期刊
IMMUNOLOGY LETTERS
卷 131, 期 2, 页码 107-112出版社
ELSEVIER
DOI: 10.1016/j.imlet.2010.04.002
关键词
Adaptive immunity; Innate immunity; T cells; NK cells; Inflammation; Activation; Effector response
类别
资金
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- Center for Cancer Research, National Cancer Institute, National Institutes of Health
The mechanisms by which the immune system responds to an infection or disease depend on a complex interplay between the elements of innate and adaptive immunity. While most of the focus so far has been on the innate instruction of the adaptive immune responses, considerable evidence now suggests an equally important adaptive control of the innate immunity. Several studies yield new insights into how the adaptive immunity by initiating an antigen-specific response can compensate, suppress and activate innate responses at the site of tissue antigen. Here we discuss recent advances in our understanding of the adaptive control of immune effector functions in various pathological and physiological conditions. (C) 2010 Elsevier B.V. All rights reserved.
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