Article
Biology
Zhiwen Wu, Toshiaki Yoshikawa, Satoshi Inoue, Yusuke Ito, Hitomi Kasuya, Takahiro Nakashima, Haosong Zhang, Saki Kotaka, Waki Hosoda, Shiro Suzuki, Yuki Kagoya
Summary: T cell exhaustion is a major obstacle to effective cancer immunotherapy. CD83 is identified as a marker to distinguish precursor exhausted T cells from other tumor-infiltrating T lymphocyte subsets. CD83 is predominantly expressed in CCR7(+)PD1(+) T cells and is associated with superior antigen-induced proliferation and IL-2 production.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Wei Lin, Shuping Zhou, Meng Feng, Yong Yu, Qinghong Su, Xiaofan Li
Summary: The study demonstrated that sCD83 inhibits T cell activation by disrupting DC-T contact and immunological synapse formation, mainly through disrupting F-actin rearrangements in dendritic cells. This novel signaling pathway may be a potential target for developing new immunosuppressive therapies for autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Li-Hua Mo, Xiang-Qian Luo, Gui Yang, Jiang-Qi Liu, Li-Teng Yang, Zhi-Qiang Liu, Shuai Wang, Da-Bo Liu, Zhi-Gang Liu, Ping-Chang Yang
Summary: This study demonstrates the crucial role of CD83 in Treg differentiation in the airway mucosa and the ability of CD83/OVA-carrying exosomes to inhibit airway allergy. These findings provide a new potential approach for the treatment of airway allergic disorders.
Article
Cell Biology
Shuwa Xu, Alina P. Sergeeva, Phinikoula S. Katsamba, Seetha Mannepalli, Fabiana Bahna, Jude Bimela, S. Lawrence Zipursky, Lawrence Shapiro, Barry Honig, Kai Zinn
Summary: The study reveals that CAM binding affinities and expression levels play crucial roles in neuronal development, influencing synaptic targeting and survival of neurons, with surface avidity being the key parameter controlling circuit assembly.
Review
Biochemistry & Molecular Biology
Bushra Riaz, S. M. Shamsul Islam, Hye Myung Ryu, Seonghyang Sohn
Summary: Activating the immune system is important for maintaining homeostasis and defending against infections, but abnormalities in the immune response can lead to harmful immunopathological responses and severe inflammation. Dendritic cells play a role in influencing immune responses through the differentiation of T cells. CD83, expressed on mature dendritic cells, activated B cells, and T cells, has been studied extensively and has been suggested to have functions in co-stimulation and resolving inflammatory reactions. However, its roles in autoimmune diseases and pathogen immune evasion are not fully understood. This article outlines current findings and proposed functions of CD83 in inflammatory disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
S. M. Shamsul Islam, Hye-Myung Ryu, Seonghyang Sohn
Summary: This study aimed to investigate the anti-inflammatory effect of Tetragenococcus halophilus (T. halophilus) as a probiotic on intestinal inflammation in mice. The results showed that T. halophilus could alleviate DSS-induced colitis in mice by reducing weight loss, suppressing colonic shortening, and altering immune regulation and gut microbiome compositions.
Article
Immunology
Yong Yu, Qiao-Ruo Jin, Yang Mi, Jiang-Qi Liu, Zhi-Qiang Liu, Shuai Wang, Zhi-Gang Liu, Ping-Chang Yang, Peng-Yuan Zheng
Summary: This study investigated the role of intestinal epithelial cell (IEC)-derived CD83 in the generation of antigen-specific regulatory T cells (Tregs) in the intestine. The results showed that CD83 promotes the expression of TIEG1 in CD4+ T cells, and the CD83/TLR4/MD-2/TIEG1 pathway plays a critical role in Treg generation. Concomitant administration of CD83 and specific antigens efficiently inhibited food allergy in a murine model by inducing Tregs in the intestine, suggesting the translational potential of CD83 in the treatment of food allergy.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Immunology
Byron Morales-Lange, Felipe Ramirez-Cepeda, Paulina Schmitt, Fanny Guzman, Leidy Lagos, Margareth Overland, Valentina Wong-Benito, Monica Imarai, Derie Fuentes, Sebastian Boltana, Javier Alcaino, Carlos Soto, Luis Mercado
Summary: This study investigated the effect of IFN gamma on the expression of cell-surface markers on splenocytes of Atlantic salmon. The results showed that IFN gamma could stimulate the gene expression and protein availability of cell-surface markers, enhancing the function of immune cells. In vivo experiments demonstrated that during a natural outbreak of Piscirickettsia salmonis, the expression of IFN gamma in Atlantic salmon increased simultaneously with the up-regulation of cell-surface markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuri Kim, Thomas Myeongseok Koo, Ramar Thangam, Myeong Soo Kim, Woo Young Jang, Nayeon Kang, Sunhong Min, Seong Yeol Kim, Letao Yang, Hyunsik Hong, Hee Joon Jung, Eui Kwan Koh, Kapil D. Patel, Sungkyu Lee, Hong En Fu, Yoo Sang Jeon, Bum Chul Park, Soo Young Kim, Steve Park, Junmin Lee, Luo Gu, Dong-Hyun Kim, Tae-Hyung Kim, Ki-Bum Lee, Woong Kyo Jeong, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang
Summary: The study demonstrates the modulation of integrin recognition and macrophage adhesion by tuning the submolecular ligand size and spacing at the nanoscale level.
ADVANCED MATERIALS
(2022)
Article
Virology
Ning Ma, Xingjie Li, Hongyu Jiang, Yulong Dai, Guofeng Xu, Zongde Zhang
Summary: Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. The study has shown that influenza virus neuraminidase unmasked CD83 protein in the lung and contributed to high cytokine levels. Anti-CD83 treatment could alleviate lung injury caused by influenza virus.
JOURNAL OF VIROLOGY
(2021)
Article
Cell Biology
Emilie Biele, Sebastian J. Schober, Carolin Prexler, Melanie Thiede, Kristina von Heyking, Hendrik Gassmann, Jennifer Eck, Busheng Xue, Stefan Burdach, Uwe Thiel
Summary: The study found that by using different cytokines, the immunogenic cell surface marker expression on EwS cells can be enhanced, leading to significantly improved recognition and killing of tumor cells by CHM1(319)-specific TCR-transgenic T cells.
Article
Oncology
Shernan G. Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A. Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L. MacMillan, Daniel J. Weisdorf, Martin Felices, Jeffrey S. Miller, Bruce R. Blazar, Marco L. Davila, Brian C. Betts
Summary: This study investigates the association between CD83 expression on GVHD effector cells and clinical outcomes after allogeneic hematopoietic cell transplantation. The results show that CD83 overexpression correlates with reduced survival and increased TRM. CD83 CAR T can eliminate autoreactive CD83+ B cells without causing B-cell aplasia. CD83 may serve as a diagnostic marker of GVHD and a therapeutic target for both GVHD and AML relapse after alloHCT.
CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Gunhyu Bae, Myeong Soo Kim, Ramar Thangam, Thomas Myeongseok Koo, Woo Young Jang, Jinho Yoon, Seong-Beom Han, Letao Yang, Seong Yeol Kim, Nayeon Kang, Sunhong Min, Hyunsik Hong, Hong En Fu, Min Jun Ko, Dong-Hwee Kim, Woong Kyo Jeong, Dong-Hyun Kim, Tae-Hyung Kim, Jeong-Woo Choi, Ki-Bum Lee, Ramasamy Paulmurugan, Yangzhi Zhu, Han-Jun Kim, Junmin Lee, Jong Seung Kim, Ali Khademhosseini, Young Keun Kim, Heemin Kang
Summary: The study focuses on tuning the diameter and interdistance of RGD-bearing AuNPs on Fe3O4 nanotemplates to regulate stem cell differentiation and adhesion functions.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Physics, Multidisciplinary
Long Li, Jinglei Hu, Huaping Wu, Fan Song
Summary: Cell adhesion on a supported lipid bilayer functionalized with ligand proteins is widely used to study trans receptor-ligand interaction, with attractive cis-interaction between ligands on the SLB amplifying both affinity and cooperativity of the binding, suggesting careful consideration of ligand-ligand cis-interaction in experiments.
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
(2021)
Article
Immunology
S. M. Shamsul Islam, Hye-Myung Ryu, Hasan M. Sayeed, Hae-Ok Byun, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh, Seonghyang Sohn
Summary: The study aimed to investigate the effect of Eubacterium rectale administration on DC activation and systemic inflammation in HSV-1-induced Behcet's disease. Results showed that E. rectale reduced the frequency of CD83+ cells and increased NK1.1+ cells in BD mice, improving symptoms. Co-administration of colchicine and E. rectale also decreased the frequency of CD83+ cells, suggesting E. rectale as a potential therapeutic adjuvant for BD management.
FRONTIERS IN IMMUNOLOGY
(2021)