Article
Medicine, Research & Experimental
Georgiana Toma, Eliza Karapetian, Chiara Massa, Dagmar Quandt, Barbara Seliger
Summary: HDACi treatment increases intracellular protein acetylation level in CD8(+) T cells, but the protein expression profiles are similar between different age groups. CD8(+) T cells from old donors exhibit higher cytokine secretion and activation marker expression compared to those from young donors, which may have clinical relevance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Raja Chakraborty, Allison C. Ostriker, Yi Xie, Jui M. Dave, Ana Gamez-Mendez, Payel Chatterjee, Yaw Abu, Jake Valentine, Kimberly Lezon-Geyda, Daniel M. Greif, Vincent P. Schulz, Patrick G. Gallagher, William C. Sessa, John Hwa, Kathleen A. Martin
Summary: This study reveals that p300 and CBP play distinct and opposing roles in VSMC phenotypic switching and co-regulate chromatin modifications through different functional interactions with TET2 or HDACs. Targeting specific histone acetyl-transferases may hold therapeutic promise for cardiovascular diseases.
Article
Cell Biology
Pablo Aurelio Gomez-Garcia, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali
Summary: The study reveals that differences in nucleosome "clutch" formation in embryonic stem cells and neural progenitor cells are associated with the structure of the Pou5f1 gene and the dynamics of core histone protein H2B. The stability and mobility of H2B vary between cell types, with implications for gene regulation and cell identity.
Article
Pharmacology & Pharmacy
Saadia Khilji, Yuan Li, Jihong Chen, Qiao Li
Summary: Bexarotene, an agonist of retinoid X receptor, plays a crucial role in promoting myoblast differentiation. Integration of RNA-seq and ChIP-seq data helps decipher the molecular regulation of rexinoid signaling in myogenic differentiation. These datasets provide strategies and a framework for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell & Tissue Engineering
Haiyun Luo, Yachuan Zhou, Wenjing Liu
Summary: This review discusses the impact of metabolic fluctuations on epigenetic modifications in the oral and maxillofacial regions, summarizes the interaction between metabolite substrates and canonical epigenetic events in dental mesenchymal stem cells, and highlights the important role of the coordination between metabolic pathways and epigenetic events in cellular processes.
STEM CELLS INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Lee-Ann Niekerk, Mogamat Fahiem Carelse, Olalekan Olanrewaju Bakare, Vuyo Mavumengwana, Marshall Keyster, Arun Gokul
Summary: The review discusses the negative impact of heavy metals such as cadmium on staple crop production and the role of epigenetic mechanisms in enhancing cadmium tolerance. Understanding and utilizing these genetic mechanisms can provide a crucial framework for improving plant cadmium tolerance in future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Qiao Li, Yan Z. Mach, Munerah Hamed, Saadia Khilji, Jihong Chen
Summary: Histone acetylation and deacetylation play important roles in gene expression during cellular differentiation. The acetyltransferase p300 is essential for muscle gene expression, while histone deacetylases (HDACs) control gene repression in stem cell fate transition. The expression of Hdac11 is enhanced by nuclear receptor signaling, and it may be essential for differential gene expression during myoblast differentiation.
Review
Biochemistry & Molecular Biology
K. Gomathi, N. Akshaya, N. Srinaath, M. Rohini, N. Selvamurugan
Summary: Bone remodeling is a complex event crucial for maintaining bone homeostasis, with histone acetylation playing a key role in the process. Studies have shown that histone acetyltransferases are major promoters of acetylation, and noncoding RNAs are also involved in regulating acetylation. Understanding these regulatory mechanisms may offer new insights for epigenetic therapies of bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Ming Zhao, Sujie Jia, Xiaofei Gao, Hong Qiu, Ruifang Wu, Haijing Wu, Qianjin Lu
Summary: This study revealed 802 upregulated and 598 downregulated proteins in iTfh cells compared to naive CD4(+) T cells. Intensive bioinformatics analysis provided insights into the biological processes, cellular compartments, molecular functions, KEGG pathways, and protein-protein interactions of these differentially expressed proteins. The acetylome data showed differential levels of lysine acetylation in iTfh cells, with a specific focus on core histones, suggesting a role for protein acetylation and epigenetic mechanisms in regulating Tfh cell differentiation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Maoxiao Feng, Xiaoyan Liu, Xiaodong Hao, Yidan Ren, Guoying Dong, Jie Tian, Yuli Wang, Lutao Du, Yunshan Wang, Chuanxin Wang
Summary: CD8(+) tissue-resident memory T (Trm) cells and tumor-infiltrating lymphocytes (TIL) play crucial roles in tumor immunity and immune surveillance. The transcription factor SCML4 is found to be essential for the development and polyfunctionality of Trm cells, and its expression is associated with a better prognosis in cancer patients. SCML4 recruits the HBO1-BRPF2-ING4 complex to reprogram T cell-specific gene expression, enhancing the survival and effector functions of Trm cells and TILs. Fatty acid metabolism induces SCML4 expression through the mTOR-IRF4-PRDM1 signaling pathway, promoting tissue-resident and multifunctional gene expression in Trm cells and TILs. These findings provide mechanistic insights into the functional regulation of tumor-localized Trm cells and TILs and identify an important target for tumor immunotherapy.
Article
Genetics & Heredity
Phoebe Y. T. Lu, Alyssa C. Kirlin, Maria J. Aristizabal, Hilary T. Brewis, Nancy Levesque, Dheva T. Setiaputra, Nikita Avvakumov, Joris J. Benschop, Marian Groot Koerkamp, Frank C. P. Holstege, Nevan J. Krogan, Calvin K. Yip, Jacques Cote, Michael S. Kobor
Summary: The NuA4 lysine acetyltransferase complex can function as picNuA4 independently, and its regulation involves physical interactions between the C-terminus of Epl1 and the HSA domain of Eaf1. Disruption of the Epl1-Eaf1 interaction can release picNuA4 from NuA4, indicating a complex relationship between the two in regulating picNuA4 amount and activity.
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Article
Multidisciplinary Sciences
Evan W. Weber, Kevin R. Parker, Elena Sotillo, Rachel C. Lynn, Hima Anbunathan, John Lattin, Zinaida Good, Julia A. Belk, Bence Daniel, Dorota Klysz, Meena Malipatlolla, Peng Xu, Malek Bashti, Sabine Heitzeneder, Louai Labanieh, Panayiotis Vandris, Robbie G. Majzner, Yanyan Qi, Katalin Sandor, Ling-Chun Chen, Snehit Prabhu, Andrew J. Gentles, Thomas J. Wandless, Ansuman T. Satpathy, Howard Y. Chang, Crystal L. Mackall
Summary: This study showed that transient cessation of chimeric antigen receptor (CAR) signaling can enhance the efficacy of CAR-T cells, reactivating their anti-tumor functions, and challenging the notion that exhaustion is an epigenetically fixed state.
Article
Biochemistry & Molecular Biology
Dania Riegel, Elena Romero-Fernandez, Malte Simon, Akinbami Raphael Adenugba, Katrin Singer, Roman Mayr, Florian Weber, Mark Kleemann, Charles D. Imbusch, Marina Kreutz, Benedikt Brors, Ines Ugele, Jens M. Werner, Peter J. Siska, Christian Schmidl
Summary: By integrating single-cell chromatin accessibility and RNA-seq data, we identified the heterogeneous functional and dysfunctional states of CD8+ tumor-infiltrating lymphocytes and revealed common chromatin remodeling and key regulatory factors involved in this process.