Article
Chemistry, Applied
Meng Xu, Xiaoling Chen, Zhiqing Huang, Daiwen Chen, Mingzhou Li, Jun He, Hong Chen, Ping Zheng, Jie Yu, Yuheng Luo, Bing Yu
Summary: The study found that dietary grape seed proanthocyanidin extract (GSPE) supplementation can improve meat quality, muscle fiber characteristics, and antioxidant capacity in finishing pigs. By increasing certain nutrient content and promoting specific protein expressions, GSPE enhances the overall nutritional value of pork.
Article
Fisheries
Yaser Mohammadi, Barzan Bahrami Kamangar, Mohammad Ali Zarei
Summary: The study evaluated the effects of grape seed proanthocyanidin extract on growth performance, serum biochemical properties, fillet proximate composition, and liver antioxidant enzyme activity in common carp fingerlings. The results showed dose-dependent effects of GSPE on various parameters, with low levels showing positive impacts.
Article
Biochemistry & Molecular Biology
Romina M. Rodriguez, Marina Colom-Pellicer, Jordi Blanco, Enrique Calvo, Gerard Aragones, Miquel Mulero
Summary: This study found that seasonal variations have an impact on hepatic glucose and lipid metabolism, suggesting a potential relationship with metabolic diseases. Furthermore, the consumption of procyanidin may modulate the photoperiod-dependent changes in glucose and lipid metabolism.
Article
Food Science & Technology
Ivan Escobar-Martinez, Veronica Arreaza-Gil, Begona Muguerza, Anna Arola-Arnal, Francisca Isabel Bravo, Cristina Torres-Fuentes, Manuel Suarez
Summary: This study found that circadian rhythms, diet, and gender are key factors influencing the bioavailability of phenolic compounds.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Physical
Dan-Yang Wang, Bo-Li Nie, Hui-Jing Li, Wei-Wei Zhang, Yan-Chao Wu
Summary: The mixture of GSPE and Tween-80 as an eco-friendly corrosion inhibitor shows excellent inhibition performance for mild steel in 1M hydrochloric acid, with the inhibitory effect verified through various experimental methods. The study found that this mixture can enhance the corrosion inhibition of mild steel, achieving an inhibition rate of 96.48%, and the mechanism of action was determined through adsorption isotherms and surface analysis.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Agriculture, Dairy & Animal Science
Yadi Feng, Xiaoling Chen, Daiwen Chen, Jun He, Ping Zheng, Yuheng Luo, Bing Yu, Zhiqing Huang
Summary: Grape seed proanthocyanidin extract (GSPE) improves antioxidant capacity and lipid metabolism in finishing pigs, as shown by increased levels of glutathione and high-density lipoprotein cholesterol, and reduced levels of malondialdehyde, triglyceride, and total cholesterol. GSPE also activated the AMPK signal and upregulated the expression of lipolysis- and fatty acid oxidation-related genes, while downregulating lipogenesis-related genes.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonio J. Cortes-Espinar, Nestor Ibarz-Blanch, Jorge R. Soliz-Rueda, Enrique Calvo, Francisca Isabel Bravo, Miquel Mulero, Javier Avila-Roman
Summary: Disruptions of the light/dark cycle and unhealthy diets can lead to oxidative stress. Grape seed proanthocyanidin extract (GSPE) has antioxidant properties and has shown positive effects in regulating circadian disruptions. This study examined the impact of GSPE administration on the liver oxidant system of rats undergoing a sudden photoperiod shift. The results indicate that GSPE improved the antioxidant response under specific photoperiod conditions, suggesting its potential in treating circadian-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonio J. Cortes-Espinar, Nestor Ibarz-Blanch, Jorge R. Soliz-Rueda, Beatrice Bonafos, Christine Feillet-Coudray, Francois Casas, Francisca Isabel Bravo, Enrique Calvo, Javier Avila-Roman, Miquel Mulero
Summary: Polyphenols play a key role in regulating circadian rhythms, while the cafeteria diet disrupts liver biological rhythm and increases ROS production. This study investigated the effects of grape seed proanthocyanidin extract (GSPE) on restoring the antioxidant balance and circadian rhythm in rats fed a cafeteria diet. GSPE treatment recovered the disrupted circadian rhythm, increased the peak expression of Sod1, and corrected altered hepatic metabolites. The timing of GSPE administration also showed a chronotherapeutic effect on its antioxidant properties.
Article
Oncology
Ka-Na Lin, Wei Zhao, Shi-Ying Huang, Hao Li
Summary: The study revealed that GSPE inhibits the proliferation of HL-60/ADR cells through induction of apoptosis in a dose-dependent manner via the Bax/Bcl-2 caspase-3/9 signaling pathway.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sanna Rajasekhar, Muthangi V. V. Subramanyam, Sambe Asha Devi
Summary: This study suggests that the combination of GSPE and INS can effectively reduce oxidative stress and pancreatic degeneration in T1DM rats, and improve the number of beta cells.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yiyun Song, Hui Yu, Qiaoling Sun, Fei Pei, Qing Xia, Zhaoli Gao, Xianhua Li
Summary: Grape seed proanthocyanidin extract (GSPE) can maintain the balance between mitochondrial biogenesis and dynamics by negatively regulating p66Shc expression, and it has a renal protective effect in diabetic kidney disease (DKD).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Kangliang Sheng, Guanghui Zhang, Xiaowei Kong, Jingmin Wang, Wanmeng Mu, Yongzhong Wang
Summary: Encapsulating grape seed proanthocyanidin extract (GSPE) using materials such as sodium alginate (SA) can improve stability and release efficiency, effectively immobilizing GSPE in polymeric microcapsules for controlled release. Research has shown that microcapsules made with SA-methyl cellulose (MC) and SA-hydroxypropyl methylcellulose (HPMC) exhibit higher thermal stability, making them suitable for maintaining GSPE content and release efficiency.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Elia Navarro-Masip, Marina Colom-Pellicer, Francesca Manocchio, Anna Arola-Arnal, Francisca Isabel Bravo, Begona Muguerza, Gerard Aragones
Summary: Seasonal rhythms and photoperiod can influence metabolism and adipose tissue functionality. Supplementation with grape-seed proanthocyanidins extract (GSPE) has shown potential in preventing obesity-related alterations. In this study, GSPE supplementation was found to prevent excessive body weight gain and restore serum cholesterol and non-esterified fatty acids (NEFAs) concentrations depending on the photoperiod. GSPE also helped combat obesity-induced adipocyte hypertrophy and upregulated adiponectin mRNA levels. Overall, GSPE administration reduced the impact of obesity on adipose tissue depending on the photoperiod and type of adipose depots.
Article
Biochemistry & Molecular Biology
Xixi Zhao, Ruofei Tian, Jingyi Zhou, Yanlin Liu
Summary: Food-borne fungi pose significant hazards to food preservation and human health, calling for packaging films with antimicrobial and antioxidant activities. In this study, silver nanoparticles were synthesized from grape seed extracts and coated with chitosan. The results showed that grapes treated with chitosan-coated silver nanoparticles exhibited reduced decay percentage and weight loss, maintained high titratable acidity, and inhibited mold growth during storage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yan Qi, Shilei Chen, Yukai Lu, Zihao Zhang, Song Wang, Naicheng Chen, Mingqiang Shen, Fang Chen, Mo Chen, Yong Quan, Lijing Yang, Yang Xu, Yongping Su, Mengjia Hu, Junping Wang
Summary: The research demonstrates that grape seed proanthocyanidin extract can ameliorate IR-induced HSPC injury by upregulating the expression of Foxo1 and its target antioxidant genes, thereby reducing ROS production and DNA damage while increasing HSC reconstituting ability and survival in irradiated mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)