique, Yi Zhou, Amanda Krasco, Welby Montalvo-Ortiz, Lola Yu, Luisaidy Custodio, Rene C. Adam, Nicolin Bloch, Ken Lee, Funmilola Adewale, Dominic Vergata, Antonio Luz, Sebastien Coquery, Benjamin Daniel, Erica Ullman, Matthew C. Franklin, Aynur Hermann, Tammy Huang, William Olson, Samuel Davis, Andrew J. Murphy, Matthew A. Sleeman, Joyce Wei, Dimitris Skokos
Summary: VSIG4 is a complement receptor expressed on tissue resident macrophages and is involved in immune function. This study identifies heparan sulfates as novel binding partners of VSIG4 and suggests a role for them in immune modulation. Heparan sulfates compete with known VSIG4 binding partners and may play a role in the complex regulation of VSIG4 in the immune system.
Article
Immunology
H. Hackstein, A. Kalina, B. Dorn, I. S. Keil, N. Baal, G. Michel, C. Brendel, A. Neubauer, T. Jakob, G. Bein
Summary: Extracorporeal photopheresis (ECP) acts through antigen-presenting dendritic cells (DC) and is influenced by CD11c(+) DC, demonstrating antigen specificity and showing the critical importance of CD11c(+) DC for ECP activity.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel F. Zegarra-Ruiz, Dasom V. Kim, Kendra Norwood, Myunghoo Kim, Wan-Jung H. Wu, Fatima B. Saldana-Morales, Andrea A. Hill, Shubhabrata Majumdar, Stephanie Orozco, Rickesha Bell, June L. Round, Randy S. Longman, Takeshi Egawa, Matthew L. Bettini, Gretchen E. Diehl
Summary: Humans and their microbiota have a mutually beneficial relationship, where microbiota provides nutritional benefits and protection, and humans provide a hospitable environment. Maintaining this relationship requires immune balance to contain commensal microorganisms and limit inflammatory responses. Intestinal microorganisms can be recognized by T cells with antigen-specificity.
Article
Multidisciplinary Sciences
G. Rizzuto, J. F. Brooks, S. T. Tuomivaara, T. I. McIntyre, S. Ma, D. Rideaux, J. Zikherman, S. J. Fisher, A. Erlebacher
Summary: The recognition and tolerance of the placenta by the maternal immune system is crucial for a healthy pregnancy. This study provides evidence that glycan-mediated B cell suppression plays a key role in establishing fetomaternal tolerance in mice. The release of trophoblast-derived sialoglycoproteins into the maternal circulation during pregnancy suggests potential implications for immune-mediated pregnancy complications and tumor immune evasion.
Article
Biology
Jennifer Connors, David Joyner, Nathan J. J. Mege, Gina M. M. Cusimano, Matthew R. R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. M. Kim, Paulo J. C. Lin, Ying K. K. Tam, Drew Weissman, Michele A. A. Kutzler, Mohamad-Gabriel Alameh, Elias K. K. Haddad
Summary: The role of empty lipid nanoparticles (eLNP) in dendritic cell maturation and innate immune signaling is impaired in older adults, leading to lower immune responses to SARS-CoV-2 mRNA-based vaccines. eLNP can induce maturation of monocyte derived dendritic cells (MDDCs) and upregulate CD40 expression and cytokine production in multiple DC subsets and monocytes. However, healthy older adults (>65 yrs) exhibit decreased CD40 expression, IFN-gamma output, and dysregulated anti-viral signaling response to eLNP stimulation, including defective type I IFN production and phagocytosis.
COMMUNICATIONS BIOLOGY
(2023)
