Article
Biochemistry & Molecular Biology
Sung-Sik Yoon, Eun-Yi Moon
Summary: RA-FLSs, activated by TNF-alpha, may promote joint damage through the up-regulation of hVCAM1 and hBAFF, which could influence the interaction between B cells and synovial cells, contributing to the pathogenesis of rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yixiong Chen, Junlong Dang, Xiaorong Lin, Manli Wang, Yan Liu, Jingrong Chen, Ye Chen, Xiqing Luo, Zuoyu Hu, Weizhen Weng, Xiaoyi Shi, Xuan Bi, Yan Lu, Yunfeng Pan
Summary: This study found that EVs derived from RA FLSs can promote angiogenesis in ECs, primarily through the miR-1972 targeting of the p53/mTOR signaling pathway. This research provides a promising strategy for the treatment of RA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zihan Wang, Jinping Wang, Tianyi Lan, Liubo Zhang, Zeran Yan, Nan Zhang, Yuan Xu, Qingwen Tao
Summary: Fibroblast-activated protein-a (FAP) is overexpressed by activated fibroblasts during fibrosis or inflammation. It plays important roles in regulating the cellular responses in the synovial region of rheumatoid arthritis (RA), and its overexpression is regulated by the initial inflammatory microenvironment and epigenetic signaling. Targeted therapies for FAP are currently being developed. This review discusses the features of FAP in FLSs and its role in RA pathophysiology, as well as advances in targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiao Li, Xinyuan Sun, Zhongyi Yan, Zhenxiang Zhao, Zhaojun Pang, Han Yang, Xiaoxin Ji, Yi Lei, Zixiang Zhu, Xiangqian Guo, Xin Mu
Summary: A study has found that an antibiotic called gramicidin A can enhance MDA5-mediated interferon signaling by increasing the oligomerization of MDA5 and dsRNA.
Article
Multidisciplinary Sciences
Po-Chuan Shen, Po-Chun Chang, Jeng-Long Hsieh
Summary: The study demonstrated the correlation between nuclear expression of Snail in CIA FLSs from rats with the levels of extracellular TNF-alpha and acetylation status. Intervention targeting the TNF-alpha-histone deacetylase-Snail signaling axis or the Wnt signaling pathway in FLSs may offer new therapeutic opportunities for treating RA. The inhibitory effects on cell proliferation and viability of CIA FLSs were observed with TSA treatment and specific RNA interference targeting Snail, while LiCl treatment increased Snail and Cadherin-11 expression in CIA FLSs.
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jakub Chwastek, Marta Kedziora, Malgorzata Borczyk, Michal Korostynski, Katarzyna Starowicz
Summary: Osteoarthritis is a common joint pathology in developed countries and a major cause of disability. This study found that synoviocytes, which build the joint membrane, contribute to the development of osteoarthritis. The synoviocytes of osteoarthritis patients show an enhanced response to inflammatory factors and secrete proteins that may promote disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yujing Xue, Sheng Zhou, Zhicheng Yang, Pengyan Hao, Liqun Wang, Weiding Cui, Weixi Liu, Ruiping Liu
Summary: This study investigated the anti-inflammatory effects and mechanisms of A. sinensis polysaccharide (ASP) on rheumatoid arthritis (RA). The results showed that ASP dose-dependently inhibited the proliferation, migration, and invasion of inflammatory cells, promoted apoptosis, and arrested the cell cycle. In an animal model of RA, ASP reduced symptoms and decreased the expression of pro-inflammatory cytokines. ASP exerted its effects by inhibiting the JAK2/STAT3 and MAPK signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Adham Abuelola Mohamed, Sofia Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G. G. Brooks, Martin Schlee
Summary: NK cell activation in response to Influenza A virus infection depends on the cytosolic RNA receptor RIG-I, and activation of RIG-I enhances both the antiviral defense and cytotoxic effector function of NK cells against target cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Chunfeng Ren, Jie Chen, Qincheng Che, Qian Jia, Hongqin Lu, Xiaoyan Qi, Xiaojie Zhang, Qiang Shu
Summary: IL-37 alleviates TNF-a-induced pyroptosis of RA FLSs by inhibiting NF-?B/GSDMD signaling, and it also exhibits anti-inflammatory effects both in vitro and in vivo. This study provides new potential for IL-37 as a therapy for RA.
Article
Pharmacology & Pharmacy
Vladislav Tsaltskan, Gary S. Firestein
Summary: Fibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA), but in RA, fibroblasts become a key driver of synovial inflammation and joint damage. There has been recent interest in targeting FLS for RA treatment and the effects of FLS-targeted drugs are discussed.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Review
Oncology
Yangfu Jiang, Hongying Zhang, Jiao Wang, Jinzhu Chen, Zeyu Guo, Yongliang Liu, Hui Hua
Summary: RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune responses. Manipulation of RLRs signaling represents an opportunity for clinically relevant cancer therapy, as therapeutic targeting RLRs can not only provoke anti-infection effects but also induce anticancer immunity or sensitize immune-cold tumors to immune checkpoint blockade.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Guangxue Gu, Yongfeng Huo, Gang Xu, Leiming Li, Jian Yu, Luxin Sheng, Zhaoyang Yin
Summary: In patients with AS, decreased miR-204 and elevated GSDMD levels were found in synovial tissue. miR-204 directly targeted GSDMD and inhibited its protein expression, leading to a suppression of pyroptosis in FLSs. Up-regulating miR-204 may offer a potential therapeutic target for AS by targeting GSDMD to reduce pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
